AGPAT2

AGPAT2

1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta), also known as AGPAT2, is a human gene.cite web | title = Entrez Gene: AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10555| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. The protein is located within the endoplasmic reticulum membrane and converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. Mutations in this gene have been associated with congenital generalized lipodystrophy (CGL), or Berardinelli-Seip syndrome, a disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.cite web | title = Entrez Gene: AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10555| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Garg A |title=Acquired and inherited lipodystrophies. |journal=N. Engl. J. Med. |volume=350 |issue= 12 |pages= 1220–34 |year= 2004 |pmid= 15028826 |doi= 10.1056/NEJMra025261
*cite journal | author=West J, Tompkins CK, Balantac N, "et al." |title=Cloning and expression of two human lysophosphatidic acid acyltransferase cDNAs that enhance cytokine-induced signaling responses in cells. |journal=DNA Cell Biol. |volume=16 |issue= 6 |pages= 691–701 |year= 1997 |pmid= 9212163 |doi=
*cite journal | author=Eberhardt C, Gray PW, Tjoelker LW |title=Human lysophosphatidic acid acyltransferase. cDNA cloning, expression, and localization to chromosome 9q34.3. |journal=J. Biol. Chem. |volume=272 |issue= 32 |pages= 20299–305 |year= 1997 |pmid= 9242711 |doi=
*cite journal | author=Stamps AC, Elmore MA, Hill ME, "et al." |title=A human cDNA sequence with homology to non-mammalian lysophosphatidic acid acyltransferases. |journal=Biochem. J. |volume=326 ( Pt 2) |issue= |pages= 455–61 |year= 1997 |pmid= 9291118 |doi=
*cite journal | author=Aguado B, Campbell RD |title=Characterization of a human lysophosphatidic acid acyltransferase that is encoded by a gene located in the class III region of the human major histocompatibility complex. |journal=J. Biol. Chem. |volume=273 |issue= 7 |pages= 4096–105 |year= 1998 |pmid= 9461603 |doi=
*cite journal | author=Garg A, Wilson R, Barnes R, "et al." |title=A gene for congenital generalized lipodystrophy maps to human chromosome 9q34. |journal=J. Clin. Endocrinol. Metab. |volume=84 |issue= 9 |pages= 3390–4 |year= 1999 |pmid= 10487716 |doi=
*cite journal | author=Agarwal AK, Arioglu E, De Almeida S, "et al." |title=AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34. |journal=Nat. Genet. |volume=31 |issue= 1 |pages= 21–3 |year= 2002 |pmid= 11967537 |doi= 10.1038/ng880
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Simha V, Garg A |title=Phenotypic heterogeneity in body fat distribution in patients with congenital generalized lipodystrophy caused by mutations in the AGPAT2 or seipin genes. |journal=J. Clin. Endocrinol. Metab. |volume=88 |issue= 11 |pages= 5433–7 |year= 2003 |pmid= 14602785 |doi=
*cite journal | author=Brandenberger R, Wei H, Zhang S, "et al." |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971
*cite journal | author=Fu M, Kazlauskaite R, Baracho Mde F, "et al." |title=Mutations in Gng3lg and AGPAT2 in Berardinelli-Seip congenital lipodystrophy and Brunzell syndrome: phenotype variability suggests important modifier effects. |journal=J. Clin. Endocrinol. Metab. |volume=89 |issue= 6 |pages= 2916–22 |year= 2004 |pmid= 15181077 |doi= 10.1210/jc.2003-030485
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Haque W, Garg A, Agarwal AK |title=Enzymatic activity of naturally occurring 1-acylglycerol-3-phosphate-O-acyltransferase 2 mutants associated with congenital generalized lipodystrophy. |journal=Biochem. Biophys. Res. Commun. |volume=327 |issue= 2 |pages= 446–53 |year= 2005 |pmid= 15629135 |doi= 10.1016/j.bbrc.2004.12.024
*cite journal | author=Niesporek S, Denkert C, Weichert W, "et al." |title=Expression of lysophosphatidic acid acyltransferase beta (LPAAT-beta) in ovarian carcinoma: correlation with tumour grading and prognosis. |journal=Br. J. Cancer |volume=92 |issue= 9 |pages= 1729–36 |year= 2005 |pmid= 15841084 |doi= 10.1038/sj.bjc.6602528
*cite journal | author=Gomes KB, Pardini VC, Ferreira AC, Fernandes AP |title=Phenotypic heterogeneity in biochemical parameters correlates with mutations in AGPAT2 or Seipin genes among Berardinelli-Seip congenital lipodystrophy patients. |journal=J. Inherit. Metab. Dis. |volume=28 |issue= 6 |pages= 1123–31 |year= 2006 |pmid= 16435205 |doi= 10.1007/s10545-005-0038-5
*cite journal | author=Lloyd EE, Gaubatz JW, Burns AR, Pownall HJ |title=Sustained elevations in NEFA induce cyclooxygenase-2 activity and potentiate THP-1 macrophage foam cell formation. |journal=Atherosclerosis |volume=192 |issue= 1 |pages= 49–55 |year= 2007 |pmid= 16870193 |doi= 10.1016/j.atherosclerosis.2006.06.014

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