Bendroflumethiazide Systematic (IUPAC) name 3-benzyl-1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4- benzothiadiazine-7-sulfonamide Clinical data AHFS/Drugs.com Pregnancy cat. Risk neonatal thrombocytopenia in 3rd trimester Legal status POM (UK) Routes Oral Pharmacokinetic data Bioavailability 100% Protein binding 96% Metabolism extensive Half-life 3-4 hours Identifiers CAS number ATC code C03 PubChem DrugBank ChemSpider UNII KEGG ChEBI ChEMBL Chemical data Formula C15H14F3N3O4S2 Mol. mass 421.415 g/mol SMILES & (what is this?)
It is also a fairly cheap drug, made cheap through mass production. Normal pharmaceutical trade prices vary from £0.10 - £0.20 for a 28 calendar pack of Bendroflumethiazide 2.5 tablets. Bendroflumethiazide (bendrofluazide) is a thiazide diuretic which works by inhibiting sodium absorption at the beginning of the distal convoluted tubule (DCT). Potassium is lost as a result of more sodium reaching the collecting ducts. Bendroflumethiazide has a role in the treatment of mild heart failure although loop diuretics are better for reducing overload. The main use of bendroflumethiazide currently is in hypertension (part of the effect is due to vasodilation).
Common adverse effects
- postural hypotension
- hyponatraemia, hypokalaemia, hypercalcaemia
- impaired glucose tolerance
Rare adverse effects
Symporter inhibitors Sodium chloride Sodium, potassium, chloride Antihypertensives: diuretics (C03) Sulfonamides
(except EA)CA inhibitors (at PT)Thiazide-likes (primarily DCT)
Potassium-sparing (at CD)ESC blockers Osmotic diuretics (PT, DL) VAs (DCT and CD) Other
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