Mammaglobin-A

Mammaglobin-A
Secretoglobin, family 2A, member 2
Identifiers
Symbols SCGB2A2; MGB1; MGC71974; UGB2
External IDs OMIM605562 HomoloGene105651 GeneCards: SCGB2A2 Gene
RNA expression pattern
PBB GE SCGB2A2 206378 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4250 n/a
Ensembl ENSG00000110484 n/a
UniProt Q13296 n/a
RefSeq (mRNA) NM_002411 n/a
RefSeq (protein) NP_002402 n/a
Location (UCSC) Chr 11:
62.04 – 62.04 Mb
n/a
PubMed search [1] n/a

Mammaglobin-A also known as secretoglobin family 2A member 2 is a protein that in humans is encoded by the SCGB2A2 gene.[1][2][3]

Contents

Function

SCGB2A2 is member of the superfamily of secretoglobins, a group of small dimeric secreted and sometimes glycosylated proteins. Expressed mainly in mucosa, secretoglobins seems to be involved in cell signalling, immune response, chemotaxis, and could also serve as transporters for steroid hormones in humans.[4][5]

Clinical significance

SCGB2A2 expression is highly specific of mammary tissue, and is increasingly used for identification and detection of disseminated breast cancer cells.[6]

References

  1. ^ Watson MA, Darrow C, Zimonjic DB, Popescu NC, Fleming TP (Mar 1998). "Structure and transcriptional regulation of the human mammaglobin gene, a breast cancer associated member of the uteroglobin gene family localized to chromosome 11q13". Oncogene 16 (6): 817–24. doi:10.1038/sj.onc.1201597. PMID 9488047. 
  2. ^ Watson MA, Fleming TP (Jul 1996). "Mammaglobin, a mammary-specific member of the uteroglobin gene family, is overexpressed in human breast cancer". Cancer Res 56 (4): 860–5. PMID 8631025. 
  3. ^ "Entrez Gene: SCGB2A2 secretoglobin, family 2A, member 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4250. 
  4. ^ Klug, J; Beier HM, Bernard A, Chilton BS, Fleming TP, Lehrer RI, Miele L, Pattabiraman N, Singh G. (2000). "Uteroglobin/Clara cell 10-kDa family of proteins: nomenclature committee report". Annals of the New York Academy of Sciences 923: 348–354. doi:10.1111/j.1749-6632.2000.tb05549.x. PMID 11193777. 
  5. ^ Brown, NM; Stenzel TT, Friedman PN, Henslee J, Huper G, Marks JR. (2006). "Evaluation of expression based markers for the detection of breast cancer cells". Breast Cancer Research and Treatment 97 (1): 41–47. doi:10.1007/s10549-005-9085-8. PMID 16319979. 
  6. ^ Lacroix, M (2006). "Significance, detection and markers of disseminated breast cancer cells". Endocrine-Related Cancer 13 (4): 1033–1067. doi:10.1677/ERC-06-0001. PMID 17158753. 

Further reading



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  • SCGB2A2 (gène) — SCGB2A2 SCGB2A2 est un gène localisé sur le chromosome 11, au locus 11q13. Il code une protéine appelée « secrétoglobine, famille 2A, membre 2 », conformément à la nomenclature internationale officielle. D autres noms pour cette… …   Wikipédia en Français

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