RGS10

Regulator of G-protein signalling 10, also known as RGS10, is a human gene.cite web | title = Entrez Gene: RGS10 regulator of G-protein signalling 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6001| accessdate = ]

PBB_Summary
section_title =
summary_text = Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: RGS10 regulator of G-protein signalling 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6001| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hunt TW, Fields TA, Casey PJ, Peralta EG |title=RGS10 is a selective activator of G alpha i GTPase activity. |journal=Nature |volume=383 |issue= 6596 |pages= 175–7 |year= 1996 |pmid= 8774883 |doi= 10.1038/383175a0
*cite journal | author=Popov S, Yu K, Kozasa T, Wilkie TM |title=The regulators of G protein signaling (RGS) domains of RGS4, RGS10, and GAIP retain GTPase activating protein activity in vitro. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 14 |pages= 7216–20 |year= 1997 |pmid= 9207071 |doi=
*cite journal | author=Tu Y, Wang J, Ross EM |title=Inhibition of brain Gz GAP and other RGS proteins by palmitoylation of G protein alpha subunits. |journal=Science |volume=278 |issue= 5340 |pages= 1132–5 |year= 1997 |pmid= 9353196 |doi=
*cite journal | author=Tu Y, Popov S, Slaughter C, Ross EM |title=Palmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10. |journal=J. Biol. Chem. |volume=274 |issue= 53 |pages= 38260–7 |year= 2000 |pmid= 10608901 |doi=
*cite journal | author=Popov SG, Krishna UM, Falck JR, Wilkie TM |title=Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity. |journal=J. Biol. Chem. |volume=275 |issue= 25 |pages= 18962–8 |year= 2000 |pmid= 10747990 |doi= 10.1074/jbc.M001128200
*cite journal | author=Chatterjee TK, Fisher RA |title=Cytoplasmic, nuclear, and golgi localization of RGS proteins. Evidence for N-terminal and RGS domain sequences as intracellular targeting motifs. |journal=J. Biol. Chem. |volume=275 |issue= 31 |pages= 24013–21 |year= 2000 |pmid= 10791963 |doi= 10.1074/jbc.M002082200
*cite journal | author=Burgon PG, Lee WL, Nixon AB, "et al." |title=Phosphorylation and nuclear translocation of a regulator of G protein signaling (RGS10). |journal=J. Biol. Chem. |volume=276 |issue= 35 |pages= 32828–34 |year= 2001 |pmid= 11443111 |doi= 10.1074/jbc.M100960200
*cite journal | author=Gagnon AW, Murray DL, Leadley RJ |title=Cloning and characterization of a novel regulator of G protein signalling in human platelets. |journal=Cell. Signal. |volume=14 |issue= 7 |pages= 595–606 |year= 2002 |pmid= 11955952 |doi=
*cite journal | author=Castro-Fernández C, Conn PM |title=Regulation of the gonadotropin-releasing hormone receptor (GnRHR) by RGS proteins: role of the GnRHR carboxyl-terminus. |journal=Mol. Cell. Endocrinol. |volume=191 |issue= 2 |pages= 149–56 |year= 2003 |pmid= 12062898 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Oh JH, Yang JO, Hahn Y, "et al." |title=Transcriptome analysis of human gastric cancer. |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942–54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2
*cite journal | author=Lee HK, Rhee KH, Kim CW, "et al." |title=Crystallization and preliminary X-ray crystallographic analysis of human RGS10 complexed with Galphai3. |journal=Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. |volume=61 |issue= Pt 9 |pages= 831–3 |year= 2006 |pmid= 16511171 |doi= 10.1107/S1744309105023602
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes