Mammaglobin-B

Secretoglobin, family 2A, member 1
Identifiers
Symbols	SCGB2A1; LPHC; MGB2; MGC71973; UGB3
External IDs	OMIM: 604398 HomoloGene: 88664 GeneCards: SCGB2A1 Gene
Gene Ontology Molecular function • binding • androgen binding Cellular component • cellular_component • extracellular region Biological process • biological_process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4246	n/a
Ensembl	ENSG00000124939	n/a
UniProt	O75556	n/a
RefSeq (mRNA)	NM_002407	n/a
RefSeq (protein)	NP_002398	n/a
Location (UCSC)	Chr 11: 61.98 – 61.98 Mb	n/a
PubMed search	[1]	n/a

Mammaglobin-B also known as secretoglobin family 2A member 1 is a protein that in humans is encoded by the SCGB2A1 gene.^[1][2]

SCGB2A1 and breast cancer

SCGB2A1 expression is highly specific of mammary tissue, and has been used for identification and detection of disseminated breast cancer cells^[3].

References

1. ^ Becker RM, Darrow C, Zimonjic DB, Popescu NC, Watson MA, Fleming TP (Jan 1999). "Identification of mammaglobin B, a novel member of the uteroglobin gene family". Genomics 54 (1): 70–8. doi:10.1006/geno.1998.5539. PMID 9806831. 
2. ^ "Entrez Gene: SCGB2A1 secretoglobin, family 2A, member 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4246. 
3. ^ Lacroix, M (2006). "Significance, detection and markers of disseminated breast cancer cells". Endocrine-Related Cancer 13 (4): 1033–1067. doi:10.1677/ERC-06-0001. PMID 17158753. 

Further reading

• Molloy MP, Bolis S, Herbert BR, et al. (1998). "Establishment of the human reflex tear two-dimensional polyacrylamide gel electrophoresis reference map: new proteins of potential diagnostic value.". Electrophoresis 18 (15): 2811–5. doi:10.1002/elps.1150181516. PMID 9504814. 
• Lehrer RI, Xu G, Abduragimov A, et al. (1998). "Lipophilin, a novel heterodimeric protein of human tears.". FEBS Lett. 432 (3): 163–7. doi:10.1016/S0014-5793(98)00852-7. PMID 9720917. 
• Zhao C, Nguyen T, Yusifov T, et al. (1999). "Lipophilins: human peptides homologous to rat prostatein.". Biochem. Biophys. Res. Commun. 256 (1): 147–55. doi:10.1006/bbrc.1999.0274. PMID 10066439. 
• Evans V, Vockler C, Friedlander M, et al. (2001). "Lacryglobin in human tears, a potential marker for cancer.". Clin. Experiment. Ophthalmol. 29 (3): 161–3. doi:10.1046/j.1442-9071.2001.00408.x. PMID 11446459. 
• Carter D, Douglass JF, Cornellison CD, et al. (2002). "Purification and characterization of the mammaglobin/lipophilin B complex, a promising diagnostic marker for breast cancer.". Biochemistry 41 (21): 6714–22. doi:10.1021/bi0159884. PMID 12022875. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages.". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042. 
• Sjödin A, Guo D, Sørhaug S, et al. (2003). "Dysregulated secretoglobin expression in human lung cancers.". Lung Cancer 41 (1): 49–56. doi:10.1016/S0169-5002(03)00126-0. PMID 12826312. 
• Ouellette RJ, Richard D, Maïcas E (2004). "RT-PCR for mammaglobin genes, MGB1 and MGB2, identifies breast cancer micrometastases in sentinel lymph nodes.". Am. J. Clin. Pathol. 121 (5): 637–43. doi:10.1309/MMAC-TXT5-5L8Q-TKC1. PMID 15151203. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Xiao F, Mirwald A, Papaioannou M, et al. (2006). "Secretoglobin 2A1 is under selective androgen control mediated by a peculiar binding site for Sp family transcription factors.". Mol. Endocrinol. 19 (12): 2964–78. doi:10.1210/me.2004-0408. PMID 16020486. 
• Bernstein JL, Godbold JH, Raptis G, et al. (2005). "Identification of mammaglobin as a novel serum marker for breast cancer.". Clin. Cancer Res. 11 (18): 6528–35. doi:10.1158/1078-0432.CCR-05-0415. PMID 16166429.