- Proximal tubule
Name = Proximal Convoluted Tubule
Latin = tubulus contortus proximalis
GraySubject = 253
GrayPage = 1223
Caption = Scheme of renal tubule and its vascular supply. (1st convoluted tubule labeled at center top.)
Caption2 = 1
Glomerulus, 2 proximal tubule, 3 distal tubule
DorlandsPre = t_22
DorlandsSuf = 12830072
The proximal tubule is the portion of the duct system of the
nephronleading from Bowman's capsuleto the loop of Henle.
tructure and appearance
The most distinctive characteristic of the proximal tubule is its
brush border(or "striated border").
Brush border cell
The luminal surface of the
epithelialcells of this segment of the nephron is covered with densely packed microvilliforming a border readily visible under the light microscope. The microvilli greatly increase the luminalsurface area of the cells, presumably facilitating their resorptivefunction. The infolded membranes forming the microvilli are the site of numerous sodium pumps.
cytoplasmof the cells is densely packed with mitochondria, which are largely found in the basal region within the infoldings of the basal plasma membrane. The high quantity of mitochondria gives the cells an acidophilic appearance. The mitochondria are needed in order to supply the energy for the active transport of sodium ions out of the proximal tubule. Water passively follows the sodium out of the cell along its concentration gradient.
Cuboidal epithelial cells lining the proximal tubule have extensive lateral interdigitations between neighboring cells, which lend an appearance of having no discrete cell margins when viewed with a light microscope.
Agonalresorption of the contents of the proximal tubular contents after interruption of circulation in the capillariessurrounding the tubule often leads to disturbance of the cellular morphology of the proximal tubule cells, including the ejection of cell nuclei into the tubule lumen.
This has led some observers to describe the lumen of proximal tubules as occluded or "dirty looking", in contrast to the "clean" appearance of
distal tubules, which have quite different properties.
The proximal tubule as a part of the nephron can be divided into two sections, pars convoluta and pars recta. Differences in cell outlines exist between these segments, and therefore presumably in function too.
ultrastructure, it can be divided into three segments, S1, S2 and S3:
"'The "Pars convoluta" is the initial "convoluted portion".
"'In relation to the morphology of the kidney as a whole, the convoluted segments of the proximal tubules are confined entirely to the
Some investigators on the basis of particular functional differences have divided the convoluted part into two segments designated "S1" and "S2".
The "Pars recta" is the following "straight (descending) portion".
Straight segments descend into the outer
medulla. They terminate at a remarkably uniform level and it is their line of termination that establishes the boundary between the inner and outer stripes of the outer zone of the renal medulla.
As a logical extension of the nomenclature described above, this segment is sometimes designated as "S3".
The proximal tubule regulates the pH of the filtrate by exchanging hydrogen ions in the interstitium for bicarbonate ions in the filtrate; furthermore, it is responsible for secreting organic acids, such as creatinine and other bases, into the filtrate.
Fluid in the filtrate entering the proximal convoluted tubule is reabsorbed into the
peritubular capillaries. This is driven by sodium transport from the lumen into the blood by the Na+/K+ ATPase in the basolateral membraneof the epithelial cells. Sodium reabsorption is primarily driven by this antiporter. This is the most important transport mechanism in the PCT.
Many types of
medicationare secreted in the proximal tubule. "Further reading: Table of medication secreted in kidney"
Pathophysiology in kidney disease
Proximal tubular epithelial cells (PTECs) have a pivotal role in kidney disease.
Acute tubular necrosisoccurs when PTECs are directly damaged by toxins such as antibiotics (e.g. gentamicin), pigments (e.g. myoglobinand sepsis (e.g. mediated by lipopolysaccharidefrom gram negative bacteria). Renal tubular acidosis(proximal type) (Fanconi syndrome) occurs when the PTECs are unable to properly reabsorb glomerular filtrate so that there is increased loss of bicarbonate, glucose, amino acidsand phosphate.
PTECs also participate in the progression of tubulointerstitial injury due to
glomerulonephritis, ischemia, interstitial nephritis, vascular injury and diabetic nephropathy. In these situations PTECs may be directly affected by protein (e.g. proteinuria in glomerulonephritis), glucose(in diabetes mellitus), or cytokines (e.g. interferon-γand tumor necrosis factors). There are several ways in which PTECs may respond - by producing cytokines, chemokinesand collagen; undergoing epithelial mesenchymal transdifferentiation; necrosis or apoptosis.
* - "Mammal, kidney cortex (LM, Medium)"
* - "The Nephron: Proximal Tubule, Pars Convoluta & Pars Recta"
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