Thromboxane receptor

Thromboxane receptor

The thromboxane receptor is a protein on the surface of cells in the endothelium of blood vessels and in the placenta which interacts with the eicosanoid lipid thromboxane. It is a G-protein coupled receptors coupled to the G protein Gq.cite journal | author = Abe T, Takeuchi K, Takahashi N, Tsutsumi E, Taniyama Y, Abe K | title = Rat kidney thromboxane receptor: molecular cloning, signal transduction, and intrarenal expression localization | journal = J. Clin. Invest. | volume = 96 | issue = 2 | pages = 657–64 | year = 1995 | pmid = 7635958 | doi = | issn = | url = http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=7635958 ]

Gene

The gene responsible for the thromboxane receptor, TBXA2R is found on chromosome 19 and spans 15 kilobases. Thromboxane is a potent stimulator for platelet aggregation and clot formation and also plays a role in vascular tone. The thromboxane receptor is a member of the family of G protein-coupled receptors. Mutation of the receptor can lead to a bleeding disorder.

ee also

* Eicosanoid receptor

References

Further reading

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citations =
*cite journal | author=Namba T, Narumiya S |title= [Thromboxane A2 receptor; structure, function and tissue distribution] |journal=Nippon Rinsho |volume=51 |issue= 1 |pages= 233–40 |year= 1993 |pmid= 8433523 |doi=
*cite journal | author=Murugappan S, Shankar H, Kunapuli SP |title=Platelet receptors for adenine nucleotides and thromboxane A2. |journal=Semin. Thromb. Hemost. |volume=30 |issue= 4 |pages= 411–8 |year= 2005 |pmid= 15354262 |doi= 10.1055/s-2004-833476
*cite journal | author=Hirata M, Hayashi Y, Ushikubi F, "et al." |title=Cloning and expression of cDNA for a human thromboxane A2 receptor. |journal=Nature |volume=349 |issue= 6310 |pages= 617–20 |year= 1991 |pmid= 1825698 |doi= 10.1038/349617a0
*cite journal | author=Raychowdhury MK, Yukawa M, Collins LJ, "et al." |title=Alternative splicing produces a divergent cytoplasmic tail in the human endothelial thromboxane A2 receptor. |journal=J. Biol. Chem. |volume=270 |issue= 12 |pages= 7011 |year= 1995 |pmid= 7896853 |doi=
*cite journal | author=Hirata T, Kakizuka A, Ushikubi F, "et al." |title=Arg60 to Leu mutation of the human thromboxane A2 receptor in a dominantly inherited bleeding disorder. |journal=J. Clin. Invest. |volume=94 |issue= 4 |pages= 1662–7 |year= 1994 |pmid= 7929844 |doi=
*cite journal | author=D'Angelo DD, Davis MG, Ali S, Dorn GW |title=Cloning and pharmacologic characterization of a thromboxane A2 receptor from K562 (human chronic myelogenous leukemia) cells. |journal=J. Pharmacol. Exp. Ther. |volume=271 |issue= 2 |pages= 1034–41 |year= 1994 |pmid= 7965765 |doi=
*cite journal | author=Raychowdhury MK, Yukawa M, Collins LJ, "et al." |title=Alternative splicing produces a divergent cytoplasmic tail in the human endothelial thromboxane A2 receptor. |journal=J. Biol. Chem. |volume=269 |issue= 30 |pages= 19256–61 |year= 1994 |pmid= 8034687 |doi=
*cite journal | author=Borg C, Lim CT, Yeomans DC, "et al." |title=Purification of rat brain, rabbit aorta, and human platelet thromboxane A2/prostaglandin H2 receptors by immunoaffinity chromatography employing anti-peptide and anti-receptor antibodies. |journal=J. Biol. Chem. |volume=269 |issue= 8 |pages= 6109–16 |year= 1994 |pmid= 8119956 |doi=
*cite journal | author=Nüsing RM, Hirata M, Kakizuka A, "et al." |title=Characterization and chromosomal mapping of the human thromboxane A2 receptor gene. |journal=J. Biol. Chem. |volume=268 |issue= 33 |pages= 25253–9 |year= 1993 |pmid= 8227091 |doi=
*cite journal | author=Funk CD, Furci L, Moran N, Fitzgerald GA |title=Point mutation in the seventh hydrophobic domain of the human thromboxane A2 receptor allows discrimination between agonist and antagonist binding sites. |journal=Mol. Pharmacol. |volume=44 |issue= 5 |pages= 934–9 |year= 1994 |pmid= 8246916 |doi=
*cite journal | author=Schwengel DA, Nouri N, Meyers DA, Levitt RC |title=Linkage mapping of the human thromboxane A2 receptor (TBXA2R) to chromosome 19p13.3 using transcribed 3' untranslated DNA sequence polymorphisms. |journal=Genomics |volume=18 |issue= 2 |pages= 212–5 |year= 1994 |pmid= 8288221 |doi= 10.1006/geno.1993.1457
*cite journal | author=Offermanns S, Laugwitz KL, Spicher K, Schultz G |title=G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 2 |pages= 504–8 |year= 1994 |pmid= 8290554 |doi=
*cite journal | author=Hirata T, Ushikubi F, Kakizuka A, "et al." |title=Two thromboxane A2 receptor isoforms in human platelets. Opposite coupling to adenylyl cyclase with different sensitivity to Arg60 to Leu mutation. |journal=J. Clin. Invest. |volume=97 |issue= 4 |pages= 949–56 |year= 1996 |pmid= 8613548 |doi=
*cite journal | author=Kinsella BT, O'Mahony DJ, Fitzgerald GA |title=The human thromboxane A2 receptor alpha isoform (TP alpha) functionally couples to the G proteins Gq and G11 in vivo and is activated by the isoprostane 8-epi prostaglandin F2 alpha. |journal=J. Pharmacol. Exp. Ther. |volume=281 |issue= 2 |pages= 957–64 |year= 1997 |pmid= 9152406 |doi=
*cite journal | author=Becker KP, Garnovskaya M, Gettys T, Halushka PV |title=Coupling of thromboxane A2 receptor isoforms to Galpha13: effects on ligand binding and signalling. |journal=Biochim. Biophys. Acta |volume=1450 |issue= 3 |pages= 288–96 |year= 1999 |pmid= 10395940 |doi=
*cite journal | author=Barr CL, Wigg KG, Pakstis AJ, "et al." |title=Genome scan for linkage to Gilles de la Tourette syndrome. |journal=Am. J. Med. Genet. |volume=88 |issue= 4 |pages= 437–45 |year= 1999 |pmid= 10402514 |doi=
*cite journal | author=Zhou H, Yan F, Tai HH |title=Phosphorylation and desensitization of the human thromboxane receptor-alpha by G protein-coupled receptor kinases. |journal=J. Pharmacol. Exp. Ther. |volume=298 |issue= 3 |pages= 1243–51 |year= 2001 |pmid= 11504827 |doi=
*cite journal | author=Vezza R, Mezzasoma AM, Venditti G, Gresele P |title=Prostaglandin endoperoxides and thromboxane A2 activate the same receptor isoforms in human platelets. |journal=Thromb. Haemost. |volume=87 |issue= 1 |pages= 114–21 |year= 2002 |pmid= 11848439 |doi=
*cite journal | author=Turek JW, Halmos T, Sullivan NL, "et al." |title=Mapping of a ligand-binding site for the human thromboxane A2 receptor protein. |journal=J. Biol. Chem. |volume=277 |issue= 19 |pages= 16791–7 |year= 2002 |pmid= 11877412 |doi= 10.1074/jbc.M105872200

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