G protein-coupled bile acid receptor

The G protein-coupled bile acid receptor is a G-protein coupled receptor which binds bile acids.cite journal | author = Kawamata Y, Fujii R, Hosoya M, Harada M, Yoshida H, Miwa M, Fukusumi S, Habata Y, Itoh T, Shintani Y, Hinuma S, Fujisawa Y, Fujino M | title = A G protein-coupled receptor responsive to bile acids | journal = J. Biol. Chem. | volume = 278 | issue = 11 | pages = 9435–40 | year = 2003 | pmid = 12524422 | doi = 10.1074/jbc.M209706200 | issn = ] One effect of this receptor is to activate deiodinases which convert the prohormone thyroxine (T₄) to the active hormone triiodothyronine (T₃). T₃ in turn activates the thyroid hormone receptor which increases metabolic rate.cite journal | author = Watanabe M, Houten SM, Mataki C, Christoffolete MA, Kim BW, Sato H, Messaddeq N, Harney JW, Ezaki O, Kodama T, Schoonjans K, Bianco AC, Auwerx J | title = Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation | journal = Nature | volume = 439 | issue = 7075 | pages = 484–9 | year = 2006 | pmid = 16400329 | doi = 10.1038/nature04330 | issn = ] cite journal | author = Baxter JD, Webb P | title = Metabolism: bile acids heat things up | journal = Nature | volume = 439 | issue = 7075 | pages = 402–3 | year = 2006 | pmid = 16437098 | doi = 10.1038/439402a | issn = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein.cite web | title = Entrez Gene: GPBAR1 G protein-coupled bile acid receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=151306| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Takeda S, Kadowaki S, Haga T, "et al." |title=Identification of G protein-coupled receptor genes from the human genome sequence. |journal=FEBS Lett. |volume=520 |issue= 1-3 |pages= 97–101 |year= 2002 |pmid= 12044878 |doi=
*cite journal | author=Maruyama T, Miyamoto Y, Nakamura T, "et al." |title=Identification of membrane-type receptor for bile acids (M-BAR). |journal=Biochem. Biophys. Res. Commun. |volume=298 |issue= 5 |pages= 714–9 |year= 2003 |pmid= 12419312 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kawamata Y, Fujii R, Hosoya M, "et al." |title=A G protein-coupled receptor responsive to bile acids. |journal=J. Biol. Chem. |volume=278 |issue= 11 |pages= 9435–40 |year= 2003 |pmid= 12524422 |doi= 10.1074/jbc.M209706200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Watanabe M, Houten SM, Mataki C, "et al." |title=Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. |journal=Nature |volume=439 |issue= 7075 |pages= 484–9 |year= 2006 |pmid= 16400329 |doi= 10.1038/nature04330
*cite journal | author=Thomas SM, Bhola NE, Zhang Q, "et al." |title=Cross-talk between G protein-coupled receptor and epidermal growth factor receptor signaling pathways contributes to growth and invasion of head and neck squamous cell carcinoma. |journal=Cancer Res. |volume=66 |issue= 24 |pages= 11831–9 |year= 2007 |pmid= 17178880 |doi= 10.1158/0008-5472.CAN-06-2876
*cite journal | author=Yasuda H, Hirata S, Inoue K, "et al." |title=Involvement of membrane-type bile acid receptor M-BAR/TGR5 in bile acid-induced activation of epidermal growth factor receptor and mitogen-activated protein kinases in gastric carcinoma cells. |journal=Biochem. Biophys. Res. Commun. |volume=354 |issue= 1 |pages= 154–9 |year= 2007 |pmid= 17214962 |doi= 10.1016/j.bbrc.2006.12.168
*cite journal | author=Keitel V, Reinehr R, Gatsios P, "et al." |title=The G-protein coupled bile salt receptor TGR5 is expressed in liver sinusoidal endothelial cells. |journal=Hepatology |volume=45 |issue= 3 |pages= 695–704 |year= 2007 |pmid= 17326144 |doi= 10.1002/hep.21458

External links

* [http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1332 IUPHAR GPCR Database - Bile acid receptor]
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