- Torasemide
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Torasemide Systematic (IUPAC) name N-[(isopropylamino)carbonyl]-4-[(3-methylphenyl)amino]pyridine-3-sulfonamide Clinical data AHFS/Drugs.com International Drug Names MedlinePlus a601212 Pregnancy cat. C(US) Legal status ℞-only (US) Routes Oral, IV Pharmacokinetic data Bioavailability 80-90% Protein binding Highly bound (>99%). Metabolism Hepatic (80%) Half-life 3.5 hours; Cirrhosis: 7-8 hours Identifiers CAS number 56211-40-6 ATC code C03CA04 PubChem CID 41781 DrugBank APRD00217 ChemSpider 38123 UNII W31X2H97FB KEGG D00382 ChEMBL CHEMBL1148 Chemical data Formula C16H20N4O3S Mol. mass 348.421 g/mol SMILES eMolecules & PubChem (what is this?) (verify) Torasemide (rINN) or torsemide (USAN) is a pyridine-sulfonyl urea type loop diuretic mainly used in the management of edema associated with congestive heart failure. It is also used at low doses for the management of hypertension. It is marketed under the brand name Demadex and Diuver.
Compared to other loop diuretics, torasemide has a more prolonged diuretic effect than equipotent doses of furosemide and relatively decreased potassium-loss. There is no evidence of torasemide-induced ototoxicity demonstrated in humans [1].
References
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External links
- Medlineplus drug information: Torsemide (Systemic) – information from USP DI Advice for the Patient
Antihypertensives: diuretics (C03) Sulfonamides
(except EA)CA inhibitors (at PT)Thiazide-likes (primarily DCT)Quinethazone • Clopamide • Chlortalidone • Mefruside • Clofenamide • Metolazone • Meticrane • Xipamide • Indapamide • Clorexolone • FenquizonePotassium-sparing (at CD) ESC blockersOsmotic diuretics (PT, DL) VAs (DCT and CD) vaptans: Conivaptan • Mozavaptan • Satavaptan • Tolvaptan
tetracyclines: DemeclocyclineOther This drug article relating to the cardiovascular system is a stub. You can help Wikipedia by expanding it.