Lysophosphatidic acid

Lysophosphatidic acid

Chembox new
ImageFile = Lysophosphatidic_acid.svg‎
ImageSize = 250px
IUPACName = (2-hydroxy-3-phosphonooxypropyl) (Z)-octadec-9-enoate
OtherNames = LPA
Section1 = Chembox Identifiers
CASNo = 22002-87-5
PubChem = 5497152
SMILES = CCCCCCCCC=C/CCCCCCCC(=O)OCC(COP(=O)(O)O)O
MeSHName = lysophosphatidic+acid

Section2 = Chembox Properties
Formula = C21H41O7P
MolarMass = 436.52 g/mol
Appearance =
Density =
MeltingPt =
BoilingPt =

Section3 = Chembox Hazards
Solubility =
MainHazards =
FlashPt =
Autoignition =

Lysophosphatidic acid (LPA) is a phospholipid derivative that acts as a potent signaling molecule. There are a number of potential routes to its biosynthesis, but the most well-characterized is by the action of a lysophospholipase D called autotaxin, which removes the choline group from lysophosphatidylcholine. LPA acts as a potent mitogen due to its activation of three high-affinity G-protein-coupled receptors called LPA1, LPA2, and LPA3 (also known as EDG2, EDG4, and EDG7). Additional, newly identified LPA receptors include LPA4 (p2y9/GPR23), LPA5 (GPR92) and LPA6 (GPR87).

Because of its ability to stimulate cell proliferation, aberrant LPA-signaling has been linked to cancer in numerous ways. Dysregulation of autotaxin or the LPA receptors can lead to hyperproliferation, which may contribute to oncogenesis and metastasis.

Downstream of LPA receptor activation, the small GTPase Rho can be activated, subsequently activating Rho kinase. This can lead to the formation of stress fibers and cell migration through the inhibition of myosin light-chain phosphatase.

Lysophosphatidic acid is also an intermediate in the synthesis of phosphatidic acid.


=Additional

ee also

* Autotaxin
* phosphatidic acid
* Lysophospholipid receptor

References

* Moolenar, W.H., "Lysophosphatidic Acid, a Multifunctional Phospholipid Messenger." J. Biol. Chem. 1995. (270)22:12949. [http://www.jbc.org/cgi/content/full/270/22/12949 Article] .
* Mills, G.B., Moolenaar, W.H., "The Emerging role of lysophosphatidic acid in cancer." Nat. Rev. Cancer. 2003. (8):582. [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=12894246&query_hl=1&itool=pubmed_docsum Article]


Wikimedia Foundation. 2010.

Игры ⚽ Поможем решить контрольную работу

Look at other dictionaries:

  • lysophosphatidic acid — A phosphatidic acid in which only one of the two hydroxyl groups of the glycerophosphate is esterified; most commonly, when carbon 1 of the glycerol moiety is esterified ( e.g., 1 acylglycerol 3 phosphate). l. acyltransferase, 1 acylglycerol 3… …   Medical dictionary

  • lysophosphatidic — adjective Describing a phosphatidic acid in which one or both acyl derivatives have been removed by hydrolysis. See Also: lysophospholipid …   Wiktionary

  • Phosphatidic acid — Chembox new ImageFile = Phosphatidate2.png ImageSize = IUPACName = OtherNames = 1,2 Diacylglycerol 3 phosphate, phosphatidic acid Section1 = Chembox Identifiers CASNo = PubChem = 5460104 SMILES = MeSHName = Phosphatidic+Acids Section2 = Chembox… …   Wikipedia

  • ACP6 — Acid phosphatase 6, lysophosphatidic, also known as ACP6, is a human gene.cite web | title = Entrez Gene: ACP6 acid phosphatase 6, lysophosphatidic| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=51205|… …   Wikipedia

  • LPAR6 — Lysophosphatidic acid receptor 6 Identifiers Symbols LPAR6; ARWH1; LAH3; MGC120358; P2RY5; P2Y5 External IDs …   Wikipedia

  • LPAR4 — Lysophosphatidic acid receptor 4 Identifiers Symbols LPAR4; GPR23; LPA4; P2RY9; P2Y5 LIKE; P2Y9 External IDs …   Wikipedia

  • EDG4 — (endothelial differentiation gene 2) is a human gene which encodes a G protein coupled receptor which binds the lipid signaling molecule lysophosphatidic acid (LPA). Hence this receptor is also known as LPA2.cite web | title = Entrez Gene: EDG4… …   Wikipedia

  • EDG2 — (endothelial differentiation gene 2) is a human gene which encodes a G protein coupled receptor which binds the lipid signaling molecule lysophosphatidic acid (LPA). Hence this receptor is also known as LPA1.cite web | title = Entrez Gene: EDG2… …   Wikipedia

  • EDG7 — Endothelial differentiation, lysophosphatidic acid G protein coupled receptor, 7, also known as EDG7, is a human gene.cite web | title = Entrez Gene: EDG7 endothelial differentiation, lysophosphatidic acid G protein coupled receptor, 7| url =… …   Wikipedia

  • AGPAT2 — 1 acylglycerol 3 phosphate O acyltransferase 2 (lysophosphatidic acid acyltransferase, beta), also known as AGPAT2, is a human gene.cite web | title = Entrez Gene: AGPAT2 1 acylglycerol 3 phosphate O acyltransferase 2 (lysophosphatidic acid… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”