Angiotensin II receptor type 2

Angiotensin II receptor type 2

Angiotensin II receptor type 2, also known as AGTR2, is a human gene.cite web | title = Entrez Gene: AGTR2 angiotensin II receptor, type 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=186| accessdate = ]

Angiotensin II is a potent pressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors termed AT1 and AT2. AGTR2 belongs to a family 1 of G protein-coupled receptors. It is an integral membrane protein. It plays a role in the central nervous system and cardiovascular functions that are mediated by the renin-angiotensin system. This receptor mediates programmed cell death (apoptosis). In adults, it is highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. It is highly expressed in fetal kidney and intestine. The human AGTR2 gene is composed of three exons and spans at least 5 kb. Exons 1 and 2 encode for 5' untranslated mRNA sequence and exon 3 harbors the entire uninterrupted open reading frame.cite web | title = Entrez Gene: AGTR2 angiotensin II receptor, type 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=186| accessdate = ]

ee also

* Angiotensin II receptor

References

Further reading

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citations =
*cite journal | author=Regitz-Zagrosek V, Neuss M, Warnecke C, "et al." |title=Subtype 2 and atypical angiotensin receptors in the human heart. |journal=Basic Res. Cardiol. |volume=91 Suppl 2 |issue= |pages= 73–7 |year= 1997 |pmid= 8957548 |doi=
*cite journal | author=Berry C, Touyz R, Dominiczak AF, "et al." |title=Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide. |journal=Am. J. Physiol. Heart Circ. Physiol. |volume=281 |issue= 6 |pages= H2337–65 |year= 2002 |pmid= 11709400 |doi=
*cite journal | author=Takayanagi R, Ohnaka K, Sakai Y, "et al." |title=Molecular cloning, sequence analysis and expression of a cDNA encoding human type-1 angiotensin II receptor. |journal=Biochem. Biophys. Res. Commun. |volume=183 |issue= 2 |pages= 910–6 |year= 1992 |pmid= 1550596 |doi=
*cite journal | author=Hein L, Barsh GS, Pratt RE, "et al." |title=Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice. |journal=Nature |volume=377 |issue= 6551 |pages= 744–7 |year= 1995 |pmid= 7477266 |doi= 10.1038/377744a0
*cite journal | author=Ichiki T, Labosky PA, Shiota C, "et al." |title=Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor. |journal=Nature |volume=377 |issue= 6551 |pages= 748–50 |year= 1995 |pmid= 7477267 |doi= 10.1038/377748a0
*cite journal | author=Lazard D, Briend-Sutren MM, Villageois P, "et al." |title=Molecular characterization and chromosome localization of a human angiotensin II AT2 receptor gene highly expressed in fetal tissues. |journal=Recept. Channels |volume=2 |issue= 4 |pages= 271–80 |year= 1995 |pmid= 7719706 |doi=
*cite journal | author=Martin MM, Elton TS |title=The sequence and genomic organization of the human type 2 angiotensin II receptor. |journal=Biochem. Biophys. Res. Commun. |volume=209 |issue= 2 |pages= 554–62 |year= 1995 |pmid= 7733925 |doi= 10.1006/bbrc.1995.1537
*cite journal | author=Chassagne C, Beatty BG, Meloche S |title=Assignment of the human angiotensin II type 2 receptor gene (AGTR2) to chromosome Xq22-q23 by fluorescence in situ hybridization. |journal=Genomics |volume=25 |issue= 2 |pages= 601–3 |year= 1995 |pmid= 7790004 |doi=
*cite journal | author=Koike G, Horiuchi M, Yamada T, "et al." |title=Human type 2 angiotensin II receptor gene: cloned, mapped to the X chromosome, and its mRNA is expressed in the human lung. |journal=Biochem. Biophys. Res. Commun. |volume=203 |issue= 3 |pages= 1842–50 |year= 1994 |pmid= 7945336 |doi= 10.1006/bbrc.1994.2402
*cite journal | author=Martin MM, Su B, Elton TS |title=Molecular cloning of the human angiotensin II type 2 receptor cDNA. |journal=Biochem. Biophys. Res. Commun. |volume=205 |issue= 1 |pages= 645–51 |year= 1995 |pmid= 7999093 |doi=
*cite journal | author=Tsuzuki S, Ichiki T, Nakakubo H, "et al." |title=Molecular cloning and expression of the gene encoding human angiotensin II type 2 receptor. |journal=Biochem. Biophys. Res. Commun. |volume=200 |issue= 3 |pages= 1449–54 |year= 1994 |pmid= 8185599 |doi= 10.1006/bbrc.1994.1613
*cite journal | author=Servant G, Boulay G, Bossé R, "et al." |title=Photoaffinity labeling of subtype 2 angiotensin receptor of human myometrium. |journal=Mol. Pharmacol. |volume=43 |issue= 5 |pages= 677–83 |year= 1993 |pmid= 8502225 |doi=
*cite journal | author=Yamada T, Horiuchi M, Dzau VJ |title=Angiotensin II type 2 receptor mediates programmed cell death. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 1 |pages= 156–60 |year= 1996 |pmid= 8552595 |doi=
*cite journal | author=Zhang J, Pratt RE |title=The AT2 receptor selectively associates with Gialpha2 and Gialpha3 in the rat fetus. |journal=J. Biol. Chem. |volume=271 |issue= 25 |pages= 15026–33 |year= 1996 |pmid= 8663053 |doi=
*cite journal | author=Katsuya T, Horiuchi M, Minami S, "et al." |title=Genomic organization and polymorphism of human angiotensin II type 2 receptor: no evidence for its gene mutation in two families of human premature ovarian failure syndrome. |journal=Mol. Cell. Endocrinol. |volume=127 |issue= 2 |pages= 221–8 |year= 1997 |pmid= 9099917 |doi=
*cite journal | author=Akishita M, Ito M, Lehtonen JY, "et al." |title=Expression of the AT2 receptor developmentally programs extracellular signal-regulated kinase activity and influences fetal vascular growth. |journal=J. Clin. Invest. |volume=103 |issue= 1 |pages= 63–71 |year= 1999 |pmid= 9884335 |doi=
*cite journal | author=Lehtonen JY, Daviet L, Nahmias C, "et al." |title=Analysis of functional domains of angiotensin II type 2 receptor involved in apoptosis. |journal=Mol. Endocrinol. |volume=13 |issue= 7 |pages= 1051–60 |year= 1999 |pmid= 10406457 |doi=
*cite journal | author=Knowle D, Ahmed S, Pulakat L |title=Identification of an interaction between the angiotensin II receptor sub-type AT2 and the ErbB3 receptor, a member of the epidermal growth factor receptor family. |journal=Regul. Pept. |volume=87 |issue= 1-3 |pages= 73–82 |year= 2000 |pmid= 10710290 |doi=
*cite journal | author=Hansen JL, Servant G, Baranski TJ, "et al." |title=Functional reconstitution of the angiotensin II type 2 receptor and G(i) activation. |journal=Circ. Res. |volume=87 |issue= 9 |pages= 753–9 |year= 2000 |pmid= 11055978 |doi=

G protein-coupled receptors

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