RGS4

Regulator of G protein signaling 4 or RGS4 is a protein which regulates G protein signaling.cite web | title = Entrez Gene: RGS4 regulator of G-protein signalling 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5999| accessdate = ] A number of studies associate the RGS4 gene with schizophrenia, while some fail to detect an association.

PBB_Summary
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summary_text = Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm.cite web | title = Entrez Gene: RGS4 regulator of G-protein signalling 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5999| accessdate = ]

*cite journal | author=Druey KM, Blumer KJ, Kang VH, Kehrl JH |title=Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family. |journal=Nature |volume=379 |issue= 6567 |pages= 742–6 |year= 1996 |pmid= 8602223 |doi= 10.1038/379742a0
*cite journal | author=Berman DM, Wilkie TM, Gilman AG |title=GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits. |journal=Cell |volume=86 |issue= 3 |pages= 445–52 |year= 1996 |pmid= 8756726 |doi=
*cite journal | author=Heximer SP, Watson N, Linder ME, "et al." |title=RGS2/G0S8 is a selective inhibitor of Gqalpha function. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 26 |pages= 14389–93 |year= 1998 |pmid= 9405622 |doi=
*cite journal | author=Srinivasa SP, Bernstein LS, Blumer KJ, Linder ME |title=Plasma membrane localization is required for RGS4 function in Saccharomyces cerevisiae. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 10 |pages= 5584–9 |year= 1998 |pmid= 9576926 |doi=
*cite journal | author=Druey KM, Sullivan BM, Brown D, "et al." |title=Expression of GTPase-deficient Gialpha2 results in translocation of cytoplasmic RGS4 to the plasma membrane. |journal=J. Biol. Chem. |volume=273 |issue= 29 |pages= 18405–10 |year= 1998 |pmid= 9660808 |doi=
*cite journal | author=Faraone SV, Matise T, Svrakic D, "et al." |title=Genome scan of European-American schizophrenia pedigrees: results of the NIMH Genetics Initiative and Millennium Consortium. |journal=Am. J. Med. Genet. |volume=81 |issue= 4 |pages= 290–5 |year= 1998 |pmid= 9674973 |doi=
*cite journal | author=Wang J, Ducret A, Tu Y, "et al." |title=RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz gtpase-activating protein subfamily. |journal=J. Biol. Chem. |volume=273 |issue= 40 |pages= 26014–25 |year= 1998 |pmid= 9748280 |doi=
*cite journal | author=Shaw SH, Kelly M, Smith AB, "et al." |title=A genome-wide search for schizophrenia susceptibility genes. |journal=Am. J. Med. Genet. |volume=81 |issue= 5 |pages= 364–76 |year= 1998 |pmid= 9754621 |doi=
*cite journal | author=Posner BA, Mukhopadhyay S, Tesmer JJ, "et al." |title=Modulation of the affinity and selectivity of RGS protein interaction with G alpha subunits by a conserved asparagine/serine residue. |journal=Biochemistry |volume=38 |issue= 24 |pages= 7773–9 |year= 1999 |pmid= 10387017 |doi= 10.1021/bi9906367
*cite journal | author=Tu Y, Popov S, Slaughter C, Ross EM |title=Palmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10. |journal=J. Biol. Chem. |volume=274 |issue= 53 |pages= 38260–7 |year= 2000 |pmid= 10608901 |doi=
*cite journal | author=Moy FJ, Chanda PK, Cockett MI, "et al." |title=1H, 15N, 13C, and 13CO assignments and secondary structure determination of RGS4. |journal=J. Biomol. NMR |volume=15 |issue= 4 |pages= 339–40 |year= 2000 |pmid= 10685342 |doi=
*cite journal | author=Popov SG, Krishna UM, Falck JR, Wilkie TM |title=Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity. |journal=J. Biol. Chem. |volume=275 |issue= 25 |pages= 18962–8 |year= 2000 |pmid= 10747990 |doi= 10.1074/jbc.M001128200
*cite journal | author=Ekelund J, Lichtermann D, Hovatta I, "et al." |title=Genome-wide scan for schizophrenia in the Finnish population: evidence for a locus on chromosome 7q22. |journal=Hum. Mol. Genet. |volume=9 |issue= 7 |pages= 1049–57 |year= 2000 |pmid= 10767329 |doi=
*cite journal | author=Brzustowicz LM, Hodgkinson KA, Chow EW, "et al." |title=Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21-q22. |journal=Science |volume=288 |issue= 5466 |pages= 678–82 |year= 2000 |pmid= 10784452 |doi=
*cite journal | author=Chatterjee TK, Fisher RA |title=Cytoplasmic, nuclear, and golgi localization of RGS proteins. Evidence for N-terminal and RGS domain sequences as intracellular targeting motifs. |journal=J. Biol. Chem. |volume=275 |issue= 31 |pages= 24013–21 |year= 2000 |pmid= 10791963 |doi= 10.1074/jbc.M002082200
*cite journal | author=Chatterjee TK, Fisher RA |title=Novel alternative splicing and nuclear localization of human RGS12 gene products. |journal=J. Biol. Chem. |volume=275 |issue= 38 |pages= 29660–71 |year= 2000 |pmid= 10869340 |doi= 10.1074/jbc.M000330200
*cite journal | author=Sullivan BM, Harrison-Lavoie KJ, Marshansky V, "et al." |title=RGS4 and RGS2 bind coatomer and inhibit COPI association with Golgi membranes and intracellular transport. |journal=Mol. Biol. Cell |volume=11 |issue= 9 |pages= 3155–68 |year= 2000 |pmid= 10982407 |doi=
*cite journal | author=Dowal L, Elliott J, Popov S, "et al." |title=Determination of the contact energies between a regulator of G protein signaling and G protein subunits and phospholipase C beta 1. |journal=Biochemistry |volume=40 |issue= 2 |pages= 414–21 |year= 2001 |pmid= 11148035 |doi=
*cite journal | author=Richardson RM, Marjoram RJ, Barr AJ, Snyderman R |title=RGS4 inhibits platelet-activating factor receptor phosphorylation and cellular responses. |journal=Biochemistry |volume=40 |issue= 12 |pages= 3583–8 |year= 2001 |pmid= 11297424 |doi=

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