Melanocortin 3 receptor

Melanocortin 3 receptor
Identifiers
Symbols	MC3R; BMIQ9; MC3; MC3-R; OB20; OQTL
External IDs	OMIM: 155540 MGI: 96929 HomoloGene: 7412 GeneCards: MC3R Gene
Gene Ontology Molecular function • receptor activity • G-protein coupled receptor activity • melanocortin receptor activity • melanocyte-stimulating hormone receptor activity • protein binding • peptide hormone binding • neuropeptide binding Cellular component • plasma membrane • plasma membrane • integral to plasma membrane Biological process • G-protein signaling, coupled to cyclic nucleotide second messenger • G-protein signaling, coupled to cAMP nucleotide second messenger • activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger • positive regulation of cAMP biosynthetic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4159	17201
Ensembl	ENSG00000124089	ENSMUSG00000038537
UniProt	P41968	Q3ZAT4
RefSeq (mRNA)	NM_019888	NM_008561.3
RefSeq (protein)	NP_063941	NP_032587.1
Location (UCSC)	Chr 20: 54.82 – 54.82 Mb	Chr 2: 172.07 – 172.08 Mb
PubMed search	[1]	[2]

Melanocortin receptor 3 is a protein that in humans is encoded by the MC3R gene.^[1][2]

This gene encodes MC₃, a G-protein coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake suggesting a role for this gene product in the regulation of energy homeostasis.^[2]

See also

• Melanocortin receptor

References

1. ^ Gantz I, Konda Y, Tashiro T, Shimoto Y, Miwa H, Munzert G, Watson SJ, DelValle J, Yamada T (May 1993). "Molecular cloning of a novel melanocortin receptor". J Biol Chem 268 (11): 8246–50. PMID 8463333. 
2. ^ ^{a b} "Entrez Gene: MC3R melanocortin 3 receptor". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4159. 

External links

• "Melanocortin Receptors: MC₃". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2352. 

Further reading

• Magenis RE, Smith L, Nadeau JH, et al. (1994). "Mapping of the ACTH, MSH, and neural (MC3 and MC4) melanocortin receptors in the mouse and human". Mamm. Genome 5 (8): 503–8. doi:10.1007/BF00369320. PMID 7949735. 
• Konda Y, Gantz I, DelValle J, et al. (1994). "Interaction of dual intracellular signaling pathways activated by the melanocortin-3 receptor". J. Biol. Chem. 269 (18): 13162–6. PMID 8175743. 
• Gantz I, Tashiro T, Barcroft C, et al. (1994). "Localization of the genes encoding the melanocortin-2 (adrenocorticotropic hormone) and melanocortin-3 receptors to chromosomes 18p11.2 and 20q13.2-q13.3 by fluorescence in situ hybridization". Genomics 18 (1): 166–7. doi:10.1006/geno.1993.1448. PMID 8276410. 
• Yang YK, Ollmann MM, Wilson BD, et al. (1997). "Effects of recombinant agouti-signaling protein on melanocortin action". Mol. Endocrinol. 11 (3): 274–80. doi:10.1210/me.11.3.274. PMID 9058374. 
• Tota MR, Smith TS, Mao C, et al. (1999). "Molecular interaction of Agouti protein and Agouti-related protein with human melanocortin receptors". Biochemistry 38 (3): 897–904. doi:10.1021/bi9815602. PMID 9893984. 
• McNulty JC, Thompson DA, Bolin KA, et al. (2002). "High-resolution NMR structure of the chemically-synthesized melanocortin receptor binding domain AGRP(87-132) of the agouti-related protein". Biochemistry 40 (51): 15520–7. doi:10.1021/bi0117192. PMID 11747427. 
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052. 
• Lee YS, Poh LK, Loke KY (2002). "A novel melanocortin 3 receptor gene (MC3R) mutation associated with severe obesity". J. Clin. Endocrinol. Metab. 87 (3): 1423–6. doi:10.1210/jc.87.3.1423. PMID 11889220. 
• Qian S, Chen H, Weingarth D, et al. (2002). "Neither agouti-related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice". Mol. Cell. Biol. 22 (14): 5027–35. doi:10.1128/MCB.22.14.5027-5035.2002. PMC 139785. PMID 12077332. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139785. 
• Boucher N, Lanouette CM, Larose M, et al. (2003). "A +2138InsCAGACC polymorphism of the melanocortin receptor 3 gene is associated in human with fat level and partitioning in interaction with body corpulence". Mol. Med. 8 (3): 158–65. PMC 2039979. PMID 12142547. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2039979. 
• Wong J, Love DR, Kyle C, et al. (2002). "Melanocortin-3 receptor gene variants in a Maori kindred with obesity and early onset type 2 diabetes". Diabetes Res. Clin. Pract. 58 (1): 61–71. doi:10.1016/S0168-8227(02)00126-2. PMID 12161058. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Rached M, Buronfosse A, Begeot M, Penhoat A (2004). "Inactivation and intracellular retention of the human I183N mutated melanocortin 3 receptor associated with obesity". Biochim. Biophys. Acta 1689 (3): 229–34. doi:10.1016/j.bbadis.2004.03.009. PMID 15276649. 
• Tao YX, Segaloff DL (2004). "Functional characterization of melanocortin-3 receptor variants identify a loss-of-function mutation involving an amino acid critical for G protein-coupled receptor activation". J. Clin. Endocrinol. Metab. 89 (8): 3936–42. doi:10.1210/jc.2004-0367. PMID 15292330. 
• Lapinsh M, Veiksina S, Uhlén S, et al. (2005). "Proteochemometric mapping of the interaction of organic compounds with melanocortin receptor subtypes". Mol. Pharmacol. 67 (1): 50–9. doi:10.1124/mol.104.002857. PMID 15470082. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Mandrika I, Petrovska R, Wikberg J (2005). "Melanocortin receptors form constitutive homo- and heterodimers". Biochem. Biophys. Res. Commun. 326 (2): 349–54. doi:10.1016/j.bbrc.2004.11.036. PMID 15582585. 
• de Krom M, de Rijke CE, Hendriks J, et al. (2006). "Mutation analysis of the agouti related protein promoter region and the melanocortin-3 receptor in anorexia nervosa patients". Psychiatr. Genet. 15 (4): 237. doi:10.1097/00041444-200512000-00003. PMID 16314751. 
• Chen M, Aprahamian CJ, Celik A, et al. (2006). "Molecular characterization of human melanocortin-3 receptor ligand-receptor interaction". Biochemistry 45 (4): 1128–37. doi:10.1021/bi0521792. PMID 16430209. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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