5-HT5A receptor

5-hydroxytryptamine (serotonin) receptor 5A, also known as HTR5A, is a human gene.cite web | title = Entrez Gene: HTR5A 5-hydroxytryptamine (serotonin) receptor 5A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3361| accessdate = ]

PBB_Summary
section_title =
summary_text = The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member of 5-hydroxytryptamine (serotonin) receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G-proteins. This protein has been shown to function in part through the regulation of intracellular Ca2+ mobilization.cite web | title = Entrez Gene: HTR5A 5-hydroxytryptamine (serotonin) receptor 5A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3361| accessdate = ]

elective Ligands

No highly selective ligands are commercially available for the 5HT_5A receptor as yet. When selective activation of this receptor is desired in scientific research, the non-selective serotonin receptor agonist 5-Carboxamidotryptamine is used in conjunction with antagonists for its other targets (principally 5HT_1A, 5HT_1B, 5HT_1D and 5HT₇). Research in this area is ongoing. [Wesołowska A. In the search for selective ligands of 5-HT5, 5-HT6 and 5-HT7 serotonin receptors. "Polish Journal of Pharmacology". 2002 Jul-Aug;54(4):327-41. PMID 12523486]

ee also

* 5-HT receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Raymond JR, Mukhin YV, Gelasco A, "et al." |title=Multiplicity of mechanisms of serotonin receptor signal transduction. |journal=Pharmacol. Ther. |volume=92 |issue= 2-3 |pages= 179–212 |year= 2002 |pmid= 11916537 |doi=
*cite journal | author=Thomas DR |title=5-ht5A receptors as a therapeutic target. |journal=Pharmacol. Ther. |volume=111 |issue= 3 |pages= 707–14 |year= 2006 |pmid= 16516972 |doi= 10.1016/j.pharmthera.2005.12.006
*cite journal | author=Rees S, den Daas I, Foord S, "et al." |title=Cloning and characterisation of the human 5-HT5A serotonin receptor. |journal=FEBS Lett. |volume=355 |issue= 3 |pages= 242–6 |year= 1995 |pmid= 7988681 |doi=
*cite journal | author=Schanen NC, Scherer SW, Tsui LC, Francke U |title=Assignment of the 5-hydroxytryptamine (serotonin) receptor 5A gene (HTR5A) to human chromosome band 7q36.1. |journal=Cytogenet. Cell Genet. |volume=72 |issue= 2-3 |pages= 187–8 |year= 1997 |pmid= 8978771 |doi=
*cite journal | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi=
*cite journal | author=Francken BJ, Josson K, Lijnen P, "et al." |title=Human 5-hydroxytryptamine(5A) receptors activate coexpressed G(i) and G(o) proteins in Spodoptera frugiperda 9 cells. |journal=Mol. Pharmacol. |volume=57 |issue= 5 |pages= 1034–44 |year= 2000 |pmid= 10779389 |doi=
*cite journal | author=Marazziti D, Ori M, Nardini M, "et al." |title=mRNA expression of serotonin receptors of type 2C and 5A in human resting lymphocytes. |journal=Neuropsychobiology |volume=43 |issue= 3 |pages= 123–6 |year= 2001 |pmid= 11287788 |doi=
*cite journal | author=Iwata N, Ozaki N, Inada T, Goldman D |title=Association of a 5-HT(5A) receptor polymorphism, Pro15Ser, to schizophrenia. |journal=Mol. Psychiatry |volume=6 |issue= 2 |pages= 217–9 |year= 2001 |pmid= 11317225 |doi= 10.1038/sj.mp.4000829
*cite journal | author=Grailhe R, Grabtree GW, Hen R |title=Human 5-HT(5) receptors: the 5-HT(5A) receptor is functional but the 5-HT(5B) receptor was lost during mammalian evolution. |journal=Eur. J. Pharmacol. |volume=418 |issue= 3 |pages= 157–67 |year= 2001 |pmid= 11343685 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Noda M, Yasuda S, Okada M, "et al." |title=Recombinant human serotonin 5A receptors stably expressed in C6 glioma cells couple to multiple signal transduction pathways. |journal=J. Neurochem. |volume=84 |issue= 2 |pages= 222–32 |year= 2003 |pmid= 12558985 |doi=
*cite journal | author=Scherer SW, Cheung J, MacDonald JR, "et al." |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423
*cite journal | author=Hillier LW, Fulton RS, Fulton LA, "et al." |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782
*cite journal | author=Khorana N, Smith C, Herrick-Davis K, "et al." |title=Binding of tetrahydrocarboline derivatives at human 5-HT5A receptors. |journal=J. Med. Chem. |volume=46 |issue= 18 |pages= 3930–7 |year= 2003 |pmid= 12930153 |doi= 10.1021/jm030080s
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Dietz BM, Mahady GB, Pauli GF, Farnsworth NR |title=Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro. |journal=Brain Res. Mol. Brain Res. |volume=138 |issue= 2 |pages= 191–7 |year= 2005 |pmid= 15921820 |doi= 10.1016/j.molbrainres.2005.04.009

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes