FZD8

Frizzled homolog 8 (Drosophila), also known as FZD8, is a human gene.cite web | title = Entrez Gene: FZD8 frizzled homolog 8 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8325| accessdate = ]

PBB_Summary
section_title =
summary_text = This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.cite web | title = Entrez Gene: FZD8 frizzled homolog 8 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8325| accessdate = ]

ee also

* Frizzled

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Wang Y, Macke JP, Abella BS, "et al." |title=A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. |journal=J. Biol. Chem. |volume=271 |issue= 8 |pages= 4468–76 |year= 1996 |pmid= 8626800 |doi=
*cite journal | author=Finch PW, He X, Kelley MJ, "et al." |title=Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 13 |pages= 6770–5 |year= 1997 |pmid= 9192640 |doi=
*cite journal | author=Tamai K, Semenov M, Kato Y, "et al." |title=LDL-receptor-related proteins in Wnt signal transduction. |journal=Nature |volume=407 |issue= 6803 |pages= 530–5 |year= 2000 |pmid= 11029007 |doi= 10.1038/35035117
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Saitoh T, Hirai M, Katoh M |title=Molecular cloning and characterization of human Frizzled-8 gene on chromosome 10p11.2. |journal=Int. J. Oncol. |volume=18 |issue= 5 |pages= 991–6 |year= 2001 |pmid= 11295046 |doi=
*cite journal | author=Semënov MV, Tamai K, Brott BK, "et al." |title=Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6. |journal=Curr. Biol. |volume=11 |issue= 12 |pages= 951–61 |year= 2001 |pmid= 11448771 |doi=
*cite journal | author=Dann CE, Hsieh JC, Rattner A, "et al." |title=Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains. |journal=Nature |volume=412 |issue= 6842 |pages= 86–90 |year= 2001 |pmid= 11452312 |doi= 10.1038/35083601
*cite journal | author=Yao R, Maeda T, Takada S, Noda T |title=Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled. |journal=Biochem. Biophys. Res. Commun. |volume=286 |issue= 4 |pages= 771–8 |year= 2001 |pmid= 11520064 |doi= 10.1006/bbrc.2001.5430
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Deloukas P, Earthrowl ME, Grafham DV, "et al." |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462
*cite journal | author=Omoto S, Hayashi T, Kitahara K, "et al." |title=Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R). |journal=Ophthalmic Genet. |volume=25 |issue= 2 |pages= 81–90 |year= 2004 |pmid= 15370539 |doi= 10.1080/13816810490514270
*cite journal | author=Lu W, Yamamoto V, Ortega B, Baltimore D |title=Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. |journal=Cell |volume=119 |issue= 1 |pages= 97–108 |year= 2004 |pmid= 15454084 |doi= 10.1016/j.cell.2004.09.019

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