- Clopamide
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Clopamide Systematic (IUPAC) name 4-chloro-N-(2,6-dimethyl-1-piperidyl)-3-sulfamoyl-
benzamideClinical data AHFS/Drugs.com International Drug Names Pregnancy cat. ? Legal status ? Identifiers CAS number 636-54-4 ATC code C03BA03 PubChem CID 2804 ChemSpider 2702 UNII 17S83WON0I KEGG D02460 Chemical data Formula C14H20ClN3O3S Mol. mass 345.846 g/mol SMILES eMolecules & PubChem (what is this?) (verify) Clopamide is a piperidine diuretic.
Mechanism of Action of Clopamide: Clopamide is categorised as a thiazide like drug and works in similar way as the thiazide diuretics do. It acts at the Proximal Convoluted tubule site of the nephron where it inhibits the sodium-chloride cotransporter. Clopamide selectively binds at the chloride binding site of the sodium chloride cotransporter in the PCT cells on the luminal side and thus intereferes with the reabsorption of NaCl and thus causing an equiosmolar excretion of water along with NaCl.
Antihypertensives: diuretics (C03) Sulfonamides
(except EA)CA inhibitors (at PT)Thiazide-likes (primarily DCT)Quinethazone • Clopamide • Chlortalidone • Mefruside • Clofenamide • Metolazone • Meticrane • Xipamide • Indapamide • Clorexolone • FenquizonePotassium-sparing (at CD) ESC blockersOsmotic diuretics (PT, DL) VAs (DCT and CD) vaptans: Conivaptan • Mozavaptan • Satavaptan • Tolvaptan
tetracyclines: DemeclocyclineOther #WHO-EM. ‡Withdrawn from market. Clinical trials: †Phase III. §Never to phase III This drug article relating to the cardiovascular system is a stub. You can help Wikipedia by expanding it.