[cite journal | author = Gerard C, Gerard NP | title = C5A anaphylatoxin and its seven transmembrane-segment receptor | journal = Annu. Rev. Immunol. | volume = 12 | issue = | pages = 775–808 | year = 1994 | pmid = 8011297 | doi = 10.1146/annurev.iy.12.040194.004015 | issn = ] ]Cells
The C5a receptor is expressed on: [ Unless else specified in list, then ref is: [http://mpr.nci.nih.gov/prow/guide/666919736_g.htm PROW and IWHLDA: CD88] ]
*Granulocytes
*Monocytes
*Dendritic cells
*Hepatoma-derived cell line HepG2
*Astrocytes
*Microglia
ee also
*Complement component 5a for binding mechanism
References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Sengeløv H |title=Complement receptors in neutrophils. |journal=Crit. Rev. Immunol. |volume=15 |issue= 2 |pages= 107–31 |year= 1996 |pmid= 8573284 |doi=
*cite journal | author=Beil WJ, Schulz M, Wefelmeyer U |title=Mast cell granule composition and tissue location--a close correlation. |journal=Histol. Histopathol. |volume=15 |issue= 3 |pages= 937–46 |year= 2001 |pmid= 10963136 |doi=
*cite journal | author=Yamamoto T |title=Roles of the ribosomal protein S19 dimer and the C5a receptor in pathophysiological functions of phagocytic leukocytes. |journal=Pathol. Int. |volume=57 |issue= 1 |pages= 1–11 |year= 2007 |pmid= 17199736 |doi= 10.1111/j.1440-1827.2007.02049.x
*cite journal | author=Bao L, Gerard NP, Eddy RL, "et al." |title=Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19. |journal=Genomics |volume=13 |issue= 2 |pages= 437–40 |year= 1992 |pmid= 1612600 |doi=
*cite journal | author=Gerard NP, Gerard C |title=The chemotactic receptor for human C5a anaphylatoxin. |journal=Nature |volume=349 |issue= 6310 |pages= 614–7 |year= 1991 |pmid= 1847994 |doi= 10.1038/349614a0
*cite journal | author=Boulay F, Mery L, Tardif M, "et al." |title=Expression cloning of a receptor for C5a anaphylatoxin on differentiated HL-60 cells. |journal=Biochemistry |volume=30 |issue= 12 |pages= 2993–9 |year= 1991 |pmid= 2007135 |doi=
*cite journal | author=Wahl SM, Allen JB, Gartner S, "et al." |title=HIV-1 and its envelope glycoprotein down-regulate chemotactic ligand receptors and chemotactic function of peripheral blood monocytes. |journal=J. Immunol. |volume=142 |issue= 10 |pages= 3553–9 |year= 1989 |pmid= 2541200 |doi=
*cite journal | author=Foreman KE, Vaporciyan AA, Bonish BK, "et al." |title=C5a-induced expression of P-selectin in endothelial cells. |journal=J. Clin. Invest. |volume=94 |issue= 3 |pages= 1147–55 |year= 1994 |pmid= 7521884 |doi=
*cite journal | author=Giannini E, Brouchon L, Boulay F |title=Identification of the major phosphorylation sites in human C5a anaphylatoxin receptor in vivo. |journal=J. Biol. Chem. |volume=270 |issue= 32 |pages= 19166–72 |year= 1995 |pmid= 7642584 |doi=
*cite journal | author=Buhl AM, Osawa S, Johnson GL |title=Mitogen-activated protein kinase activation requires two signal inputs from the human anaphylatoxin C5a receptor. |journal=J. Biol. Chem. |volume=270 |issue= 34 |pages= 19828–32 |year= 1995 |pmid= 7649993 |doi=
*cite journal | author=Wennogle LP, Conder L, Winter C, "et al." |title=Stabilization of C5a receptor--G-protein interactions through ligand binding. |journal=J. Cell. Biochem. |volume=55 |issue= 3 |pages= 380–8 |year= 1994 |pmid= 7962171 |doi= 10.1002/jcb.240550316
*cite journal | author=Gerard NP, Bao L, Xiao-Ping H, "et al." |title=Human chemotaxis receptor genes cluster at 19q13.3-13.4. Characterization of the human C5a receptor gene. |journal=Biochemistry |volume=32 |issue= 5 |pages= 1243–50 |year= 1993 |pmid= 8383526 |doi=
*cite journal | author=Ames RS, Li Y, Sarau HM, "et al." |title=Molecular cloning and characterization of the human anaphylatoxin C3a receptor. |journal=J. Biol. Chem. |volume=271 |issue= 34 |pages= 20231–4 |year= 1996 |pmid= 8702752 |doi=
*cite journal | author=Werfel T, Zwirner J, Oppermann M, "et al." |title=CD88 antibodies specifically bind to C5aR on dermal CD117+ and CD14+ cells and react with a desmosomal antigen in human skin. |journal=J. Immunol. |volume=157 |issue= 4 |pages= 1729–35 |year= 1996 |pmid= 8759762 |doi=
*cite journal | author=Höpken UE, Lu B, Gerard NP, Gerard C |title=The C5a chemoattractant receptor mediates mucosal defence to infection. |journal=Nature |volume=383 |issue= 6595 |pages= 86–9 |year= 1996 |pmid= 8779720 |doi= 10.1038/383086a0
*cite journal | author=Chen Z, Zhang X, Gonnella NC, "et al." |title=Residues 21-30 within the extracellular N-terminal region of the C5a receptor represent a binding domain for the C5a anaphylatoxin. |journal=J. Biol. Chem. |volume=273 |issue= 17 |pages= 10411–9 |year= 1998 |pmid= 9553099 |doi=
*cite journal | author=Floreani AA, Heires AJ, Welniak LA, "et al." |title=Expression of receptors for C5a anaphylatoxin (CD88) on human bronchial epithelial cells: enhancement of C5a-mediated release of IL-8 upon exposure to cigarette smoke. |journal=J. Immunol. |volume=160 |issue= 10 |pages= 5073–81 |year= 1998 |pmid= 9590258 |doi=
*cite journal | author=Ottonello L, Corcione A, Tortolina G, "et al." |title=rC5a directs the in vitro migration of human memory and naive tonsillar B lymphocytes: implications for B cell trafficking in secondary lymphoid tissues. |journal=J. Immunol. |volume=162 |issue= 11 |pages= 6510–7 |year= 1999 |pmid= 10352266 |doi=
*cite journal | author=Kohleisen B, Shumay E, Sutter G, "et al." |title=Stable expression of HIV-1 Nef induces changes in growth properties and activation state of human astrocytes. |journal=AIDS |volume=13 |issue= 17 |pages= 2331–41 |year= 2000 |pmid= 10597774 |doi=
*cite journal | author= Monk PN, Scola A-M, Madala P, Fairlie DP| title=Function, structure and therapeutic potential of complement C5a receptors | journal= British Journal of Pharmacology | year= 2007| volume= 152| pages=429–48|pmid= 17603557|doi=
External links
* [http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2972 IUPHAR GPCR Database - C5a receptor]
*
PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = no
update_citations = yes
