SCGB1D2

Secretoglobin, family 1D, member 2, also known as SCGB1D2, is a human gene.cite web | title = Entrez Gene: SCGB1D2 secretoglobin, family 1D, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10647| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the lipophilin subfamily, part of the uteroglobin superfamily, and is an ortholog of prostatein, the major secretory glycoprotein of the rat ventral prostate gland. Lipophilin gene products are widely expressed in normal tissues, especially in endocrine-responsive organs. Assuming that human lipophilins are the functional counterparts of prostatein, they may be transcriptionally regulated by steroid hormones, with the ability to bind androgens, other steroids and possibly bind and concentrate estramustine, a chemotherapeutic agent widely used for prostate cancer. Although the gene has been reported to be on chromosome 10, this sequence appears to be from a cluster of genes on chromosome 11 that includes mammaglobin 2.cite web | title = Entrez Gene: SCGB1D2 secretoglobin, family 1D, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10647| accessdate = ]

SCGB1D2 expression is high in mammary tissue, and is sometimes used for identification and detection of disseminated breast cancer cellscite journal | first=M | last= Lacroix | coauthors= | title= Significance, detection and markers of disseminated breast cancer cells | journal= Endocrine-Related Cancer | year=2006 | volume=13 |pages=1033 – 1067| pmid=17158753| doi= 10.1677/ERC-06-0001] .

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Culleton J, O'Brien N, Ryan BM, "et al." |title=Lipophilin B: A gene preferentially expressed in breast tissue and upregulated in breast cancer. |journal=Int. J. Cancer |volume=120 |issue= 5 |pages= 1087–92 |year= 2007 |pmid= 17163411 |doi= 10.1002/ijc.22471
*cite journal | author=Sjödin A, Guo D, Lund-Johansen M, "et al." |title=Secretoglobins in the human pituitary: high expression of lipophilin B and its down-regulation in pituitary adenomas. |journal=Acta Neuropathol. |volume=109 |issue= 4 |pages= 381–6 |year= 2005 |pmid= 15668787 |doi= 10.1007/s00401-004-0972-6
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Carter D, Dillon DC, Reynolds LD, "et al." |title=Serum antibodies to lipophilin B detected in late stage breast cancer patients. |journal=Clin. Cancer Res. |volume=9 |issue= 2 |pages= 749–54 |year= 2003 |pmid= 12576445 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Carter D, Douglass JF, Cornellison CD, "et al." |title=Purification and characterization of the mammaglobin/lipophilin B complex, a promising diagnostic marker for breast cancer. |journal=Biochemistry |volume=41 |issue= 21 |pages= 6714–22 |year= 2002 |pmid= 12022875 |doi=
*cite journal | author=Zhao C, Nguyen T, Yusifov T, "et al." |title=Lipophilins: human peptides homologous to rat prostatein. |journal=Biochem. Biophys. Res. Commun. |volume=256 |issue= 1 |pages= 147–55 |year= 1999 |pmid= 10066439 |doi= 10.1006/bbrc.1999.0274
*cite journal | author=Lehrer RI, Xu G, Abduragimov A, "et al." |title=Lipophilin, a novel heterodimeric protein of human tears. |journal=FEBS Lett. |volume=432 |issue= 3 |pages= 163–7 |year= 1998 |pmid= 9720917 |doi=

External links

* [http://www.nextbio.com/b/home/home.nb?id=40477&type=feature&name=SCGB1D2 Microarray study results where SCGB1D2 is significantly up or downregulated]

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes