Clopamide

Clopamide
Clopamide
Systematic (IUPAC) name
4-chloro-N-(2,6-dimethyl-1-piperidyl)-3-sulfamoyl-
benzamide
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 636-54-4
ATC code C03BA03
PubChem CID 2804
ChemSpider 2702 YesY
UNII 17S83WON0I YesY
KEGG D02460 YesY
Chemical data
Formula C14H20ClN3O3S 
Mol. mass 345.846 g/mol
SMILES eMolecules & PubChem
 YesY(what is this?)  (verify)

Clopamide is a piperidine diuretic.

Mechanism of Action of Clopamide: Clopamide is categorised as a thiazide like drug and works in similar way as the thiazide diuretics do. It acts at the Proximal Convoluted tubule site of the nephron where it inhibits the sodium-chloride cotransporter. Clopamide selectively binds at the chloride binding site of the sodium chloride cotransporter in the PCT cells on the luminal side and thus intereferes with the reabsorption of NaCl and thus causing an equiosmolar excretion of water along with NaCl.