- SCGB2A2
protein
Name=secretoglobin, family 2A, member 2
caption=
width=
HGNCid=70501
Symbol=TAS2R16
AltSymbols=
EntrezGene=42502
OMIM=604867
RefSeq=
UniProt=Q132963
PDB=
ECnumber=
Chromosome=11
Arm=q
Band=12.3
LocusSupplementaryData=-q13.1SCGB2A2 is a gene located on chromosome 11, at locus 11q13. It codes a protein named « secretoglobin, family 2A, member 2 », according to the official international nomenclature. Other names for the protein are : mammaglobin (MGB, MAM)cite journal | first=MA | last=Watson | coauthors= Fleming TP. | title= Mammaglobin, a mammary-specific member of the uteroglobin gene family, is overexpressed in human breast cancer | journal=
Cancer Research | year=1996 | volume=56 |pages=860 – 865|pmid=8631025] , mammaglobin-1 (MGB1), precursor of mammaglobin-A (MGBA), uteroglobin 2 (UGB2).SCGB2A2 is member of the superfamily of secretoglobins, a group of small dimeric secreted and sometimes glycosylated proteins. Expressed mainly in mucosa, secretoglobins seems to be involved in cell signalling, immune response, chemotaxis, and could also serve as transporters for steroid hormones in humanscite journal | first=J | last= Klug | coauthors= Beier HM, Bernard A, Chilton BS, Fleming TP, Lehrer RI, Miele L, Pattabiraman N, Singh G. | title= Uteroglobin/Clara cell 10-kDa family of proteins: nomenclature committee report | journal=Annals of the New York Academy of Sciences | year=2000 | volume=923 |pages=348 – 354| pmid=11193777] cite journal | first=NM | last= Brown | coauthors= Stenzel TT, Friedman PN, Henslee J, Huper G, Marks JR. | title= Evaluation of expression based markers for the detection of breast cancer cells | journal=Breast Cancer Research and Treatment | year=2006 | volume=97 |pages=41 – 47| pmid=16319979 | doi= 10.1007/s10549-005-9085-8] .SCGB2A2 and breast cancer
SCGB2A2 expression is highly specific of mammary tissue, and is increasingly used for identification and detection of disseminated breast cancer cellscite journal | first=M | last= Lacroix | coauthors= | title= Significance, detection and markers of disseminated breast cancer cells | journal=
Endocrine-Related Cancer | year=2006 | volume=13 |pages=1033 – 1067| pmid=17158753| doi= 10.1677/ERC-06-0001] .References
External links
*
*
Wikimedia Foundation. 2010.
