5-HT1F receptor

5-hydroxytryptamine (serotonin) receptor 1F, also known as HTR1F is a 5-HT₁ receptor protein and also denotes the human gene encoding it.cite web | title = Entrez Gene: HTR1F 5-hydroxytryptamine (serotonin) receptor 1F| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3355| accessdate = ]

Ligands

Agonists

* LY-334,370cite journal | author = Wainscott DB, Krushinski JH, Audia JE, Schaus JM, Zgombick JM, Lucaites VL, Nelson DL | title = [³H] -LY-334,370, a novel radioligand for the 5-HT_1F receptor. I. In vitro characterization of binding properties | journal = Naunyn Schmiedebergs Arch. Pharmacol. | volume = 371 | issue = 3 | pages = 169–77 | year = 2005 | pmid = 15900510 | doi = 10.1007/s00210-005-1035-9 | issn = ] and related benzamidescite journal | author = Zhang D, Kohlman D, Krushinski J, Liang S, Ying BP, Reilly JE, Dinn SR, Wainscott DB, Nutter S, Gough W, Nelson DL, Schaus JM, Xu YC | title = Design, synthesis and evaluation of bicyclic benzamides as novel 5-HT_1F receptor agonists | journal = Bioorg. Med. Chem. Lett. | volume = 14 | issue = 24 | pages = 6011–6 | year = 2004 | pmid = 15546719 | doi = 10.1016/j.bmcl.2004.09.079 | issn = ]
* LY-344,864 (N- [(3R)-3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazo l-6-yl] -4-fluorobenzamide)

Antagonists

No selective 5HT_1F antagonists are available as yet.

ee also

* 5-HT₁ receptor
* 5-HT receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hoyer D, Hannon JP, Martin GR |title=Molecular, pharmacological and functional diversity of 5-HT receptors. |journal=Pharmacol. Biochem. Behav. |volume=71 |issue= 4 |pages= 533–54 |year= 2002 |pmid= 11888546 |doi=
*cite journal | author=Raymond JR, Mukhin YV, Gelasco A, "et al." |title=Multiplicity of mechanisms of serotonin receptor signal transduction. |journal=Pharmacol. Ther. |volume=92 |issue= 2-3 |pages= 179–212 |year= 2002 |pmid= 11916537 |doi=
*cite journal | author=Amlaiky N, Ramboz S, Boschert U, "et al." |title=Isolation of a mouse "5HT1E-like" serotonin receptor expressed predominantly in hippocampus. |journal=J. Biol. Chem. |volume=267 |issue= 28 |pages= 19761–4 |year= 1992 |pmid= 1328180 |doi=
*cite journal | author=Adham N, Kao HT, Schecter LE, "et al." |title=Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 2 |pages= 408–12 |year= 1993 |pmid= 8380639 |doi=
*cite journal | author=Lovenberg TW, Erlander MG, Baron BM, "et al." |title=Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 6 |pages= 2184–8 |year= 1993 |pmid= 8384716 |doi=
*cite journal | author=Maassen VanDenBrink A, Vergouwe MN, Ophoff RA, "et al." |title=Chromosomal localization of the 5-HT1F receptor gene: no evidence for involvement in response to sumatriptan in migraine patients. |journal=Am. J. Med. Genet. |volume=77 |issue= 5 |pages= 415–20 |year= 1999 |pmid= 9632173 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Bhatnagar A, Sheffler DJ, Kroeze WK, "et al." |title=Caveolin-1 interacts with 5-HT2A serotonin receptors and profoundly modulates the signaling of selected Galphaq-coupled protein receptors. |journal=J. Biol. Chem. |volume=279 |issue= 33 |pages= 34614–23 |year= 2004 |pmid= 15190056 |doi= 10.1074/jbc.M404673200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Hannula-Jouppi K, Kaminen-Ahola N, Taipale M, "et al." |title=The axon guidance receptor gene ROBO1 is a candidate gene for developmental dyslexia. |journal=PLoS Genet. |volume=1 |issue= 4 |pages= e50 |year= 2006 |pmid= 16254601 |doi= 10.1371/journal.pgen.0010050

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