- TAS2R16
TAS2R16 (
taste receptor , type 2, member 16) is ahuman gene that encodes for a receptor that may play a role in the perception ofbitterness . [cite journal | author=Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W | title=The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides | journal=Nat Genet | year=2002 | pages=397–401 | volume=32 | issue=3 | pmid=12379855 | doi=10.1038/ng1014] [cite journal | author=Drewnowski A | title=The science and complexity of bitter taste | journal=Nutr Rev | year=2001 | pages=163–9 | volume=59 | issue=6 | pmid=11444592]Variants of this gene have been linked to an increased risk for
alcohol dependence .cite journal |author=Hinrichs AL, Wang JC, Bufe B, "et al" |title=Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence |journal=Am. J. Hum. Genet. |volume=78 |issue=1 |pages=103–11 |year=2006 |pmid=16385453 |doi=10.1086/499253]The TAS2R16 gene is located on the long (q) arm of chromosome 7 at position 31.1 - 31.3, from
base pair 122,228,764 to base pair 122,229,639.ee also
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Taste receptor References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Kinnamon SC |title=A plethora of taste receptors. |journal=Neuron |volume=25 |issue= 3 |pages= 507–10 |year= 2000 |pmid= 10774719 |doi=
*cite journal | author=Margolskee RF |title=Molecular mechanisms of bitter and sweet taste transduction. |journal=J. Biol. Chem. |volume=277 |issue= 1 |pages= 1–4 |year= 2002 |pmid= 11696554 |doi= 10.1074/jbc.R100054200
*cite journal | author=Montmayeur JP, Matsunami H |title=Receptors for bitter and sweet taste. |journal=Curr. Opin. Neurobiol. |volume=12 |issue= 4 |pages= 366–71 |year= 2002 |pmid= 12139982 |doi=
*cite journal | author=Adler E, Hoon MA, Mueller KL, "et al." |title=A novel family of mammalian taste receptors. |journal=Cell |volume=100 |issue= 6 |pages= 693–702 |year= 2000 |pmid= 10761934 |doi=
*cite journal | author=Chandrashekar J, Mueller KL, Hoon MA, "et al." |title=T2Rs function as bitter taste receptors. |journal=Cell |volume=100 |issue= 6 |pages= 703–11 |year= 2000 |pmid= 10761935 |doi=
*cite journal | author=Firestein S |title=The good taste of genomics. |journal=Nature |volume=404 |issue= 6778 |pages= 552–3 |year= 2000 |pmid= 10766221 |doi= 10.1038/35007167
*cite journal | author=Matsunami H, Montmayeur JP, Buck LB |title=A family of candidate taste receptors in human and mouse. |journal=Nature |volume=404 |issue= 6778 |pages= 601–4 |year= 2000 |pmid= 10766242 |doi= 10.1038/35007072
*cite journal | author=Bufe B, Hofmann T, Krautwurst D, "et al." |title=The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. |journal=Nat. Genet. |volume=32 |issue= 3 |pages= 397–401 |year= 2002 |pmid= 12379855 |doi= 10.1038/ng1014
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Zhang Y, Hoon MA, Chandrashekar J, "et al." |title=Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. |journal=Cell |volume=112 |issue= 3 |pages= 293–301 |year= 2003 |pmid= 12581520 |doi=
*cite journal | author=Hillier LW, Fulton RS, Fulton LA, "et al." |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Fischer A, Gilad Y, Man O, Pääbo S |title=Evolution of bitter taste receptors in humans and apes. |journal=Mol. Biol. Evol. |volume=22 |issue= 3 |pages= 432–6 |year= 2005 |pmid= 15496549 |doi= 10.1093/molbev/msi027
*cite journal | author=Go Y, Satta Y, Takenaka O, Takahata N |title=Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates. |journal=Genetics |volume=170 |issue= 1 |pages= 313–26 |year= 2006 |pmid= 15744053 |doi= 10.1534/genetics.104.037523
*cite journal | author=Mueller KL, Hoon MA, Erlenbach I, "et al." |title=The receptors and coding logic for bitter taste. |journal=Nature |volume=434 |issue= 7030 |pages= 225–9 |year= 2005 |pmid= 15759003 |doi= 10.1038/nature03352
*cite journal | author=Hinrichs AL, Wang JC, Bufe B, "et al." |title=Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence. |journal=Am. J. Hum. Genet. |volume=78 |issue= 1 |pages= 103–11 |year= 2006 |pmid= 16385453 |doi= 10.1086/499253
*cite journal | author=Behrens M, Bartelt J, Reichling C, "et al." |title=Members of RTP and REEP gene families influence functional bitter taste receptor expression. |journal=J. Biol. Chem. |volume=281 |issue= 29 |pages= 20650–9 |year= 2006 |pmid= 16720576 |doi= 10.1074/jbc.M513637200External links
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