Melanocortin 5 receptor

Melanocortin 5 receptor
Identifiers
Symbols	MC5R;
External IDs	OMIM: 600042 MGI: 99420 HomoloGene: 4321 GeneCards: MC5R Gene
Gene Ontology Molecular function • receptor activity • G-protein coupled receptor activity • melanocortin receptor activity • protein binding • hormone binding Cellular component • plasma membrane • plasma membrane • integral to plasma membrane Biological process • G-protein signaling, coupled to cyclic nucleotide second messenger • positive regulation of cAMP biosynthetic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4161	17203
Ensembl	ENSG00000176136	ENSMUSG00000007480
UniProt	P33032	Q496T0
RefSeq (mRNA)	NM_005913	NM_013596.2
RefSeq (protein)	NP_005904	NP_038624.2
Location (UCSC)	Chr 18: 13.83 – 13.83 Mb	Chr 18: 68.5 – 68.5 Mb
PubMed search	[1]	[2]

Melanocortin receptor 5 is a protein that in humans is encoded by the MC5R gene.^[1][2] It is located on the chromosome 18 in the human genome.^[2] When the melanocortin 5 receptor was disrupted in transgenic mice, it induced disruption of their exocrine glands and resulted in decreased production of sebum.^[3]

See also

• Melanocortin receptor

References

1. ^ Chhajlani V, Muceniece R, Wikberg JE (Oct 1993). "Molecular cloning of a novel human melanocortin receptor". Biochem Biophys Res Commun 195 (2): 866–73. doi:10.1006/bbrc.1993.2125. PMID 8396929. 
2. ^ ^{a b} "Entrez Gene: MC5R melanocortin 5 receptor". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4161. 
3. ^ Thiboutot, Diane; Sivarajah, Aruntha; Gilliland, Kathryn ; Cong, Zhaoyuan; Clawson, Gary (2000). "The Melanocortin 5 Receptor is Expressed in Human Sebaceous Glands and Rat Preputial Cells". Journal of Investigative Dermatology 115 (4): 614–619. doi:10.1046/j.1523-1747.2000.00094.x. PMID 10998132. http://www.nature.com/jid/journal/v115/n4/abs/5600836a.html. Retrieved 2008-01-04. 

External links

• "Melanocortin Receptors: MC₅". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2356. 

Further reading

• Fathi Z, Iben LG, Parker EM (1995). "Cloning, expression, and tissue distribution of a fifth melanocortin receptor subtype.". Neurochem. Res. 20 (1): 107–13. doi:10.1007/BF00995160. PMID 7739752. 
• Chowdhary BP, Gustavsson I, Wikberg JE, Chhajlani V (1994). "Localization of the human melanocortin-5 receptor gene (MC5R) to chromosome band 18p11.2 by fluorescence in situ hybridization.". Cytogenet. Cell Genet. 68 (1–2): 79–81. doi:10.1159/000133895. PMID 7956366. 
• Griffon N, Mignon V, Facchinetti P, et al. (1994). "Molecular cloning and characterization of the rat fifth melanocortin receptor". Biochem. Biophys. Res. Commun. 200 (2): 1007–14. doi:10.1006/bbrc.1994.1550. PMID 8179577. 
• Gantz I, Shimoto Y, Konda Y, et al. (1994). "Molecular cloning, expression, and characterization of a fifth melanocortin receptor". Biochem. Biophys. Res. Commun. 200 (3): 1214–20. doi:10.1006/bbrc.1994.1580. PMID 8185570. 
• Chhajlani V (1997). "Distribution of cDNA for melanocortin receptor subtypes in human tissues". Biochem. Mol. Biol. Int. 38 (1): 73–80. PMID 8932521. 
• Yang YK, Ollmann MM, Wilson BD, et al. (1997). "Effects of recombinant agouti-signaling protein on melanocortin action". Mol. Endocrinol. 11 (3): 274–80. doi:10.1210/me.11.3.274. PMID 9058374. 
• Frändberg PA, Xu X, Chhajlani V (1997). "Glutamine235 and arginine272 in human melanocortin 5 receptor determines its low affinity to MSH". Biochem. Biophys. Res. Commun. 236 (2): 489–92. doi:10.1006/bbrc.1997.6994. PMID 9240466. 
• Yang YK, Thompson DA, Dickinson CJ, et al. (1999). "Characterization of Agouti-related protein binding to melanocortin receptors". Mol. Endocrinol. 13 (1): 148–55. doi:10.1210/me.13.1.148. PMID 9892020. 
• Hatta N, Dixon C, Ray AJ, et al. (2001). "Expression, candidate gene, and population studies of the melanocortin 5 receptor". J. Invest. Dermatol. 116 (4): 564–70. doi:10.1046/j.0022-202x.2001.01286.x. PMID 11286624. 
• Bednarek MA, MacNeil T, Kalyani RN, et al. (2001). "Selective, high affinity peptide antagonists of alpha-melanotropin action at human melanocortin receptor 4: their synthesis and biological evaluation in vitro". J. Med. Chem. 44 (22): 3665–72. doi:10.1021/jm010165y. PMID 11606131. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Lapinsh M, Veiksina S, Uhlén S, et al. (2005). "Proteochemometric mapping of the interaction of organic compounds with melanocortin receptor subtypes". Mol. Pharmacol. 67 (1): 50–9. doi:10.1124/mol.104.002857. PMID 15470082. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Lohoff FW, Berrettini WH (2006). "Lack of association between variations in the melanocortin 5 receptor gene and bipolar disorder". Psychiatr. Genet. 15 (4): 255–8. doi:10.1097/00041444-200512000-00007. PMID 16314755. 
• Grieco P, Cai M, Han G, et al. (2007). "Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5". Peptides 28 (6): 1191–6. doi:10.1016/j.peptides.2007.02.012. PMC 1955225. PMID 17482720. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1955225. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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