Osanetant

Osanetant
Osanetant
Systematic (IUPAC) name
N-(1-{3-[(3R)-1-benzoyl-3-(3,4-dichlorophenyl)piperidin-3-yl]propyl}-4-phenylpiperidin-4-yl]-N-methylacetamide
Clinical data
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 160492-56-8 YesY
ATC code None
PubChem CID 219077
UNII K7G81N94DT YesY
ChEMBL CHEMBL346178 N
Chemical data
Formula C35H41Cl2N3O2 
Mol. mass 606.625 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Osanetant (SR-142,801) is a neurokinin 3 receptor antagonist developed by Sanofi-Synthélabo, which is being researched for the treatment of schizophrenia.[1] It was the first non-peptide NK3 antagonist developed in the mid-1990s,[2] and has still not made it to market, although clinical trials are continuing.[3] Another potential application for osanetant is in the treatment of drug addiction, as it has been found to block the effects of cocaine in animal models.[4][5]

References

  1. ^ Kamali, F (July 2001). "Osanetant Sanofi-Synthélabo". Current opinion in investigational drugs (London, England : 2000) 2 (7): 950–6. PMID 11757797. 
  2. ^ Emonds-Alt, X; Bichon, D; Ducoux, JP; Heaulme, M; Miloux, B; Poncelet, M; Proietto, V; Van Broeck, D et al. (1995). "SR 142801, the first potent non-peptide antagonist of the tachykinin NK3 receptor". Life sciences 56 (1): PL27–32. doi:10.1016/0024-3205(94)00413-M. PMID 7830490. 
  3. ^ Quartara L, Altamura M (August 2006). "Tachykinin receptors antagonists: from research to clinic". Current Drug Targets 7 (8): 975–92. doi:10.2174/138945006778019381. PMID 16918326. http://www.benthamdirect.org/pages/content.php?CDT/2006/00000007/00000008/0007J.SGM. Retrieved 2011-04-14. 
  4. ^ Desouzasilva, M; Mellojr, E; Muller, C; Jocham, G; Maior, R; Huston, J; Tomaz, C; Barros, M (May 2006). "The tachykinin NK3 receptor antagonist SR142801 blocks the behavioral effects of cocaine in marmoset monkeys". European Journal of Pharmacology 536 (3): 269–78. doi:10.1016/j.ejphar.2006.03.010. PMID 16603151. 
  5. ^ Jocham, Gerhard; Lezoch, Katharina; Müller, Christian P.; Kart-Teke, Emriye; Huston, Joseph P.; De Souza Silva, M. AngéLica (September 2006). "Neurokinin receptor antagonism attenuates cocaine's behavioural activating effects yet potentiates its dopamine-enhancing action in the nucleus accumbens core". European Journal of Neuroscience 24 (6): 1721–32. doi:10.1111/j.1460-9568.2006.05041.x. PMID 17004936. 


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