KiSS1-derived peptide receptor

The KiSS1-derived peptide receptor (also known as GPR54) is a G protein-coupled receptorcite journal | author = Lee DK, Nguyen T, O'Neill GP, Cheng R, Liu Y, Howard AD, Coulombe N, Tan CP, Tang-Nguyen AT, George SR, O'Dowd BF | title = Discovery of a receptor related to the galanin receptors | journal = FEBS Lett. | volume = 446 | issue = 1 | pages = 103–7 | year = 1999 | pmid = 10100623 | doi = | issn = ] which binds the peptide hormone kisspeptin.cite journal | author = Ohtaki T, Shintani Y, Honda S, Matsumoto H, Hori A, Kanehashi K, Terao Y, Kumano S, Takatsu Y, Masuda Y, Ishibashi Y, Watanabe T, Asada M, Yamada T, Suenaga M, Kitada C, Usuki S, Kurokawa T, Onda H, Nishimura O, Fujino M | title = Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor | journal = Nature | volume = 411 | issue = 6837 | pages = 613–7 | year = 2001 | pmid = 11385580 | doi = 10.1038/35079135 | issn = ] cite journal | author = Muir AI, Chamberlain L, Elshourbagy NA, Michalovich D, Moore DJ, Calamari A, Szekeres PG, Sarau HM, Chambers JK, Murdock P, Steplewski K, Shabon U, Miller JE, Middleton SE, Darker JG, Larminie CG, Wilson S, Bergsma DJ, Emson P, Faull R, Philpott KL, Harrison DC | title = AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1 | journal = J. Biol. Chem. | volume = 276 | issue = 31 | pages = 28969–75 | year = 2001 | pmid = 11387329 | doi = 10.1074/jbc.M102743200 | issn = ] cite journal | author = Kotani M, Detheux M, Vandenbogaerde A, Communi D, Vanderwinden JM, Le Poul E, Brézillon S, Tyldesley R, Suarez-Huerta N, Vandeput F, Blanpain C, Schiffmann SN, Vassart G, Parmentier M | title = The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54 | journal = J. Biol. Chem. | volume = 276 | issue = 37 | pages = 34631–6 | year = 2001 | pmid = 11457843 | doi = 10.1074/jbc.M104847200 | issn = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a galanin-like G protein-coupled receptor that binds metastin, a peptide encoded by the metastasis suppressor gene KISS1. The tissue distribution of the expressed gene suggests that it is involved in the regulation of endocrine function, and this is supported by the finding that this gene appears to play a role in the onset of puberty.cite web | title = Entrez Gene: KISS1R KISS1 receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84634| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Colledge WH |title=GPR54 and puberty. |journal=Trends Endocrinol. Metab. |volume=15 |issue= 9 |pages= 448–53 |year= 2005 |pmid= 15519892 |doi= 10.1016/j.tem.2004.09.008
*cite journal | author=Kaiser UB, Kuohung W |title=KiSS-1 and GPR54 as new players in gonadotropin regulation and puberty. |journal=Endocrine |volume=26 |issue= 3 |pages= 277–84 |year= 2006 |pmid= 16034182 |doi=
*cite journal | author=Seminara SB |title=Metastin and its G protein-coupled receptor, GPR54: critical pathway modulating GnRH secretion. |journal=Frontiers in neuroendocrinology |volume=26 |issue= 3-4 |pages= 131–8 |year= 2006 |pmid= 16309735 |doi= 10.1016/j.yfrne.2005.10.001
*cite journal | author=Tena-Sempere M |title=GPR54 and kisspeptin in reproduction. |journal=Hum. Reprod. Update |volume=12 |issue= 5 |pages= 631–9 |year= 2006 |pmid= 16731583 |doi= 10.1093/humupd/dml023
*cite journal | author=Cerrato F, Seminara SB |title=Human genetics of GPR54. |journal=Reviews in endocrine & metabolic disorders |volume=8 |issue= 1 |pages= 47–55 |year= 2007 |pmid= 17334928 |doi= 10.1007/s11154-007-9027-3
*cite journal | author=Lee DK, Nguyen T, O'Neill GP, "et al." |title=Discovery of a receptor related to the galanin receptors. |journal=FEBS Lett. |volume=446 |issue= 1 |pages= 103–7 |year= 1999 |pmid= 10100623 |doi=
