Indapamide

Indapamide
Indapamide
Systematic (IUPAC) name
4-chloro-N-(2-methyl-2,3-dihydroindol-1-yl)- 3-sulfamoyl-benzamide
Clinical data
AHFS/Drugs.com monograph
MedlinePlus a684062
Pregnancy cat.  ?
Legal status POM
Routes Oral tablet
Pharmacokinetic data
Protein binding 71-79%
Metabolism Hepatic
Half-life 14-18 hours
Identifiers
CAS number 26807-65-8 YesY
ATC code C03BA11
PubChem CID 3702
DrugBank APRD01031
ChemSpider 3574 YesY
UNII F089I0511L YesY
KEGG D00345 YesY
ChEMBL CHEMBL406 YesY
Chemical data
Formula C16H16ClN3O3S 
Mol. mass 365.835 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Indapamide is a non-thiazide sulphonamide diuretic drug marketed by Servier, generally used in the treatment of hypertension, as well as decompensated cardiac failure. The US trade name for indapamide is Lozol.[1] Indapamide is marketed as Natrilix outside of the US, as Insig in Australia. Combination preparations with perindopril (an ACE inhibitor antihypertensive) are also available.

It is described as a thiazide-like diuretic.[2]

Contents

Form and composition

Indapamide is available generically as 1.25 mg and 2.5 mg non-scored tablets.[3]

Indications

Hypertension and edema due to congestive heart failure. Indapamide has been proven in the HYVET trial to reduce stroke and all cause mortality when given with or without perindopril to people over the age of 80 for the treatment of hypertension.

Dosage and administration

The adult dosage is 1.25 to 5 mg by orally once daily usually in the morning.

Contraindications

Indapamide is contraindicated in known hypersensitivity to sulfonamides, severe renal failure, hepatic encephalopathy or severe hepatic failure and hypokalemia (low blood potassium levels).

There is insufficient safety data to recommend indapamide use in pregnancy or breastfeeding.

Interactions

Caution is advised in the combination of indapamide with lithium and nonantiarrhythmic drugs causing wave burst arrhythmia (astemizole, bepridil, IV erythromycin, halofantrine, pentamidine, sultopride, terfenadine, vincamine).

Precautions

Monitoring of potassium and uric acid serum levels is recommended, especially in subjects with a predisposition or a sensitivity to hypokalemia and in patients with gout.

Adverse effects

Commonly reported adverse events are hypokalemia (low potassium levels), fatigue, orthostatic hypotension (blood pressure decrease on standing up) and allergic manifestations.

Overdosage

Symptoms of overdosage would be those associated with a diuretic effect: electrolyte disturbances, hypotension, and muscular weakness. Treatment should be symptomatic, directed at correcting the electrolyte abnormalities.

References


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  • Diuretic — This illustration shows where some types of diuretics act, and what they do. A diuretic provides a means of forced diuresis which elevates the rate of urination. There are several categories of diuretics. All diuretics increase the excretion of… …   Wikipedia

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