GPR182

GPR182 (or G protein-coupled receptor 182) is a human gene (and associated protein) which is an orphan G-protein coupled receptor.cite journal | author = Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA | title = The G protein-coupled receptor repertoires of human and mouse | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 8 | pages = 4903–8 | year = 2003 | month = April | pmid = 12679517 | pmc = 153653 | doi = 10.1073/pnas.0230374100 | url = | issn = ]

When this gene was first cloned, it was proposed to encode an adrenomedullin receptor.cite journal | author = Hänze J, Dittrich K, Dötsch J, Rascher W | title = Molecular cloning of a novel human receptor gene with homology to the rat adrenomedullin receptor and high expression in heart and immune system | journal = Biochem. Biophys. Res. Commun. | volume = 240 | issue = 1 | pages = 183–8 | year = 1997 | month = November | pmid = 9367907 | doi = 10.1006/bbrc.1997.7631 | url = | issn = ] However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM).cite journal | author = Kennedy SP, Sun D, Oleynek JJ, Hoth CF, Kong J, Hill RJ | title = Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response | journal = Biochem. Biophys. Res. Commun. | volume = 244 | issue = 3 | pages = 832–7 | year = 1998 | month = March | pmid = 9535752 | doi = 10.1006/bbrc.1998.8349 | url = | issn = ]

It was subsequently shown that a different GPCR, CALCRL when complexed with RAMP2 can function as an ADM receptor.cite journal | author = McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM | title = RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor | journal = Nature | volume = 393 | issue = 6683 | pages = 333–9 | year = 1998 | month = May | pmid = 9620797 | doi = 10.1038/30666 | url = | issn = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lah JJ, Frishman WH |title=Adrenomedullin: a vasoactive and natriuretic peptide with therapeutic potential. |journal=Heart disease (Hagerstown, Md.) |volume=2 |issue= 3 |pages= 259–65 |year= 2002 |pmid= 11728267 |doi=
*cite journal | author=Mukoyama M, Sugawara A, Nagae T, "et al." |title=Role of adrenomedullin and its receptor system in renal pathophysiology. |journal=Peptides |volume=22 |issue= 11 |pages= 1925–31 |year= 2002 |pmid= 11754983 |doi=
*cite journal | author=Fowler DE, Wang P |title=The cardiovascular response in sepsis: proposed mechanisms of the beneficial effect of adrenomedullin and its binding protein (review). |journal=Int. J. Mol. Med. |volume=9 |issue= 5 |pages= 443–9 |year= 2002 |pmid= 11956648 |doi=
*cite journal | author=Kato J, Kitamura K, Kangawa K, Eto T |title=Receptors for adrenomedullin in human vascular endothelial cells. |journal=Eur. J. Pharmacol. |volume=289 |issue= 2 |pages= 383–5 |year= 1995 |pmid= 7621913 |doi=
*cite journal | author=Martínez A, Miller MJ, Catt KJ, Cuttitta F |title=Adrenomedullin receptor expression in human lung and in pulmonary tumors. |journal=J. Histochem. Cytochem. |volume=45 |issue= 2 |pages= 159–64 |year= 1997 |pmid= 9016306 |doi=
*cite journal | author=Hänze J, Dittrich K, Dötsch J, Rascher W |title=Molecular cloning of a novel human receptor gene with homology to the rat adrenomedullin receptor and high expression in heart and immune system. |journal=Biochem. Biophys. Res. Commun. |volume=240 |issue= 1 |pages= 183–8 |year= 1997 |pmid= 9367907 |doi= 10.1006/bbrc.1997.7631
*cite journal | author=Martínez A, Elsasser TH, Muro-Cacho C, "et al." |title=Expression of adrenomedullin and its receptor in normal and malignant human skin: a potential pluripotent role in the integument. |journal=Endocrinology |volume=138 |issue= 12 |pages= 5597–604 |year= 1997 |pmid= 9389548 |doi=
*cite journal | author=Kennedy SP, Sun D, Oleynek JJ, "et al." |title=Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response. |journal=Biochem. Biophys. Res. Commun. |volume=244 |issue= 3 |pages= 832–7 |year= 1998 |pmid= 9535752 |doi= 10.1006/bbrc.1998.8349
*cite journal | author=Jiménez N, Calvo A, Martínez A, "et al." |title=Expression of adrenomedullin and proadrenomedullin N-terminal 20 peptide in human and rat prostate. |journal=J. Histochem. Cytochem. |volume=47 |issue= 9 |pages= 1167–78 |year= 1999 |pmid= 10449538 |doi=
*cite journal | author=Kuwasako K, Kitamura K, Ito K, "et al." |title=The seven amino acids of human RAMP2 (86) and RAMP3 (59) are critical for agonist binding to human adrenomedullin receptors. |journal=J. Biol. Chem. |volume=276 |issue= 52 |pages= 49459–65 |year= 2002 |pmid= 11591721 |doi= 10.1074/jbc.M108369200
*cite journal | author=Forneris M, Gottardo L, Albertin G, "et al." |title=Expression and function of adrenomedullin and its receptors in Conn's adenoma cells. |journal=Int. J. Mol. Med. |volume=8 |issue= 6 |pages= 675–9 |year= 2002 |pmid= 11712085 |doi=
*cite journal | author=Hänze J, Groneberg DA, Rose F, "et al." |title=Genomic organization and regulation of a human 7-helix transmembrane receptor which is expressed in pulmonary epithelial cells and induced in hypoxia. |journal=Biochem. Biophys. Res. Commun. |volume=291 |issue= 5 |pages= 1160–5 |year= 2002 |pmid= 11883938 |doi= 10.1006/bbrc.2002.6595
*cite journal | author=Dumont CE, Muff R, Flühmann B, "et al." |title=Paracrine/autocrine function of adrenomedullin in peripheral nerves of rats. |journal=Brain Res. |volume=955 |issue= 1-2 |pages= 64–71 |year= 2003 |pmid= 12419522 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Chosa E, Hamada H, Kitamura K, "et al." |title=Expression of adrenomedullin and its receptor by chondrocyte phenotype cells. |journal=Biochem. Biophys. Res. Commun. |volume=303 |issue= 1 |pages= 379–86 |year= 2003 |pmid= 12646214 |doi=
*cite journal | author=Xu P, Dai AG, Zhou HD, "et al." |title= [Study of the expression and role of adrenomedullin and adrenomedullin receptor in patients with chronic obstructive pulmonary disease] |journal=Zhonghua Jie He He Hu Xi Za Zhi |volume=26 |issue= 12 |pages= 765–8 |year= 2004 |pmid= 14720432 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504

External links

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