Terlipressin

drugbox
IUPAC_name = (2"S")-1- [(4"S",7"S",10"S",13"S",16"S",19"S")-19- [2-
[2- [(2-Aminoacetyl)amino] acetyl] amino]
acetyl] amino] -13-benzyl-10-(2-carbamoylethyl)-
7-(carbamoylmethyl)-16- [(4-hydroxyphenyl)
methyl] -6,9,12,15,18-pentaoxo-1,2-dithia-5,8,
11,14,17-pentazacycloicosane-4-carbonyl] -"N"-
[(1"S")-5-amino-1-(carbamoylmethylcarbamoyl)
pentyl] pyrrolidine-2-carboxamide


CAS_number = 14636-12-5
ATC_prefix = H01
ATC_suffix = BA04
ATC_supplemental =
PubChem = 72081
DrugBank = EXPT03310
C=52 | H=74 | N=16 | O=15 | S=2
molecular_weight = 1227.37 g/mol
bioavailability =
protein_bound = ~30%
metabolism =
elimination_half-life =
pregnancy_category =
legal_status =
routes_of_administration = IV

Terlipressin is an analogue of vasopressin used as a vasoactive drug in the management of hypotension. It has been found to be effective when norepinephrine does not help.

Indications for use include norepinephrine-resistant septic shockcite journal |author=O'Brien A, Clapp L, Singer M |title=Terlipressin for norepinephrine-resistant septic shock |journal=Lancet |volume=359 |issue=9313 |pages=1209–10 |year=2002 |pmid=11955542 |doi=10.1016/S0140-6736(02)08225-9] and hepatorenal syndrome.cite journal |author=Uriz J, Ginès P, Cárdenas A, Sort P, Jiménez W, Salmerón J, Bataller R, Mas A, Navasa M, Arroyo V, Rodés J |title=Terlipressin plus albumin infusion: an effective and safe therapy of hepatorenal syndrome |journal=J Hepatol |volume=33 |issue=1 |pages=43–8 |year=2000 |pmid=10905585 |doi=10.1016/S0168-8278(00)80158-0] In addition, it is used in bleeding esophageal varices.cite journal |author=Ioannou G, Doust J, Rockey D |title=Terlipressin for acute esophageal variceal hemorrhage |journal=Cochrane Database Syst Rev |volume= |issue= |pages=CD002147 |year= |pmid=12535432 |doi=10.1002/14651858.CD002147]

Terlipressin is marketed under the brand name "Glypressin" ("Ferring Pharmaceuticals").

ee also

* Desmopressin

References