Hypocretin (orexin) receptor 2

Hypocretin (orexin) receptor 2, also known as HCRTR2, is a human gene.cite web | title = Entrez Gene: HCRTR2 hypocretin (orexin) receptor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3062| accessdate = ]

PBB_Summary
section_title =
summary_text = HCRTR2 is a G-protein coupled receptor expressed exclusively in the brain. It has 64% identity with HCRTR1. HCRTR2 binds both orexin A and orexin B neuropeptides. HCRTR2 is involved in the central feedback mechanism that regulates feeding behaviour.cite web | title = Entrez Gene: HCRTR2 hypocretin (orexin) receptor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3062| accessdate = ]

ee also

* Orexin receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Flier JS, Maratos-Flier E |title=Obesity and the hypothalamus: novel peptides for new pathways. |journal=Cell |volume=92 |issue= 4 |pages= 437–40 |year= 1998 |pmid= 9491885 |doi=
*cite journal | author=Willie JT, Chemelli RM, Sinton CM, Yanagisawa M |title=To eat or to sleep? Orexin in the regulation of feeding and wakefulness. |journal=Annu. Rev. Neurosci. |volume=24 |issue= |pages= 429–58 |year= 2001 |pmid= 11283317 |doi= 10.1146/annurev.neuro.24.1.429
*cite journal | author=Hungs M, Mignot E |title=Hypocretin/orexin, sleep and narcolepsy. |journal=Bioessays |volume=23 |issue= 5 |pages= 397–408 |year= 2001 |pmid= 11340621 |doi= 10.1002/bies.1058
*cite journal | author=de Lecea L, Kilduff TS, Peyron C, "et al." |title=The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 1 |pages= 322–7 |year= 1998 |pmid= 9419374 |doi=
*cite journal | author=Sakurai T, Amemiya A, Ishii M, "et al." |title=Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. |journal=Cell |volume=92 |issue= 4 |pages= 573–85 |year= 1998 |pmid= 9491897 |doi=
*cite journal | author=Sakurai T, Amemiya A, Ishii M, "et al." |title=Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. |journal=Cell |volume=92 |issue= 5 |pages= 1 page following 696 |year= 1998 |pmid= 9527442 |doi=
*cite journal | author=Peyron C, Faraco J, Rogers W, "et al." |title=A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. |journal=Nat. Med. |volume=6 |issue= 9 |pages= 991–7 |year= 2000 |pmid= 10973318 |doi= 10.1038/79690
*cite journal | author=Wright GJ, Puklavec MJ, Willis AC, "et al." |title=Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function. |journal=Immunity |volume=13 |issue= 2 |pages= 233–42 |year= 2000 |pmid= 10981966 |doi=
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Mazzocchi G, Malendowicz LK, Gottardo L, "et al." |title=Orexin A stimulates cortisol secretion from human adrenocortical cells through activation of the adenylate cyclase-dependent signaling cascade. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 2 |pages= 778–82 |year= 2001 |pmid= 11158046 |doi=
*cite journal | author=Blanco M, López M, García-Caballero T, "et al." |title=Cellular localization of orexin receptors in human pituitary. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 4 |pages= 1616–9 |year= 2001 |pmid= 11297593 |doi=
*cite journal | author=Blanco M, López M, GarcIa-Caballero T, "et al." |title=Cellular localization of orexin receptors in human pituitary. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 7 |pages= 1616–9 |year= 2001 |pmid= 11443222 |doi=
*cite journal | author=Karteris E, Randeva HS, Grammatopoulos DK, "et al." |title=Expression and coupling characteristics of the CRH and orexin type 2 receptors in human fetal adrenals. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 9 |pages= 4512–9 |year= 2001 |pmid= 11549701 |doi=
*cite journal | author=Randeva HS, Karteris E, Grammatopoulos D, Hillhouse EW |title=Expression of orexin-A and functional orexin type 2 receptors in the human adult adrenals: implications for adrenal function and energy homeostasis. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 10 |pages= 4808–13 |year= 2001 |pmid= 11600545 |doi=
*cite journal | author=Olafsdóttir BR, Rye DB, Scammell TE, "et al." |title=Polymorphisms in hypocretin/orexin pathway genes and narcolepsy. |journal=Neurology |volume=57 |issue= 10 |pages= 1896–9 |year= 2002 |pmid= 11723285 |doi=
*cite journal | author=Blanco M, García-Caballero T, Fraga M, "et al." |title=Cellular localization of orexin receptors in human adrenal gland, adrenocortical adenomas and pheochromocytomas. |journal=Regul. Pept. |volume=104 |issue= 1-3 |pages= 161–5 |year= 2002 |pmid= 11830291 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899

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