- EDG2
EDG2 (endothelial differentiation gene 2) is a human
gene which encodes aG protein-coupled receptor which binds the lipid signaling moleculelysophosphatidic acid (LPA). Hence this receptor is also known as LPA1.cite web | title = Entrez Gene: EDG2 endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1902| accessdate = ]PBB_Summary
section_title =
summary_text = The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Alternative splicing of this gene has been observed and two transcript variants have been described, each encoding identical proteins. An alternate translation start codon has been identified, which results in isoforms differing in the N-terminal extracellular tail. In addition, an alternate polyadenylation site has been reported.cite web | title = Entrez Gene: EDG2 endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1902| accessdate = ]ee also
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Lysophospholipid receptor References
Further reading
PBB_Further_reading
citations =
*cite journal | author=An S, Goetzl EJ, Lee H |title=Signaling mechanisms and molecular characteristics of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate. |journal=J. Cell. Biochem. Suppl. |volume=30-31 |issue= |pages= 147–57 |year= 1999 |pmid= 9893266 |doi=
*cite journal | author=Contos JJ, Ishii I, Chun J |title=Lysophosphatidic acid receptors. |journal=Mol. Pharmacol. |volume=58 |issue= 6 |pages= 1188–96 |year= 2001 |pmid= 11093753 |doi=
*cite journal | author=Hecht JH, Weiner JA, Post SR, Chun J |title=Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex. |journal=J. Cell Biol. |volume=135 |issue= 4 |pages= 1071–83 |year= 1997 |pmid= 8922387 |doi=
*cite journal | author=Moolenaar WH, Kranenburg O, Postma FR, Zondag GC |title=Lysophosphatidic acid: G-protein signalling and cellular responses. |journal=Curr. Opin. Cell Biol. |volume=9 |issue= 2 |pages= 168–73 |year= 1997 |pmid= 9069262 |doi=
*cite journal | author=An S, Dickens MA, Bleu T, "et al." |title=Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid. |journal=Biochem. Biophys. Res. Commun. |volume=231 |issue= 3 |pages= 619–22 |year= 1997 |pmid= 9070858 |doi= 10.1006/bbrc.1997.6150
*cite journal | author=Fukushima N, Kimura Y, Chun J |title=A single receptor encoded by vzg-1/lpA1/edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 11 |pages= 6151–6 |year= 1998 |pmid= 9600933 |doi=
*cite journal | author=An S, Bleu T, Zheng Y, Goetzl EJ |title=Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization. |journal=Mol. Pharmacol. |volume=54 |issue= 5 |pages= 881–8 |year= 1998 |pmid= 9804623 |doi=
*cite journal | author=Cervera P, Tirard M, Barron S, "et al." |title=Immunohistological localization of the myelinating cell-specific receptor LP(A1). |journal=Glia |volume=38 |issue= 2 |pages= 126–36 |year= 2002 |pmid= 11948806 |doi=
*cite journal | author=Hama K, Bandoh K, Kakehi Y, "et al." |title=Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA-binding proteins in activation of LPA receptors. |journal=FEBS Lett. |volume=523 |issue= 1-3 |pages= 187–92 |year= 2002 |pmid= 12123830 |doi=
*cite journal | author=Van Leeuwen FN, Olivo C, Grivell S, "et al." |title=Rac activation by lysophosphatidic acid LPA1 receptors through the guanine nucleotide exchange factor Tiam1. |journal=J. Biol. Chem. |volume=278 |issue= 1 |pages= 400–6 |year= 2003 |pmid= 12393875 |doi= 10.1074/jbc.M210151200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Murph MM, Scaccia LA, Volpicelli LA, Radhakrishna H |title=Agonist-induced endocytosis of lysophosphatidic acid-coupled LPA1/EDG-2 receptors via a dynamin2- and Rab5-dependent pathway. |journal=J. Cell. Sci. |volume=116 |issue= Pt 10 |pages= 1969–80 |year= 2004 |pmid= 12668728 |doi= 10.1242/jcs.00397
*cite journal | author=Shida D, Kitayama J, Yamaguchi H, "et al." |title=Lysophosphatidic acid (LPA) enhances the metastatic potential of human colon carcinoma DLD1 cells through LPA1. |journal=Cancer Res. |volume=63 |issue= 7 |pages= 1706–11 |year= 2003 |pmid= 12670925 |doi=
*cite journal | author=Matsuda A, Suzuki Y, Honda G, "et al." |title=Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. |journal=Oncogene |volume=22 |issue= 21 |pages= 3307–18 |year= 2003 |pmid= 12761501 |doi= 10.1038/sj.onc.1206406
*cite journal | author=Xu J, Lai YJ, Lin WC, Lin FT |title=TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor. |journal=J. Biol. Chem. |volume=279 |issue= 11 |pages= 10459–68 |year= 2004 |pmid= 14688263 |doi= 10.1074/jbc.M311891200
*cite journal | author=Komuro Y, Watanabe T, Kitayama J, "et al." |title=The Immunohistochemical expression of endothelial cell differentiation gene-2 receptor in human colorectal adenomas. |journal=Hepatogastroenterology |volume=50 |issue= 54 |pages= 1770–3 |year= 2004 |pmid= 14696401 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Kaneider NC, Lindner J, Feistritzer C, "et al." |title=The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor. |journal=FASEB J. |volume=18 |issue= 11 |pages= 1309–11 |year= 2005 |pmid= 15208267 |doi= 10.1096/fj.03-1050fjeExternal links
* [http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1338 IUPHAR GPCR Database - Lysophospholipid receptors]
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