Coagulation factor II receptor

Coagulation factor II receptor
Coagulation factor II (thrombin) receptor

Rendering of F2R from PDB 1NRN
Symbols F2R; CF2R; HTR; PAR-1; PAR1; TR
External IDs OMIM187930 MGI101802 HomoloGene1510 GeneCards: F2R Gene
RNA expression pattern
PBB GE F2R 203989 x at tn.png
More reference expression data
Species Human Mouse
Entrez 2149 14062
Ensembl ENSG00000181104 ENSMUSG00000048376
UniProt P25116 Q3UK34
RefSeq (mRNA) NM_001992 NM_010169.3
RefSeq (protein) NP_001983 NP_034299.2
Location (UCSC) Chr 5:
76.01 – 76.03 Mb
Chr 13:
96.37 – 96.39 Mb
PubMed search [1] [2]

Proteinase-activated receptor 1 (PAR1) also known as the coagulation factor II (thrombin) receptor is a protein that in humans is encoded by the F2R gene.[1] PAR1 is a G protein-coupled receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor.[2]



Several selective antagonists for the PAR1 receptor have been developed, for use as anti-clotting agents for the treatment of heart disease.

  • SCH-530,348

See also


  1. ^ Bahou WF, Nierman WC, Durkin AS, Potter CL, Demetrick DJ (September 1993). "Chromosomal assignment of the human thrombin receptor gene: localization to region q13 of chromosome 5". Blood 82 (5): 1532–7. PMID 8395910. 
  2. ^ "Entrez Gene: F2R coagulation factor II (thrombin) receptor". 

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Metabolites and
signaling molecules
Class B: Secretin like Class C: Metabotropic
glutamate / pheromone Class F:
Frizzled / Smoothened B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

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