EDG4 (endothelial differentiation gene 2) is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule lysophosphatidic acid (LPA). Hence this receptor is also known as LPA2.cite web | title = Entrez Gene: EDG4 endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9170| accessdate = ]

section_title =
summary_text = This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins.cite web | title = Entrez Gene: EDG4 endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9170| accessdate = ]

ee also

* Lysophospholipid receptor


Further reading

citations =
*cite journal | author=Spiegel S |title=Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors. |journal=Ann. N. Y. Acad. Sci. |volume=905 |issue= |pages= 54–60 |year= 2000 |pmid= 10818441 |doi=
*cite journal | author=Contos JJ, Ishii I, Chun J |title=Lysophosphatidic acid receptors. |journal=Mol. Pharmacol. |volume=58 |issue= 6 |pages= 1188–96 |year= 2001 |pmid= 11093753 |doi=
*cite journal | author=An S, Bleu T, Hallmark OG, Goetzl EJ |title=Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid. |journal=J. Biol. Chem. |volume=273 |issue= 14 |pages= 7906–10 |year= 1998 |pmid= 9525886 |doi=
*cite journal | author=An S, Bleu T, Zheng Y, Goetzl EJ |title=Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization. |journal=Mol. Pharmacol. |volume=54 |issue= 5 |pages= 881–8 |year= 1998 |pmid= 9804623 |doi=
*cite journal | author=Goetzl EJ, Dolezalova H, Kong Y, "et al." |title=Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer. |journal=Cancer Res. |volume=59 |issue= 20 |pages= 5370–5 |year= 1999 |pmid= 10537322 |doi=
*cite journal | author=Contos JJ, Chun J |title=Genomic characterization of the lysophosphatidic acid receptor gene, lp(A2)/Edg4, and identification of a frameshift mutation in a previously characterized cDNA. |journal=Genomics |volume=64 |issue= 2 |pages= 155–69 |year= 2000 |pmid= 10729222 |doi= 10.1006/geno.2000.6122
*cite journal | author=Bandoh K, Aoki J, Taira A, "et al." |title=Lysophosphatidic acid (LPA) receptors of the EDG family are differentially activated by LPA species. Structure-activity relationship of cloned LPA receptors. |journal=FEBS Lett. |volume=478 |issue= 1-2 |pages= 159–65 |year= 2000 |pmid= 10922489 |doi=
*cite journal | author=Young KW, Bootman MD, Channing DR, "et al." |title=Lysophosphatidic acid-induced Ca2+ mobilization requires intracellular sphingosine 1-phosphate production. Potential involvement of endogenous EDG-4 receptors. |journal=J. Biol. Chem. |volume=275 |issue= 49 |pages= 38532–9 |year= 2001 |pmid= 10954727 |doi= 10.1074/jbc.M006631200
*cite journal | author=Zheng Y, Voice JK, Kong Y, Goetzl EJ |title=Altered expression and functional profile of lysophosphatidic acid receptors in mitogen-activated human blood T lymphocytes. |journal=FASEB J. |volume=14 |issue= 15 |pages= 2387–9 |year= 2001 |pmid= 11024010 |doi= 10.1096/fj.00-0492fje
*cite journal | author=Hama K, Bandoh K, Kakehi Y, "et al." |title=Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA-binding proteins in activation of LPA receptors. |journal=FEBS Lett. |volume=523 |issue= 1-3 |pages= 187–92 |year= 2002 |pmid= 12123830 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Fujita T, Miyamoto S, Onoyama I, "et al." |title=Expression of lysophosphatidic acid receptors and vascular endothelial growth factor mediating lysophosphatidic acid in the development of human ovarian cancer. |journal=Cancer Lett. |volume=192 |issue= 2 |pages= 161–9 |year= 2003 |pmid= 12668280 |doi=
*cite journal | author=Hu YL, Albanese C, Pestell RG, Jaffe RB |title=Dual mechanisms for lysophosphatidic acid stimulation of human ovarian carcinoma cells. |journal=J. Natl. Cancer Inst. |volume=95 |issue= 10 |pages= 733–40 |year= 2003 |pmid= 12759391 |doi=
*cite journal | author=Xu J, Lai YJ, Lin WC, Lin FT |title=TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor. |journal=J. Biol. Chem. |volume=279 |issue= 11 |pages= 10459–68 |year= 2004 |pmid= 14688263 |doi= 10.1074/jbc.M311891200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Grimwood J, Gordon LA, Olsen A, "et al." |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399
*cite journal | author=Oh YS, Jo NW, Choi JW, "et al." |title=NHERF2 specifically interacts with LPA2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-beta3 activation. |journal=Mol. Cell. Biol. |volume=24 |issue= 11 |pages= 5069–79 |year= 2004 |pmid= 15143197 |doi= 10.1128/MCB.24.11.5069-5079.2004
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504

External links

* [http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1338 IUPHAR GPCR Database - Lysophospholipid receptors]

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