Galanin receptor 2

Galanin receptor 2, also known as GALR2, is a human gene.cite web | title = Entrez Gene: GALR2 galanin receptor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8811| accessdate = ]

PBB_Summary
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summary_text = Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways.cite web | title = Entrez Gene: GALR2 galanin receptor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8811| accessdate = ]

ee also

* Galanin receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bloomquist BT, Beauchamp MR, Zhelnin L, "et al." |title=Cloning and expression of the human galanin receptor GalR2. |journal=Biochem. Biophys. Res. Commun. |volume=243 |issue= 2 |pages= 474–9 |year= 1998 |pmid= 9480833 |doi= 10.1006/bbrc.1998.8133
*cite journal | author=Fathi Z, Battaglino PM, Iben LG, "et al." |title=Molecular characterization, pharmacological properties and chromosomal localization of the human GALR2 galanin receptor. |journal=Brain Res. Mol. Brain Res. |volume=58 |issue= 1-2 |pages= 156–69 |year= 1998 |pmid= 9685625 |doi=
*cite journal | author=Kolakowski LF, O'Neill GP, Howard AD, "et al." |title=Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3. |journal=J. Neurochem. |volume=71 |issue= 6 |pages= 2239–51 |year= 1998 |pmid= 9832121 |doi=
*cite journal | author=Borowsky B, Walker MW, Huang LY, "et al." |title=Cloning and characterization of the human galanin GALR2 receptor. |journal=Peptides |volume=19 |issue= 10 |pages= 1771–81 |year= 1999 |pmid= 9880084 |doi=
*cite journal | author=Berger A, Tuechler C, Almer D, "et al." |title=Elevated expression of galanin receptors in childhood neuroblastic tumors. |journal=Neuroendocrinology |volume=75 |issue= 2 |pages= 130–8 |year= 2002 |pmid= 11867941 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Berger A, Lang R, Moritz K, "et al." |title=Galanin receptor subtype GalR2 mediates apoptosis in SH-SY5Y neuroblastoma cells. |journal=Endocrinology |volume=145 |issue= 2 |pages= 500–7 |year= 2004 |pmid= 14592962 |doi= 10.1210/en.2003-0649
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Belfer I, Hipp H, Bollettino A, "et al." |title=Alcoholism is associated with GALR3 but not two other galanin receptor genes. |journal=Genes Brain Behav. |volume=6 |issue= 5 |pages= 473–81 |year= 2007 |pmid= 17083333 |doi= 10.1111/j.1601-183X.2006.00275.x

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