C3a receptor

The C3a receptor also known as complement component 3a receptor 1 (C3AR1) is a G protein-coupled receptor protein involved in the complement system.cite journal | author = Roglic A, Prossnitz ER, Cavanagh SL, Pan Z, Zou A, Ye RD | title = cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure | journal = Biochim. Biophys. Acta | volume = 1305 | issue = 1-2 | pages = 39–43 | year = 1996 | pmid = 8605247 | doi = | issn = ] cite journal | author = Ali H, Panettieri RA | title = Anaphylatoxin C3a receptors in asthma | journal = Respir. Res. | volume = 6 | issue = | pages = 19 | year = 2005 | pmid = 15723703 | doi = 10.1186/1465-9921-6-19 | issn = ]

Although its official name implies it only binds C3a, it also binds C4a.

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Sim RB, Laich A |title=Serine proteases of the complement system. |journal=Biochem. Soc. Trans. |volume=28 |issue= 5 |pages= 545–50 |year= 2001 |pmid= 11044372 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Roglic A, Prossnitz ER, Cavanagh SL, "et al." |title=cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure. |journal=Biochim. Biophys. Acta |volume=1305 |issue= 1-2 |pages= 39–43 |year= 1996 |pmid= 8605247 |doi=
*cite journal | author=Ames RS, Li Y, Sarau HM, "et al." |title=Molecular cloning and characterization of the human anaphylatoxin C3a receptor. |journal=J. Biol. Chem. |volume=271 |issue= 34 |pages= 20231–4 |year= 1996 |pmid= 8702752 |doi=
*cite journal | author=Crass T, Raffetseder U, Martin U, "et al." |title=Expression cloning of the human C3a anaphylatoxin receptor (C3aR) from differentiated U-937 cells. |journal=Eur. J. Immunol. |volume=26 |issue= 8 |pages= 1944–50 |year= 1996 |pmid= 8765043 |doi=
*cite journal | author=Ames RS, Nuthulaganti P, Kumar C |title=In Xenopus oocytes the human C3a and C5a receptors elicit a promiscuous response to the anaphylatoxins. |journal=FEBS Lett. |volume=395 |issue= 2-3 |pages= 157–9 |year= 1996 |pmid= 8898085 |doi=
*cite journal | author=Martin U, Bock D, Arseniev L, "et al." |title=The human C3a receptor is expressed on neutrophils and monocytes, but not on B or T lymphocytes. |journal=J. Exp. Med. |volume=186 |issue= 2 |pages= 199–207 |year= 1997 |pmid= 9221749 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Hollmann TJ, Haviland DL, Kildsgaard J, "et al." |title=Cloning, expression, sequence determination, and chromosome localization of the mouse complement C3a anaphylatoxin receptor gene. |journal=Mol. Immunol. |volume=35 |issue= 3 |pages= 137–48 |year= 1998 |pmid= 9694514 |doi=
*cite journal | author=Lienenklaus S, Ames RS, Tornetta MA, "et al." |title=Human anaphylatoxin C4a is a potent agonist of the guinea pig but not the human C3a receptor. |journal=J. Immunol. |volume=161 |issue= 5 |pages= 2089–93 |year= 1998 |pmid= 9725198 |doi=
*cite journal | author=Davoust N, Jones J, Stahel PF, "et al." |title=Receptor for the C3a anaphylatoxin is expressed by neurons and glial cells. |journal=Glia |volume=26 |issue= 3 |pages= 201–11 |year= 1999 |pmid= 10340761 |doi=
*cite journal | author=Settmacher B, Bock D, Saad H, "et al." |title=Modulation of C3a activity: internalization of the human C3a receptor and its inhibition by C5a. |journal=J. Immunol. |volume=162 |issue= 12 |pages= 7409–16 |year= 1999 |pmid= 10358194 |doi=
*cite journal | author=Feild JA, Foley JJ, Testa TT, "et al." |title=Cloning and characterization of a rabbit ortholog of human Galpha16 and mouse G(alpha)15. |journal=FEBS Lett. |volume=460 |issue= 1 |pages= 53–6 |year= 1999 |pmid= 10571060 |doi=
*cite journal | author=Petering H, Köhl J, Weyergraf A, "et al." |title=Characterization of synthetic C3a analog peptides on human eosinophils in comparison to the native complement component C3a. |journal=J. Immunol. |volume=164 |issue= 7 |pages= 3783–9 |year= 2000 |pmid= 10725738 |doi=
*cite journal | author=Drouin SM, Kildsgaard J, Haviland J, "et al." |title=Expression of the complement anaphylatoxin C3a and C5a receptors on bronchial epithelial and smooth muscle cells in models of sepsis and asthma. |journal=J. Immunol. |volume=166 |issue= 3 |pages= 2025–32 |year= 2001 |pmid= 11160252 |doi=
*cite journal | author=Ames RS, Lee D, Foley JJ, "et al." |title=Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models. |journal=J. Immunol. |volume=166 |issue= 10 |pages= 6341–8 |year= 2001 |pmid= 11342658 |doi=
*cite journal | author=Kirchhoff K, Weinmann O, Zwirner J, "et al." |title=Detection of anaphylatoxin receptors on CD83+ dendritic cells derived from human skin. |journal=Immunology |volume=103 |issue= 2 |pages= 210–7 |year= 2001 |pmid= 11412308 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Reca R, Mastellos D, Majka M, "et al." |title=Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1. |journal=Blood |volume=101 |issue= 10 |pages= 3784–93 |year= 2003 |pmid= 12511407 |doi= 10.1182/blood-2002-10-3233

External links

* [http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2973 IUPHAR GPCR Database - C3a receptor]
*

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = no
update_citations = yes