Nelivaptan

Nelivaptan

Systematic (IUPAC) name
(2S,4R)-1-[(3R)-5-chloro-1-(2,4-dimethoxyphenyl)sulfonyl-3-(2-met​hoxyphenyl)-2-oxo-indolin-3-yl]-4-hydroxy-N,N-dimethyl-pyrrolidin​e-2-carboxamide
Clinical data
Pregnancy cat.	?
Legal status	?
Routes	Oral
Identifiers
CAS number	439687-69-1 N
ATC code	None
PubChem	CID 9895468
ChemSpider	8071134 Y
UNII	3TY57MQ4OA Y
ChEMBL	CHEMBL582857 Y
Chemical data
Formula	C30H32ClN3O8S
Mol. mass	630.11 g/mol
InChI InChI=1S/C30H32ClN3O8S/c1-32(2)28(36)24-15-19(35)17-33(24)30(21-8-6-7-9-25(21)41-4)22-14-18(31)10-12-23(22)34(29(30)37)43(38,39)27-13-11-20(40-3)16-26(27)42-5/h6-14,16,19,24,35H,15,17H2,1-5H3/t19-,24+,30+/m1/s1 Y Key:NJXZWIIMWNEOGJ-WEWKHQNJSA-N Y
N(what is this?)  (verify)

Nelivaptan (INN^[1]), codenamed SSR-149,415, is a selective and orally active non-peptide vasopressin receptor antagonist selective for the V1b subtype.^[2] The drug had entered clinical trials for treatment of anxiety and depression.^[3] In July 2008, Sanofi-Aventis announced that further development of this drug had been halted.^[4]

References

1. ^ World Health Organization (2007). "International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 98". WHO Drug Information 21 (4): 341. http://www.who.int/medicines/publications/druginformation/innlists/P-List98.pdf. 
2. ^ Griebel G, Simiand J, Serradeil-Le Gal C, Wagnon J, Pascal M, Scatton B, Maffrand JP, Soubrie P (2002). "Anxiolytic- and antidepressant-like effects of the non-peptide vasopressin V1b receptor antagonist, SSR149415, suggest an innovative approach for the treatment of stress-related disorders". Proc. Natl. Acad. Sci. U.S.A. 99 (9): 6370–5. doi:10.1073/pnas.092012099. PMC 122955. PMID 11959912. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=122955. 
3. ^ Serradeil-Le Gal C, Wagnon J, Tonnerre B, Roux R, Garcia G, Griebel G, Aulombard A (2005). "An overview of SSR149415, a selective nonpeptide vasopressin V(1b) receptor antagonist for the treatment of stress-related disorders". CNS drug reviews 11 (1): 53–68. doi:10.1111/j.1527-3458.2005.tb00035.x. PMID 15867952. 
4. ^ "Second-quarter 2008 results". Press Release. Sanofi-Aventis. 2008-07-31. http://en.sanofi-aventis.com/binaries/20080731_results2008_Q2_CP_EN_tcm28-20271.pdf. Retrieved 2009-06-10. "It has been decided to discontinue the development of amibegron and SSR 149415 (a V1B receptor antagonist)." 

External links

• MeSH SSR149415

This hormonal preparation article is a stub. You can help Wikipedia by expanding it.v · Categories: Systemic hormonal preparation stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем написать реферат House of Nelipić Kvinnan bakom allt Look at other dictionaries: nelivaptan — noun A certain vaptan drug originally proposed for the treatment of anxiety and depression but whose development was halted in 2008 …   Wiktionary Oxytocin — Systematic (IUPAC) name 1 ({(4R,7S,10S …   Wikipedia Desmopressin — Systematic (IUPAC) name (2S) N [(2R) 1 [(2 amino 2 oxoethyl)amino] 5 (diaminomethylideneamino) 1 oxopentan 2 yl] 1 [(4R,7S,10S,13S,16S) 7 (2 amino 2 oxoethyl) 10 (3 amino 3 oxopropyl) 16 [(4 hydroxyphenyl) …   Wikipedia Conivaptan — Systematic (IUPAC) name N (4 (4,5 dihydro 2 methylimidazo[4,5 d][1]benzazepin 6(1H) yl)carbonyl)phenyl) (1,1 biphenyl) 2 carboxamide Clinical data …   Wikipedia Felypressin — IUPAC name 1 [19 Amino 13,16 dibenzyl 10 (2 carbamoyl ethyl) 7 carbamoylmethyl 6,9,12,15,18 pentaoxo 1,2 dithia 5,8,11,14,17 pentaaz …   Wikipedia Cosyntropin — Identifiers CAS number 16960 16 0 …   Wikipedia Carbetocin — Systematic (IUPAC) name (2S) 1 [(3S,6S,9S,12S,15S) 12 [(2S) butan 2 yl] 9 (2 carbamoylethyl) 6 (carbamoylmethyl) 15 [(4 hydroxyphenyl)methyl] 16 methyl 5,8,11,14,17 pentaoxo 1 thia 4,7,10,13,16 pentazacycloicosane …   Wikipedia Demoxytocin — IUPAC name 2 [(1 {[13 (butan 2 yl) 10 (2 carbamoylethyl) 7 (carbamoylmethyl) 16 [(4 hydroxyphenyl)methyl] 6,9,12,15,18 pentaoxo 1,2 dit …   Wikipedia Adrenocorticotropic hormone — proopiomelanocortin (adrenocorticotropin/ beta lipotropin/ alpha melanocyte stimulating hormone/ beta melanocyte stimulating hormone/ beta endorphin) proopiomelanocortin derivatives POMC     …   Wikipedia Corticotropin-releasing hormone — PDB rendering based on 1go9 …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”