GPR77

G protein-coupled receptor 77, also known as GPR77, is a human gene.

PBB_Summary
section_title =
summary_text = The anaphylatoxins C3a, C4a, and C5a are cationic fragments generated during the complement cascade that participate in host defense. In the case of inappropriate complement activation, anaphylatoxins may be involved in autoimmunity and sepsis. C5L2 is coexpressed with the C5a receptor, C5AR (C5R1; MIM 113995), on polymorphonuclear neutrophils and may modulate C5AR activity (Gerard et al., 2005). [supplied by OMIM] cite web | title = Entrez Gene: GPR77 G protein-coupled receptor 77| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27202| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ohno M, Hirata T, Enomoto M, "et al." |title=A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells. |journal=Mol. Immunol. |volume=37 |issue= 8 |pages= 407–12 |year= 2000 |pmid= 11090875 |doi=10.1016/S0161-5890(00)00067-5
*cite journal | author=Lee DK, George SR, Cheng R, "et al." |title=Identification of four novel human G protein-coupled receptors expressed in the brain. |journal=Brain Res. Mol. Brain Res. |volume=86 |issue= 1-2 |pages= 13–22 |year= 2001 |pmid= 11165367 |doi=10.1016/S0169-328X(00)00242-4
*cite journal | author=Cain SA, Monk PN |title=The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74). |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7165–9 |year= 2002 |pmid= 11773063 |doi= 10.1074/jbc.C100714200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kalant D, Cain SA, Maslowska M, "et al." |title=The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77/acylation-stimulating protein. |journal=J. Biol. Chem. |volume=278 |issue= 13 |pages= 11123–9 |year= 2003 |pmid= 12540846 |doi= 10.1074/jbc.M206169200
*cite journal | author=Otto M, Hawlisch H, Monk PN, "et al." |title=C5a mutants are potent antagonists of the C5a receptor (CD88) and of C5L2: position 69 is the locus that determines agonism or antagonism. |journal=J. Biol. Chem. |volume=279 |issue= 1 |pages= 142–51 |year= 2004 |pmid= 14570896 |doi= 10.1074/jbc.M310078200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Huber-Lang M, Sarma JV, Rittirsch D, "et al." |title=Changes in the novel orphan, C5a receptor (C5L2), during experimental sepsis and sepsis in humans. |journal=J. Immunol. |volume=174 |issue= 2 |pages= 1104–10 |year= 2005 |pmid= 15634936 |doi=
*cite journal | author=Kalant D, MacLaren R, Cui W, "et al." |title=C5L2 is a functional receptor for acylation-stimulating protein. |journal=J. Biol. Chem. |volume=280 |issue= 25 |pages= 23936–44 |year= 2005 |pmid= 15833747 |doi= 10.1074/jbc.M406921200
*cite journal | author=Johswich K, Martin M, Thalmann J, "et al." |title=Ligand specificity of the anaphylatoxin C5L2 receptor and its regulation on myeloid and epithelial cell lines. |journal=J. Biol. Chem. |volume=281 |issue= 51 |pages= 39088–95 |year= 2007 |pmid= 17068344 |doi= 10.1074/jbc.M609734200
*cite journal | author=Scola AM, Higginbottom A, Partridge LJ, "et al." |title=The role of the N-terminal domain of the complement fragment receptor C5L2 in ligand binding. |journal=J. Biol. Chem. |volume=282 |issue= 6 |pages= 3664–71 |year= 2007 |pmid= 17158873 |doi= 10.1074/jbc.M609178200

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