*cite journal | author=Ohtaki T, Shintani Y, Honda S, "et al." |title=Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. |journal=Nature |volume=411 |issue= 6837 |pages= 613–7 |year= 2001 |pmid= 11385580 |doi= 10.1038/35079135
*cite journal | author=Muir AI, Chamberlain L, Elshourbagy NA, "et al." |title=AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1. |journal=J. Biol. Chem. |volume=276 |issue= 31 |pages= 28969–75 |year= 2001 |pmid= 11387329 |doi= 10.1074/jbc.M102743200
*cite journal | author=Clements MK, McDonald TP, Wang R, "et al." |title=FMRFamide-related neuropeptides are agonists of the orphan G-protein-coupled receptor GPR54. |journal=Biochem. Biophys. Res. Commun. |volume=284 |issue= 5 |pages= 1189–93 |year= 2001 |pmid= 11414709 |doi= 10.1006/bbrc.2001.5098
*cite journal | author=Kotani M, Detheux M, Vandenbogaerde A, "et al." |title=The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. |journal=J. Biol. Chem. |volume=276 |issue= 37 |pages= 34631–6 |year= 2001 |pmid= 11457843 |doi= 10.1074/jbc.M104847200
*cite journal | author=Hori A, Honda S, Asada M, "et al." |title=Metastin suppresses the motility and growth of CHO cells transfected with its receptor. |journal=Biochem. Biophys. Res. Commun. |volume=286 |issue= 5 |pages= 958–63 |year= 2001 |pmid= 11527393 |doi= 10.1006/bbrc.2001.5470
*cite journal | author=Ringel MD, Hardy E, Bernet VJ, "et al." |title=Metastin receptor is overexpressed in papillary thyroid cancer and activates MAP kinase in thyroid cancer cells. |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 5 |pages= 2399 |year= 2002 |pmid= 11994395 |doi=
*cite journal | author=Janneau JL, Maldonado-Estrada J, Tachdjian G, "et al." |title=Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells. |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 11 |pages= 5336–9 |year= 2002 |pmid= 12414911 |doi=
*cite journal | author=Bo-Abbas Y, Acierno JS, Shagoury JK, "et al." |title=Autosomal recessive idiopathic hypogonadotropic hypogonadism: genetic analysis excludes mutations in the gonadotropin-releasing hormone (GnRH) and GnRH receptor genes. |journal=J. Clin. Endocrinol. Metab. |volume=88 |issue= 6 |pages= 2730–7 |year= 2003 |pmid= 12788881 |doi=
*cite journal | author=Ikeguchi M, Hirooka Y, Kaibara N |title=Quantitative reverse transcriptase polymerase chain reaction analysis for KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in hepatocellular carcinoma. |journal=J. Cancer Res. Clin. Oncol. |volume=129 |issue= 9 |pages= 531–5 |year= 2003 |pmid= 12898236 |doi= 10.1007/s00432-003-0469-z
*cite journal | author=de Roux N, Genin E, Carel JC, "et al." |title=Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 19 |pages= 10972–6 |year= 2003 |pmid= 12944565 |doi= 10.1073/pnas.1834399100
*cite journal | author=Seminara SB, Messager S, Chatzidaki EE, "et al." |title=The GPR54 gene as a regulator of puberty. |journal=N. Engl. J. Med. |volume=349 |issue= 17 |pages= 1614–27 |year= 2003 |pmid= 14573733 |doi= 10.1056/NEJMoa035322
*cite journal | author=Ikeguchi M, Yamaguchi K, Kaibara N |title=Clinical significance of the loss of KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in esophageal squamous cell carcinoma. |journal=Clin. Cancer Res. |volume=10 |issue= 4 |pages= 1379–83 |year= 2004 |pmid= 14977840 |doi=
*cite journal | author=Bilban M, Ghaffari-Tabrizi N, Hintermann E, "et al." |title=Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts. |journal=J. Cell. Sci. |volume=117 |issue= Pt 8 |pages= 1319–28 |year= 2004 |pmid= 15020672 |doi= 10.1242/jcs.00971
*cite journal | author=Grimwood J, Gordon LA, Olsen A, "et al." |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399

External links

* [http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1337 IUPHAR GPCR Database - KiSS1-derived peptide receptor]
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