Cosyntropin

Cosyntropin
Identifiers
CAS number	16960-16-0
PubChem	16129674
UNII	72YY86EA29
DrugBank	DB01284
ChEMBL	CHEMBL1201443
Jmol-3D images	Image 1
SMILES CC(C)[C@@H](C(=O)NCC(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N3CCC[C@H]3C(=O)O)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC7=CC=CC=C7)NC(=O)[C@H](CC8=CN=CN8)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@H](CC9=CC=C(C=C9)O)NC(=O)C(CO)N
Properties
Molecular formula	C136H210N40O31S
Molar mass	2933.44 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Cosyntropin (tradename Cortrosyn) is a synthetic derivative of ACTH that is used in the ACTH stimulation test to evaluate and diagnose cortisol disorders. Cosyntropin contains the first 24 (of a total 39) amino acids of ACTH but retains full function.^[1]

In patients with low cortisol levels or symptoms of adrenocortical insufficiency, cosyntropin can be used to diagnose Addison's disease. A failure for serum cortisol levels to increase after administration of cosyntropin makes a diagnosis of primary adrenocortical insufficiency more likely. An increase in cortisol upon administration of cosyntropin rules out the condition.

See also

• Tetracosactide, a similar drug

References

1. ^ Cortrosyn information

External links

• MeSH Cosyntropin