Galanin receptor 1

Galanin receptor 1, also known as GALR1, is a human gene.cite web | title = Entrez Gene: GALR1 galanin receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2587| accessdate = ]

PBB_Summary
section_title =
summary_text = The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart.cite web | title = Entrez Gene: GALR1 galanin receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2587| accessdate = ]

ee also

* Galanin receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Habert-Ortoli E, Amiranoff B, Loquet I, "et al." |title=Molecular cloning of a functional human galanin receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 21 |pages= 9780–3 |year= 1994 |pmid= 7524088 |doi=
*cite journal | author=Walli R, Schäfer H, Morys-Wortmann C, "et al." |title=Identification and biochemical characterization of the human brain galanin receptor. |journal=J. Mol. Endocrinol. |volume=13 |issue= 3 |pages= 347–56 |year= 1995 |pmid= 7534460 |doi=
*cite journal | author=Kask K, Berthold M, Kahl U, "et al." |title=Delineation of the peptide binding site of the human galanin receptor. |journal=EMBO J. |volume=15 |issue= 2 |pages= 236–44 |year= 1996 |pmid= 8617199 |doi=
*cite journal | author=Lorimer DD, Benya RV |title=Cloning and quantification of galanin-1 receptor expression by mucosal cells lining the human gastrointestinal tract. |journal=Biochem. Biophys. Res. Commun. |volume=222 |issue= 2 |pages= 379–85 |year= 1996 |pmid= 8670213 |doi= 10.1006/bbrc.1996.0752
*cite journal | author=Nicholl J, Kofler B, Sutherland GR, "et al." |title=Assignment of the gene encoding human galanin receptor (GALNR) to 18q23 by in situ hybridization. |journal=Genomics |volume=30 |issue= 3 |pages= 629–30 |year= 1997 |pmid= 8825658 |doi= 10.1006/geno.1995.1292
*cite journal | author=Sullivan KA, Shiao LL, Cascieri MA |title=Pharmacological characterization and tissue distribution of the human and rat GALR1 receptors. |journal=Biochem. Biophys. Res. Commun. |volume=233 |issue= 3 |pages= 823–8 |year= 1997 |pmid= 9168941 |doi= 10.1006/bbrc.1997.6542
*cite journal | author=Jacoby AS, Webb GC, Liu ML, "et al." |title=Structural organization of the mouse and human GALR1 galanin receptor genes (Galnr and GALNR) and chromosomal localization of the mouse gene. |journal=Genomics |volume=45 |issue= 3 |pages= 496–508 |year= 1998 |pmid= 9367674 |doi= 10.1006/geno.1997.4960
*cite journal | author=Lorimer DD, Matkowskj K, Benya RV |title=Cloning, chromosomal location, and transcriptional regulation of the human galanin-1 receptor gene (GALN1R). |journal=Biochem. Biophys. Res. Commun. |volume=241 |issue= 2 |pages= 558–64 |year= 1998 |pmid= 9425310 |doi= 10.1006/bbrc.1997.7838
*cite journal | author=Fitzgerald LW, Patterson JP, Conklin DS, "et al." |title=Pharmacological and biochemical characterization of a recombinant human galanin GALR1 receptor: agonist character of chimeric galanin peptides. |journal=J. Pharmacol. Exp. Ther. |volume=287 |issue= 2 |pages= 448–56 |year= 1998 |pmid= 9808667 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Henson BS, Neubig RR, Jang I, "et al." |title=Galanin receptor 1 has anti-proliferative effects in oral squamous cell carcinoma. |journal=J. Biol. Chem. |volume=280 |issue= 24 |pages= 22564–71 |year= 2005 |pmid= 15767248 |doi= 10.1074/jbc.M414589200
*cite journal | author=Schäuble N, Reichwald K, Grassl W, "et al." |title=Human galanin (GAL) and galanin 1 receptor (GALR1) variations are not involved in fat intake and early onset obesity. |journal=J. Nutr. |volume=135 |issue= 6 |pages= 1387–92 |year= 2005 |pmid= 15930442 |doi=
*cite journal | author=Belfer I, Hipp H, Bollettino A, "et al." |title=Alcoholism is associated with GALR3 but not two other galanin receptor genes. |journal=Genes Brain Behav. |volume=6 |issue= 5 |pages= 473–81 |year= 2007 |pmid= 17083333 |doi= 10.1111/j.1601-183X.2006.00275.x

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