Mozavaptan

Mozavaptan: Mozavaptan

Systematic (IUPAC) name

N-[4-(5-Dimethylamino-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)phenyl]-2-methylbenzamide

Clinical data

Pregnancy cat. ?

Legal status ℞ Prescription only

Routes Oral

Identifiers

CAS number 137975-06-5

ATC code None

PubChem CID 119369

ChemSpider 106618^Y

UNII 17OJ42922Y^Y

Chemical data

Formula C₂₇H₂₉N₃O₂

Mol. mass 427.53 g/mol

SMILES eMolecules & PubChem

InChI

InChI=1S/C27H29N3O2/c1-19-9-4-5-10-22(19)26(31)28-21-16-14-20(15-17-21)27(32)30-18-8-13-24(29(2)3)23-11-6-7-12-25(23)30/h4-7,9-12,14-17,24H,8,13,18H2,1-3H3,(H,28,31)^Y
Key:WRNXUQJJCIZICJ-UHFFFAOYSA-N^Y

Y(what is this?) (verify)

Mozavaptan (INN) is a vasopressin receptor antagonist marketed by Otsuka. In Japan, it was approved in October 2006 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH) due to ADH producing tumors.

References

H. Spreitzer (November 20, 2006). "Neue Wirkstoffe - Conivaptan" (in German). Österreichische Apothekerzeitung (24/2006).

Prous Science: Molecule of the Month November 2006

v · d · eAntihypertensives: diuretics (C03)

Sulfonamides
(except EA)

CA inhibitors (at PT)

Acetazolamide

Loop (Na-K-Cl at AL)

Furosemide^# • Bumetanide • Torasemide • Etacrynic acid

Thiazides (Na-Cl at DCT,
Calcium-sparing)

Hydrochlorothiazide^# • Bendroflumethiazide • Hydroflumethiazide • Chlorothiazide • Polythiazide • Trichlormethiazide • Cyclopenthiazide • Methyclothiazide • Cyclothiazide • Mebutizide

Thiazide-likes (primarily DCT)

Quinethazone • Clopamide • Chlortalidone • Mefruside • Clofenamide • Metolazone • Meticrane • Xipamide • Indapamide • Clorexolone • Fenquizone

Potassium-sparing (at CD)

ESC blockers

Amiloride^# • Triamterene • Benzamil

Aldosterone antagonists

Spironolactone^# • Eplerenone • Potassium canrenoate • Canrenone

Osmotic diuretics (PT, DL)
Mannitol^# • Urea

VAs (DCT and CD)

vaptans: Conivaptan • Mozavaptan • Satavaptan • Tolvaptan
tetracyclines: Demeclocycline

Other
mercurial diuretic (Mersalyl) • Theobromine • Cicletanine

^#WHO-EM. ^‡Withdrawn from market. Clinical trials: ^†Phase III. ^§Never to phase III

M: VAS

anat(a:h/u/t/a/l,v:h/u/t/a/l)/phys/devp/cell/prot

noco/syva/cong/lyvd/tumr, sysi/epon, injr

proc, drug(C2s+n/3/4/5/7/8/9)

v · d · eNeuropeptidergics

Cholecystokinin

CCK_A

Agonists: Cholecystokinin • CCK-4
Antagonists: Asperlicin • Proglumide • Lorglumide • Devazepide • Dexloxiglumide

CCK_B

Agonists: Cholecystokinin • CCK-4 • Gastrin
Antagonists: Proglumide • CI-988

CRH

CRF₁

Agonists: Corticotropin releasing hormone
Antagonists: Antalarmin • CP-154,526 • Pexacerfont

CRF₂

Agonists: Corticotropin releasing hormone

Galanin

GAL₁

Agonists: Galanin • Galanin-like peptide • Galmic • Galnon

GAL₂

Agonists: Galanin • Galanin-like peptide • Galmic • Galnon

GAL₃

Agonists: Galanin • Galmic • Galnon

Ghrelin
Agonists: Ghrelin • Capromorelin • MK-677 • Sermorelin • SM-130,686 • Tabimorelin

MCH

MCH₁

Agonists: Melanin concentrating hormone
Antagonists: ATC-0175 • GW-803,430 • NGD-4715 • SNAP-7941 • SNAP-94847

MCH₂

Agonists: Melanin concentrating hormone

Melanocortin

MC₁

Agonists: alpha-MSH • Afamelanotide • Bremelanotide • Melanotan II
Antagonists: Agouti signalling peptide

MC₂

Agonists: ACTH • Cosyntropin • Tetracosactide

MC₃

Agonists: alpha-MSH • Bremelanotide • Melanotan II

MC₄

Agonists: alpha-MSH • Bremelanotide • Melanotan II • THIQ
Antagonists: Agouti-related peptide

MC₅

Agonists: alpha-MSH • Melanotan II

Neuropeptide S
Agonists: Neuropeptide S
Antagonists: SHA-68

Neuropeptide Y

Y₁

Agonists: Neuropeptide Y • Peptide YY
Antagonists: BIBP-3226

Y₂

Agonists: Neuropeptide Y • Peptide YY
Antagonists: BIIE-0246

Y₄

Agonists: Neuropeptide Y • Pancreatic polypeptide • Peptide YY
Antagonists: UR-AK49

Y₅

Agonists: Neuropeptide Y • Peptide YY
Antagonists: Lu AA-33810

Neurotensin

NTS₁

Agonists: Neurotensin • Neuromedin N
Antagonists: SR-48692 • SR-142,948

NTS₂

Agonists: Neurotensin
Antagonists: Levocabastine • SR-142,948

Opioid
see Template:Opioids

Orexin

OX₁

Agonists: Orexin-A
Antagonists: Almorexant • SB-334,867 • SB-408,124 • SB-649,868 • Suvorexant

