EDG6

EDG6 (endothelial differentiation gene 1) is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P₄.cite web | title = Entrez Gene: EDG6 endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8698| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a member of the endothelial differentiation, G-protein-coupled (EDG)) receptor gene family. EDG receptors bind lysophospholipids or lysosphingolipids as ligands, and are involved in cell signalling in many different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue.cite web | title = Entrez Gene: EDG6 endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8698| accessdate = ]

ee also

* Lysophospholipid receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Gräler MH, Bernhardt G, Lipp M |title=EDG6, a novel G-protein-coupled receptor related to receptors for bioactive lysophospholipids, is specifically expressed in lymphoid tissue. |journal=Genomics |volume=53 |issue= 2 |pages= 164–9 |year= 1998 |pmid= 9790765 |doi= 10.1006/geno.1998.5491
*cite journal | author=Yamazaki Y, Kon J, Sato K, "et al." |title=Edg-6 as a putative sphingosine 1-phosphate receptor coupling to Ca(2+) signaling pathway. |journal=Biochem. Biophys. Res. Commun. |volume=268 |issue= 2 |pages= 583–9 |year= 2000 |pmid= 10679247 |doi= 10.1006/bbrc.2000.2162
*cite journal | author=Van Brocklyn JR, Gräler MH, Bernhardt G, "et al." |title=Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6. |journal=Blood |volume=95 |issue= 8 |pages= 2624–9 |year= 2000 |pmid= 10753843 |doi=
*cite journal | author=Idzko M, Panther E, Corinti S, "et al." |title=Sphingosine 1-phosphate induces chemotaxis of immature and modulates cytokine-release in mature human dendritic cells for emergence of Th2 immune responses. |journal=FASEB J. |volume=16 |issue= 6 |pages= 625–7 |year= 2002 |pmid= 11919175 |doi=
*cite journal | author=Kveberg L, Bryceson Y, Inngjerdingen M, "et al." |title=Sphingosine 1 phosphate induces the chemotaxis of human natural killer cells. Role for heterotrimeric G proteins and phosphoinositide 3 kinases. |journal=Eur. J. Immunol. |volume=32 |issue= 7 |pages= 1856–64 |year= 2002 |pmid= 12115604 |doi= 10.1002/1521-4141(200207)32:7<1856::AID-IMMU1856>3.0.CO;2-B |doilabel=10.1002/1521-4141(200207)32:71856::AID-IMMU18563.0.CO;2-B
*cite journal | author=Candelore MR, Wright MJ, Tota LM, "et al." |title=Phytosphingosine 1-phosphate: a high affinity ligand for the S1P(4)/Edg-6 receptor. |journal=Biochem. Biophys. Res. Commun. |volume=297 |issue= 3 |pages= 600–6 |year= 2002 |pmid= 12270137 |doi=
*cite journal | author=Contos JJ, Ye X, Sah VP, Chun J |title=Tandem genomic arrangement of a G protein (Gna15) and G protein-coupled receptor (s1p(4)/lp(C1)/Edg6) gene. |journal=FEBS Lett. |volume=531 |issue= 1 |pages= 99–102 |year= 2002 |pmid= 12401211 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Vogler R, Sauer B, Kim DS, "et al." |title=Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing. |journal=J. Invest. Dermatol. |volume=120 |issue= 4 |pages= 693–700 |year= 2003 |pmid= 12648236 |doi= 10.1046/j.1523-1747.2003.12096.x
*cite journal | author=Gräler MH, Grosse R, Kusch A, "et al." |title=The sphingosine 1-phosphate receptor S1P4 regulates cell shape and motility via coupling to Gi and G12/13. |journal=J. Cell. Biochem. |volume=89 |issue= 3 |pages= 507–19 |year= 2003 |pmid= 12761884 |doi= 10.1002/jcb.10537
*cite journal | author=Kyi CS, Key SJ, Lloyd TW |title=Use of a nasogastric catheter to prevent soft tissue entanglement of the externally ported distractor arm. |journal=International journal of oral and maxillofacial surgery |volume=32 |issue= 3 |pages= 337–8 |year= 2003 |pmid= 12767884 |doi= 10.1054/ijom.2003.0364
*cite journal | author=Holdsworth G, Osborne DA, Pham TT, "et al." |title=A single amino acid determines preference between phospholipids and reveals length restriction for activation of the S1P4 receptor. |journal=BMC Biochem. |volume=5 |issue= |pages= 12 |year= 2005 |pmid= 15298705 |doi= 10.1186/1471-2091-5-12
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209

External links

* [http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1338 IUPHAR GPCR Database - Lysophospholipid receptors]
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