GNRHR

Gonadotropin-releasing hormone receptor, also known as GNRHR, is a human gene.cite web | title = Entrez Gene: GNRHR gonadotropin-releasing hormone receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2798| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene.cite web | title = Entrez Gene: GNRHR gonadotropin-releasing hormone receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2798| accessdate = ]

ee also

* Gonadotropin-releasing hormone receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Michel U, Farnworth P, Findlay JK |title=Follistatins: more than follicle-stimulating hormone suppressing proteins. |journal=Mol. Cell. Endocrinol. |volume=91 |issue= 1-2 |pages= 1–11 |year= 1993 |pmid= 8472841 |doi=
*cite journal | author=Flanagan CA, Millar RP, Illing N |title=Advances in understanding gonadotrophin-releasing hormone receptor structure and ligand interactions. |journal=Rev. Reprod. |volume=2 |issue= 2 |pages= 113–20 |year= 1998 |pmid= 9414473 |doi=
*cite journal | author=Limonta P, Moretti RM, Marelli MM, Motta M |title=The biology of gonadotropin hormone-releasing hormone: role in the control of tumor growth and progression in humans. |journal=Frontiers in neuroendocrinology |volume=24 |issue= 4 |pages= 279–95 |year= 2004 |pmid= 14726258 |doi=
*cite journal | author=Bédécarrats GY, Kaiser UB |title=Mutations in the human gonadotropin-releasing hormone receptor: insights into receptor biology and function. |journal=Semin. Reprod. Med. |volume=25 |issue= 5 |pages= 368–78 |year= 2007 |pmid= 17710733 |doi= 10.1055/s-2007-984743
*cite journal | author=Kakar SS, Musgrove LC, Devor DC, "et al." |title=Cloning, sequencing, and expression of human gonadotropin releasing hormone (GnRH) receptor. |journal=Biochem. Biophys. Res. Commun. |volume=189 |issue= 1 |pages= 289–95 |year= 1992 |pmid= 1333190 |doi=
*cite journal | author=Kakar SS, Grizzle WE, Neill JD |title=The nucleotide sequences of human GnRH receptors in breast and ovarian tumors are identical with that found in pituitary. |journal=Mol. Cell. Endocrinol. |volume=106 |issue= 1-2 |pages= 145–9 |year= 1995 |pmid= 7534732 |doi=
*cite journal | author=Leung PC, Squire J, Peng C, "et al." |title=Mapping of the gonadotropin-releasing hormone (GnRH) receptor gene to human chromosome 4q21.2 by fluorescence in situ hybridization. |journal=Mamm. Genome |volume=6 |issue= 4 |pages= 309–10 |year= 1995 |pmid= 7613048 |doi=
*cite journal | author=Fan NC, Peng C, Krisinger J, Leung PC |title=The human gonadotropin-releasing hormone receptor gene: complete structure including multiple promoters, transcription initiation sites, and polyadenylation signals. |journal=Mol. Cell. Endocrinol. |volume=107 |issue= 2 |pages= R1–8 |year= 1995 |pmid= 7768323 |doi=
*cite journal | author=Fan NC, Jeung EB, Peng C, "et al." |title=The human gonadotropin-releasing hormone (GnRH) receptor gene: cloning, genomic organization and chromosomal assignment. |journal=Mol. Cell. Endocrinol. |volume=103 |issue= 1-2 |pages= R1–6 |year= 1994 |pmid= 7958384 |doi=
*cite journal | author=Chi L, Zhou W, Prikhozhan A, "et al." |title=Cloning and characterization of the human GnRH receptor. |journal=Mol. Cell. Endocrinol. |volume=91 |issue= 1-2 |pages= R1–6 |year= 1993 |pmid= 8386108 |doi=
*cite journal | author=Grosse R, Schöneberg T, Schultz G, Gudermann T |title=Inhibition of gonadotropin-releasing hormone receptor signaling by expression of a splice variant of the human receptor. |journal=Mol. Endocrinol. |volume=11 |issue= 9 |pages= 1305–18 |year= 1997 |pmid= 9259321 |doi=
*cite journal | author=Kakar SS |title=Molecular structure of the human gonadotropin-releasing hormone receptor gene. |journal=Eur. J. Endocrinol. |volume=137 |issue= 2 |pages= 183–92 |year= 1997 |pmid= 9272108 |doi=
*cite journal | author=de Roux N, Young J, Misrahi M, "et al." |title=A family with hypogonadotropic hypogonadism and mutations in the gonadotropin-releasing hormone receptor. |journal=N. Engl. J. Med. |volume=337 |issue= 22 |pages= 1597–602 |year= 1997 |pmid= 9371856 |doi=
*cite journal | author=Layman LC, Cohen DP, Jin M, "et al." |title=Mutations in gonadotropin-releasing hormone receptor gene cause hypogonadotropic hypogonadism. |journal=Nat. Genet. |volume=18 |issue= 1 |pages= 14–5 |year= 1998 |pmid= 9425890 |doi= 10.1038/ng0198-14
*cite journal | author=de Roux N, Young J, Brailly-Tabard S, "et al." |title=The same molecular defects of the gonadotropin-releasing hormone receptor determine a variable degree of hypogonadism in affected kindred. |journal=J. Clin. Endocrinol. Metab. |volume=84 |issue= 2 |pages= 567–72 |year= 1999 |pmid= 10022417 |doi=
*cite journal | author=Caron P, Chauvin S, Christin-Maitre S, "et al." |title=Resistance of hypogonadic patients with mutated GnRH receptor genes to pulsatile GnRH administration. |journal=J. Clin. Endocrinol. Metab. |volume=84 |issue= 3 |pages= 990–6 |year= 1999 |pmid= 10084584 |doi=
*cite journal | author=Kottler ML, Bergametti F, Carrë MC, "et al." |title=Tissue-specific pattern of variant transcripts of the human gonadotropin-releasing hormone receptor gene. |journal=Eur. J. Endocrinol. |volume=140 |issue= 6 |pages= 561–9 |year= 1999 |pmid= 10366411 |doi=
*cite journal | author=Pralong FP, Gomez F, Castillo E, "et al." |title=Complete hypogonadotropic hypogonadism associated with a novel inactivating mutation of the gonadotropin-releasing hormone receptor. |journal=J. Clin. Endocrinol. Metab. |volume=84 |issue= 10 |pages= 3811–6 |year= 1999 |pmid= 10523035 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes