Calcitonin receptor-like (CALCRL), also known as the calcitonin receptor-like receptor (CRLR), is a human gene.cite journal | author = Aiyar N, Rand K, Elshourbagy NA, Zeng Z, Adamou JE, Bergsma DJ, Li Y | title = A cDNA encoding the calcitonin gene-related peptide type 1 receptor | journal = J. Biol. Chem. | volume = 271 | issue = 19 | pages = 11325–9 | year = 1996 | month = May | pmid = 8626685 | doi = 10.1074/jbc.271.19.11325 | url = | issn = ]


The protein encoded by this gene is a G protein-coupled receptor related to the calcitonin receptor. CALCRL is linked to one of three single transmembrane domain receptor activity-modifying proteins (RAMPs) that are essential for functional activity.

The association of CALCRL with different RAMP proteins produces different receptors:cite journal | author = McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM | title = RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor | journal = Nature | volume = 393 | issue = 6683 | pages = 333–9 | year = 1998 | month = May | pmid = 9620797 | doi = 10.1038/30666 | url = | issn = ] cite journal | author = Foord SM, Marshall FH | title = RAMPs: accessory proteins for seven transmembrane domain receptors | journal = Trends Pharmacol. Sci. | volume = 20 | issue = 5 | pages = 184–7 | year = 1999 | month = May | pmid = 10354609 | doi = 10.1016/S0165-6147(99)01347-4 | url = | issn = ]
* with RAMP1: produces a CGRP receptor
* with RAMP2: produces an adrenomedullin (AM) receptorcite journal | author = Kamitani S, Asakawa M, Shimekake Y, Kuwasako K, Nakahara K, Sakata T | title = The RAMP2/CRLR complex is a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells | journal = FEBS Lett. | volume = 448 | issue = 1 | pages = 111–4 | year = 1999 | month = April | pmid = 10217420 | doi = 10.1016/S0014-5793(99)00358-0 | url = | issn = ]
* with RAMP3: produces a dual CGRP/AM receptor

These receptors are linked to the G protein Gs,cite web | url =,%20amylin,%20CGRP%20and%20adrenomedullin%20receptors, | title = Receptor properties | author = | authorlink = | coauthors = | date = | format = | work = SenseLab Project: Membrane properties resource | publisher = Yale University | pages = | language = | archiveurl = | archivedate = | quote = | accessdate = 2008-09-28] which activates adenylate cyclase and activation results in the generation of intracellular cyclic adenosine monophosphate (cAMP).


Further reading

citations =
*cite journal | author=Born W, Muff R, Fischer JA |title=Functional interaction of G protein-coupled receptors of the adrenomedullin peptide family with accessory receptor-activity-modifying proteins (RAMP). |journal=Microsc. Res. Tech. |volume=57 |issue= 1 |pages= 14–22 |year= 2002 |pmid= 11921352 |doi= 10.1002/jemt.10051
*cite journal | author=Yallampalli C, Chauhan M, Thota CS, "et al." |title=Calcitonin gene-related peptide in pregnancy and its emerging receptor heterogeneity. |journal=Trends Endocrinol. Metab. |volume=13 |issue= 6 |pages= 263–9 |year= 2003 |pmid= 12128288 |doi=
*cite journal | author=Foord SM, Craig RK |title=Isolation and characterisation of a human calcitonin-gene-related-peptide receptor. |journal=Eur. J. Biochem. |volume=170 |issue= 1-2 |pages= 373–9 |year= 1988 |pmid= 2826160 |doi=
*cite journal | author=Skofitsch G, Jacobowitz DM |title=Autoradiographic distribution of 125I calcitonin gene-related peptide binding sites in the rat central nervous system. |journal=Peptides |volume=6 |issue= 5 |pages= 975–86 |year= 1986 |pmid= 3001670 |doi=
*cite journal | author=Flühmann B, Muff R, Hunziker W, "et al." |title=A human orphan calcitonin receptor-like structure. |journal=Biochem. Biophys. Res. Commun. |volume=206 |issue= 1 |pages= 341–7 |year= 1995 |pmid= 7818539 |doi= 10.1006/bbrc.1995.1047
*cite journal | author=Aiyar N, Rand K, Elshourbagy NA, "et al." |title=A cDNA encoding the calcitonin gene-related peptide type 1 receptor. |journal=J. Biol. Chem. |volume=271 |issue= 19 |pages= 11325–9 |year= 1996 |pmid= 8626685 |doi=
*cite journal | author=McLatchie LM, Fraser NJ, Main MJ, "et al." |title=RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. |journal=Nature |volume=393 |issue= 6683 |pages= 333–9 |year= 1998 |pmid= 9620797 |doi= 10.1038/30666
*cite journal | author=Sams A, Jansen-Olesen I |title=Expression of calcitonin receptor-like receptor and receptor-activity-modifying proteins in human cranial arteries. |journal=Neurosci. Lett. |volume=258 |issue= 1 |pages= 41–4 |year= 1999 |pmid= 9876047 |doi=
*cite journal | author=Kamitani S, Asakawa M, Shimekake Y, "et al." |title=The RAMP2/CRLR complex is a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells. |journal=FEBS Lett. |volume=448 |issue= 1 |pages= 111–4 |year= 1999 |pmid= 10217420 |doi=
*cite journal | author=Aldecoa A, Gujer R, Fischer JA, Born W |title=Mammalian calcitonin receptor-like receptor/receptor activity modifying protein complexes define calcitonin gene-related peptide and adrenomedullin receptors in Drosophila Schneider 2 cells. |journal=FEBS Lett. |volume=471 |issue= 2-3 |pages= 156–60 |year= 2000 |pmid= 10767413 |doi=
*cite journal | author=Frayon S, Cueille C, Gnidéhou S, "et al." |title=Dexamethasone increases RAMP1 and CRLR mRNA expressions in human vascular smooth muscle cells. |journal=Biochem. Biophys. Res. Commun. |volume=270 |issue= 3 |pages= 1063–7 |year= 2000 |pmid= 10772950 |doi= 10.1006/bbrc.2000.2552
*cite journal | author=Kuwasako K, Shimekake Y, Masuda M, "et al." |title=Visualization of the calcitonin receptor-like receptor and its receptor activity-modifying proteins during internalization and recycling. |journal=J. Biol. Chem. |volume=275 |issue= 38 |pages= 29602–9 |year= 2000 |pmid= 10882736 |doi= 10.1074/jbc.M004534200
*cite journal | author=Evans BN, Rosenblatt MI, Mnayer LO, "et al." |title=CGRP-RCP, a novel protein required for signal transduction at calcitonin gene-related peptide and adrenomedullin receptors. |journal=J. Biol. Chem. |volume=275 |issue= 40 |pages= 31438–43 |year= 2000 |pmid= 10903324 |doi= 10.1074/jbc.M005604200
*cite journal | author=Hilairet S, Foord SM, Marshall FH, Bouvier M |title=Protein-protein interaction and not glycosylation determines the binding selectivity of heterodimers between the calcitonin receptor-like receptor and the receptor activity-modifying proteins. |journal=J. Biol. Chem. |volume=276 |issue= 31 |pages= 29575–81 |year= 2001 |pmid= 11387328 |doi= 10.1074/jbc.M102722200
*cite journal | author=Kamitani S, Sakata T |title=Glycosylation of human CRLR at Asn123 is required for ligand binding and signaling. |journal=Biochim. Biophys. Acta |volume=1539 |issue= 1-2 |pages= 131–9 |year= 2001 |pmid= 11389975 |doi=
*cite journal | author=Nikitenko LL, Brown NS, Smith DM, "et al." |title=Differential and cell-specific expression of calcitonin receptor-like receptor and receptor activity modifying proteins in the human uterus. |journal=Mol. Hum. Reprod. |volume=7 |issue= 7 |pages= 655–64 |year= 2001 |pmid= 11420389 |doi=
*cite journal | author=Hilairet S, Bélanger C, Bertrand J, "et al." |title=Agonist-promoted internalization of a ternary complex between calcitonin receptor-like receptor, receptor activity-modifying protein 1 (RAMP1), and beta-arrestin. |journal=J. Biol. Chem. |volume=276 |issue= 45 |pages= 42182–90 |year= 2001 |pmid= 11535606 |doi= 10.1074/jbc.M107323200
*cite journal | author=Aiyar N, Disa J, Pullen M, Nambi P |title=Receptor activity modifying proteins interaction with human and porcine calcitonin receptor-like receptor (CRLR) in HEK-293 cells. |journal=Mol. Cell. Biochem. |volume=224 |issue= 1-2 |pages= 123–33 |year= 2002 |pmid= 11693189 |doi=
*cite journal | author=Hagner S, Haberberger RV, Overkamp D, "et al." |title=Expression and distribution of calcitonin receptor-like receptor in human hairy skin. |journal=Peptides |volume=23 |issue= 1 |pages= 109–16 |year= 2002 |pmid= 11814625 |doi=

External links


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