Hypocretin (orexin) receptor 1

Hypocretin (orexin) receptor 1, also known as HCRTR1, is a human gene.cite web | title = Entrez Gene: HCRTR1 hypocretin (orexin) receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3061| accessdate = ]

PBB_Summary
section_title =
summary_text = HCRTR1, or orexin 1 receptor (OX1R), is a G-protein coupled receptor expressed in the hypothalamus and involved in the regulation of feeding behaviour. HCRTR1 selectively binds the orexin A neuropeptide. It shares 64% identity with HCRTR2.cite web | title = Entrez Gene: HCRTR1 hypocretin (orexin) receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3061| accessdate = ]

ee also

* Orexin receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Flier JS, Maratos-Flier E |title=Obesity and the hypothalamus: novel peptides for new pathways. |journal=Cell |volume=92 |issue= 4 |pages= 437–40 |year= 1998 |pmid= 9491885 |doi=
*cite journal | author=Willie JT, Chemelli RM, Sinton CM, Yanagisawa M |title=To eat or to sleep? Orexin in the regulation of feeding and wakefulness. |journal=Annu. Rev. Neurosci. |volume=24 |issue= |pages= 429–58 |year= 2001 |pmid= 11283317 |doi= 10.1146/annurev.neuro.24.1.429
*cite journal | author=Hungs M, Mignot E |title=Hypocretin/orexin, sleep and narcolepsy. |journal=Bioessays |volume=23 |issue= 5 |pages= 397–408 |year= 2001 |pmid= 11340621 |doi= 10.1002/bies.1058
*cite journal | author=de Lecea L, Kilduff TS, Peyron C, "et al." |title=The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 1 |pages= 322–7 |year= 1998 |pmid= 9419374 |doi=
*cite journal | author=Sakurai T, Amemiya A, Ishii M, "et al." |title=Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. |journal=Cell |volume=92 |issue= 4 |pages= 573–85 |year= 1998 |pmid= 9491897 |doi=
*cite journal | author=Sakurai T, Amemiya A, Ishii M, "et al." |title=Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. |journal=Cell |volume=92 |issue= 5 |pages= 1 page following 696 |year= 1998 |pmid= 9527442 |doi=
*cite journal | author=Peyron C, Faraco J, Rogers W, "et al." |title=A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. |journal=Nat. Med. |volume=6 |issue= 9 |pages= 991–7 |year= 2000 |pmid= 10973318 |doi= 10.1038/79690
*cite journal | author=Blanco M, López M, GarcIa-Caballero T, "et al." |title=Cellular localization of orexin receptors in human pituitary. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 7 |pages= 1616–9 |year= 2001 |pmid= 11443222 |doi=
*cite journal | author=Olafsdóttir BR, Rye DB, Scammell TE, "et al." |title=Polymorphisms in hypocretin/orexin pathway genes and narcolepsy. |journal=Neurology |volume=57 |issue= 10 |pages= 1896–9 |year= 2002 |pmid= 11723285 |doi=
*cite journal | author=Wieland HA, Söll RM, Doods HN, "et al." |title=The SK-N-MC cell line expresses an orexin binding site different from recombinant orexin 1-type receptor. |journal=Eur. J. Biochem. |volume=269 |issue= 4 |pages= 1128–35 |year= 2002 |pmid= 11856342 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Hilairet S, Bouaboula M, Carrière D, "et al." |title=Hypersensitization of the Orexin 1 receptor by the CB1 receptor: evidence for cross-talk blocked by the specific CB1 antagonist, SR141716. |journal=J. Biol. Chem. |volume=278 |issue= 26 |pages= 23731–7 |year= 2003 |pmid= 12690115 |doi= 10.1074/jbc.M212369200
*cite journal | author=Karteris E, Chen J, Randeva HS |title=Expression of human prepro-orexin and signaling characteristics of orexin receptors in the male reproductive system. |journal=J. Clin. Endocrinol. Metab. |volume=89 |issue= 4 |pages= 1957–62 |year= 2004 |pmid= 15070969 |doi=
*cite journal | author=Holmqvist T, Johansson L, Ostman M, "et al." |title=OX1 orexin receptors couple to adenylyl cyclase regulation via multiple mechanisms. |journal=J. Biol. Chem. |volume=280 |issue= 8 |pages= 6570–9 |year= 2005 |pmid= 15611118 |doi= 10.1074/jbc.M407397200
*cite journal | author=Spinazzi R, Rucinski M, Neri G, "et al." |title=Preproorexin and orexin receptors are expressed in cortisol-secreting adrenocortical adenomas, and orexins stimulate in vitro cortisol secretion and growth of tumor cells. |journal=J. Clin. Endocrinol. Metab. |volume=90 |issue= 6 |pages= 3544–9 |year= 2005 |pmid= 15797953 |doi= 10.1210/jc.2004-2385
*cite journal | author=Meerabux J, Iwayama Y, Sakurai T, "et al." |title=Association of an orexin 1 receptor 408Val variant with polydipsia-hyponatremia in schizophrenic subjects. |journal=Biol. Psychiatry |volume=58 |issue= 5 |pages= 401–7 |year= 2005 |pmid= 15978554 |doi= 10.1016/j.biopsych.2005.04.015
*cite journal | author=Ziolkowska A, Spinazzi R, Albertin G, "et al." |title=Orexins stimulate glucocorticoid secretion from cultured rat and human adrenocortical cells, exclusively acting via the OX1 receptor. |journal=J. Steroid Biochem. Mol. Biol. |volume=96 |issue= 5 |pages= 423–9 |year= 2006 |pmid= 16157481 |doi= 10.1016/j.jsbmb.2005.05.003

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