Retinoic acid-inducible orphan G protein-coupled receptor

protein
Name = G protein-coupled receptor, family C, group 5, member A
caption =


width =
HGNCid = 9836
Symbol = GPRC5A
AltSymbols = RAIG1, RAI3
EntrezGene = 9052
OMIM = 604138
RefSeq = NM_003979
UniProt = Q8NFJ5
PDB =
ECnumber =
Chromosome = 12
Arm = p
Band = 13
LocusSupplementaryData = -p12.3protein
Name = G protein coupled receptor, family C, group 5, member B
caption =


width =
HGNCid = 13308
Symbol = GPRC5B
AltSymbols = RAIG2
EntrezGene = 51704
OMIM = 605948
RefSeq = NM_016235
UniProt = Q9NZH0
PDB =
ECnumber =
Chromosome = 16
Arm = p
Band = 12
LocusSupplementaryData = protein
Name = G protein-coupled receptor, family C, group 5, member C
caption =


width =
HGNCid = 13309
Symbol = GPRC5C
AltSymbols = RAIG3
EntrezGene = 55890
OMIM = 605949
RefSeq = NM_022036
UniProt = Q9NQ84
PDB =
ECnumber =
Chromosome = 17
Arm = q
Band = 25
LocusSupplementaryData = protein
Name = G protein-coupled receptor, family C, group 5, member D
caption =


width =
HGNCid = 13310
Symbol = GPRC5D
AltSymbols =
EntrezGene = 55507
OMIM = 607437
RefSeq = NM_018654
UniProt = Q9NZD1
PDB =
ECnumber =
Chromosome = 12
Arm = p
Band = 13.3
LocusSupplementaryData =

The Retinoic Acid-Inducible orphan G-protein-coupled receptors (RAIG) are a group of four closely related G protein-coupled receptors whose expression is induced by retinoic acid.cite journal | author = Cheng Y, Lotan R | title = Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor | journal = J. Biol. Chem. | volume = 273 | issue = 52 | pages = 35008–15 | year = 1998 | pmid = 9857033 | doi = | issn = ] cite journal | author = Bräuner-Osborne H, Krogsgaard-Larsen P | title = Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain | journal = Genomics | volume = 65 | issue = 2 | pages = 121–8 | year = 2000 | pmid = 10783259 | doi = 10.1006/geno.2000.6164 | issn = ] cite journal | author = Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN, Pangalos MN | title = Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C) | journal = Genomics | volume = 67 | issue = 1 | pages = 8–18 | year = 2000 | pmid = 10945465 | doi = 10.1006/geno.2000.6226 | issn = ] cite journal | author = Bräuner-Osborne H, Jensen AA, Sheppard PO, Brodin B, Krogsgaard-Larsen P, O'Hara P | title = Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D | journal = Biochim. Biophys. Acta | volume = 1518 | issue = 3 | pages = 237–48 | year = 2001 | pmid = 11311935 | doi = | issn = ]

The exact function of these proteins has not been determined but they may provide a mechanism by which retinoic acid can influence G protein signal transduction cascades. In addition, RAIG receptors interact with members of the frizzled class of G protein-coupled receptors and appear to activate the Wnt signaling pathway.cite journal | author = Harada Y, Yokota C, Habas R, Slusarski DC, He X | title = Retinoic acid-inducible G protein-coupled receptors bind to frizzled receptors and may activate non-canonical Wnt signaling | journal = Biochem. Biophys. Res. Commun. | volume = 358 | issue = 4 | pages = 968–75 | year = 2007 | pmid = 17521608 | doi = 10.1016/j.bbrc.2007.04.208 | issn = ]

References

External links

* [http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1323 IUPHAR GPCR Database - GPRC5 receptors - RAIG₁, RAIG₂, RAIG₃, RAIG₄]
*MeshName|GPRC5A+protein,+human
*MeshName|GPRC5B+protein,+human
*MeshName|GPRC5C+protein,+human