Lysophospholipid receptor

The Lysophospholipid receptor (LPL-R) group are members of the G protein-coupled receptor family of integral membrane proteins that are important for lipid signaling.cite journal |author=Chun J, Goetzl EJ, Hla T, Igarashi Y, Lynch KR, Moolenaar W, Pyne S, Tigyi G |title=International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature|journal=Pharmacol Rev |volume= 54 |issue= 2|pages=265–9 |year= 2002 | pmid = 12037142 |doi=10.1124/pr.54.2.265] In humans there are eight LPL receptors, each encoded by a separate gene. These LPL receptor genes are also sometimes referred to as "Edg” (an acronym for endothelial differentiation gene).

Ligands

The ligands for LPL-R group are the lysophospholipid extracellular signaling molecules, lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P).

Origin of name

The term 'lysophospholipid' (LPL) refers to any phospholipid that is missing one of its two O-acyl chains. Thus, LPLs have a free alcohol in either the sn-1 or sn-2 position. The prefix 'lyso-' comes from the fact that lysophospholipids were originally found to be hemolytic however it is now used to refer generally to phospholipids missing an acyl chain. LPLs are usually the result of phospholipase A-type enzymatic activity on regular phospholipids such as phosphatidylcholine or phosphatidic acid, although they can also be generated by the acylation of glycerophospholipids or the phosphorylation of monoacylglycerols. Some LPLs serve important signaling functions such as lysophosphatidic acid.

Function

LPL receptor ligands bind to and activate their cognate receptors located in the cell membrane. Depending on which ligand, receptor, and cell type is involved, the activated receptor can have a range of effects on the cell. These include primary effects of inhibition of adenylyl cyclase and release of calcium from the endoplasmic reticulum, as well as secondary effects of preventing apoptosis and increasing cell proliferation.cite journal |author=Meyer zu Heringdorf D, Jakobs KH |title=Lysophospholipid receptors: signalling, pharmacology and regulation by lysophospholipid metabolism |journal=Biochim Biophys Acta |volume= 1768 |issue= 4|pages=923–40 |year= 2007 | doi = 10.1016/j.bbamem.2006.09.026 | pmid = 17078925]

Group members

The following is a list of the eight known human LPL receptors:

ee also

*Lipid signaling

References

reflist

External links

* [http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1338 IUPHAR GPCR Database - Lysophospholipid receptors]
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