OX₂

Agonists: Orexin-A
Antagonists: Almorexant • SB-649,868 • Suvorexant • TCS-OX2-29

Oxytocin
Agonists: Carbetocin • Demoxytocin • Oxytocin • WAY-267,464
Antagonists: Atosiban • Epelsiban • L-371,257 • L-368,899

Tachykinin

NK₁

Agonists: Substance P
Antagonists: Aprepitant • Befetupitant • Casopitant • CI-1021 • CP-96,345 • CP-99,994 • CP-122,721 • Dapitant • Ezlopitant • FK-888 • Fosaprepitant • GR-203,040 • GW-597,599 • HSP-117 • L-733,060 • L-741,671 • L-743,310 • L-758,298 • Lanepitant • LY-306,740 • Maropitant • Netupitant • NKP-608 • Nolpitantium • Orvepitant • RP-67,580 • SDZ NKT 343 • Vestipitant • Vofopitant

NK₂

Agonists: Neurokinin A
Antagonists: GR-159,897 • Ibodutant • Saredutant

NK₃

Agonists: Neurokinin B
Antagonists: Osanetant • Talnetant

Vasopressin

V_1A

Agonists: Desmopressin • Felypressin • Ornipressin • Terlipressin • Vasopressin
Antagonists: Conivaptan • Demeclocycline • Relcovaptan

V_1B

Agonists: Felypressin • Ornipressin • Terlipressin • Vasopressin
Antagonists: Demeclocycline • Nelivaptan

V₂

Agonists: Desmopressin • Ornipressin • Vasopressin
Antagonists: Conivaptan • Demeclocycline • Lixivaptan • Mozavaptan • Satavaptan • Tolvaptan

Categories:
Diuretics
Hormonal agents
Benzanilides
Amides
Benzazepines
Antihypertensive agent stubs

Mozavaptan

Systematic (IUPAC) name
N-[4-(5-Dimethylamino-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)phenyl]-2-methylbenzamide
Clinical data
Pregnancy cat.	?
Legal status	℞ Prescription only
Routes	Oral
Identifiers
CAS number	137975-06-5
ATC code	None
PubChem	CID 119369
ChemSpider	106618^Y
UNII	17OJ42922Y^Y
Chemical data
Formula	C₂₇H₂₉N₃O₂
Mol. mass	427.53 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C27H29N3O2/c1-19-9-4-5-10-22(19)26(31)28-21-16-14-20(15-17-21)27(32)30-18-8-13-24(29(2)3)23-11-6-7-12-25(23)30/h4-7,9-12,14-17,24H,8,13,18H2,1-3H3,(H,28,31)^Y Key:WRNXUQJJCIZICJ-UHFFFAOYSA-N^Y
Y(what is this?) (verify)

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mozavaptan — noun A certain vaptan drug used to treat hyponatremia caused by SIADH … Wiktionary
Conivaptan — Systematic (IUPAC) name N (4 (4,5 dihydro 2 methylimidazo[4,5 d][1]benzazepin 6(1H) yl)carbonyl)phenyl) (1,1 biphenyl) 2 carboxamide Clinical data … Wikipedia
Oxytocin — Systematic (IUPAC) name 1 ({(4R,7S,10S … Wikipedia
Desmopressin — Systematic (IUPAC) name (2S) N [(2R) 1 [(2 amino 2 oxoethyl)amino] 5 (diaminomethylideneamino) 1 oxopentan 2 yl] 1 [(4R,7S,10S,13S,16S) 7 (2 amino 2 oxoethyl) 10 (3 amino 3 oxopropyl) 16 [(4 hydroxyphenyl) … Wikipedia
Demeclocycline — Systematic (IUPAC) name (2E,4S,4aS,5aS,6S,12aS) 2 [amino(hydroxy)methylidene] 7 chloro 4 (dimethylamino) 6,10,11,12a tetrahydroxy 1,2,3,4,4a,5,5a,6,12,12a decahydrotetracene 1,3,12 trione … Wikipedia
Felypressin — IUPAC name 1 [19 Amino 13,16 dibenzyl 10 (2 carbamoyl ethyl) 7 carbamoylmethyl 6,9,12,15,18 pentaoxo 1,2 dithia 5,8,11,14,17 pentaaz … Wikipedia
Cosyntropin — Identifiers CAS number 16960 16 0 … Wikipedia
Carbetocin — Systematic (IUPAC) name (2S) 1 [(3S,6S,9S,12S,15S) 12 [(2S) butan 2 yl] 9 (2 carbamoylethyl) 6 (carbamoylmethyl) 15 [(4 hydroxyphenyl)methyl] 16 methyl 5,8,11,14,17 pentaoxo 1 thia 4,7,10,13,16 pentazacycloicosane … Wikipedia
Demoxytocin — IUPAC name 2 [(1 {[13 (butan 2 yl) 10 (2 carbamoylethyl) 7 (carbamoylmethyl) 16 [(4 hydroxyphenyl)methyl] 6,9,12,15,18 pentaoxo 1,2 dit … Wikipedia
Nelivaptan — Systematic (IUPAC) name (2S,4R) 1 [(3R) 5 chloro 1 (2,4 dimethoxyphenyl)sulfonyl 3 (2 methoxyphenyl) 2 oxo indolin 3 yl] 4 hydroxy N,N dimethyl pyrrolidine 2 carboxamide … Wikipedia

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Mozavaptan

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Mozavaptan

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