- Trichlormethiazide
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Trichlormethiazide Systematic (IUPAC) name 6-Chloro-3-(dichloromethyl)-1,1-dioxo-
3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-
7-sulfonamideClinical data AHFS/Drugs.com Micromedex Detailed Consumer Information Pregnancy cat. B (D if used to treat pregnancy-induced hypertension) Legal status ℞ Prescription only Routes Oral (capsules, tablets, oral solution) Pharmacokinetic data Bioavailability Variably absorbed from GI tract Excretion Primarily excreted unchanged in urine Identifiers CAS number 133-67-5 ATC code C03AA03 PubChem CID 5560 DrugBank DB01021 ChemSpider 5359 UNII Q58C92TUN0 KEGG D00658 ChEMBL CHEMBL1054 Chemical data Formula C8H8Cl3N3O4S2 Mol. mass 380.6558 g/mol (what is this?) (verify)
Trichlormethiazide (INN, currently being sold under the brand names of Achletin, Diu-Hydrin and Triflumen) is a diuretic with properties similar to those of hydrochlorothiazide.[1] It is usually administered for the treatment of oedema (including that which is associated with heart failure, hepatic cirrhosis and corticosteroid therapy) and hypertension.[1] In veterinary medicine, trichlormethiazide can be combined with dexamethasone to be used on horses with mild swelling of distal limbs and general bruising.[2]
Pharmacology
As a diuretic (in particular a thiazide), trichlormethiazide encourages water loss from the body.[1] Trichlormethiazide works by inhibiting Na+/Cl- ion reabsorption from the distal tubules of the kidneys.[1] In addition, Trichlormethiazide increases the excretion of potassium.[1]
Mechanism
Trichlormethiazide appears to block the active reabsorption of chloride and possibly sodium in the ascending loop of Henle. This results in excretion of sodium, chloride and water, and thus acts as a diuretic.[1] Although trichlormethiazide is used to treat hypertension, its hypotensive effects may not necessarily be due to its role as a diuretic.[1] Thiazides in general cause vasodilation by activating calcium-activated potassium channels in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.[1]
References
- ^ a b c d e f g h "DrugBank: DB01021 (Trichlormethiazide)". DrugBank. http://redpoll.pharmacy.ualberta.ca/drugbank/cgi-bin/getCard.cgi?CARD=APRD00031.txt. Retrieved 2008-01-23.
- ^ "Trichlormethiazide and Dexamethasone for veterinary use". Wedgewood Pharmacy. http://www.wedgewoodpharmacy.com/monographs/trichlormethiazide.asp. Retrieved 2008-01-24.
Antihypertensives: diuretics (C03) Sulfonamides
(except EA)Hydrochlorothiazide# • Bendroflumethiazide • Hydroflumethiazide • Chlorothiazide • Polythiazide • Trichlormethiazide • Cyclopenthiazide • Methyclothiazide • Cyclothiazide • MebutizideQuinethazone • Clopamide • Chlortalidone • Mefruside • Clofenamide • Metolazone • Meticrane • Xipamide • Indapamide • Clorexolone • FenquizonePotassium-sparing (at CD) ESC blockersOsmotic diuretics (PT, DL) VAs (DCT and CD) Other Categories:- Thiazides
- Diuretics
- Benzothiadiazines
- Sulfonamides
- Organochlorides
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