Neurotensin receptor 1

Neurotensin receptor 1 (high affinity)
Identifiers
Symbols	NTSR1; NTR
External IDs	OMIM: 162651 MGI: 97386 HomoloGene: 68261 IUPHAR: NTS1 GeneCards: NTSR1 Gene
Gene Ontology Molecular function • receptor activity • G-protein coupled receptor activity • neurotensin receptor activity, G-protein coupled Cellular component • endoplasmic reticulum • Golgi apparatus • plasma membrane • plasma membrane • integral to plasma membrane Biological process • G-protein coupled receptor protein signaling pathway • synaptic transmission • adult locomotory behavior Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4923	18216
Ensembl	ENSG00000101188	ENSMUSG00000027568
UniProt	P30989	Q9QZQ2
RefSeq (mRNA)	NM_002531	NM_018766.2
RefSeq (protein)	NP_002522	NP_061236.1
Location (UCSC)	Chr 20: 61.34 – 61.39 Mb	Chr 2: 180.23 – 180.28 Mb
PubMed search	[1]	[2]

Neurotensin receptor type 1 is a protein that in humans is encoded by the NTSR1 gene.^[1][2]

Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion.^[2]

See also

• Neurotensin receptor

References

1. ^ Laurent P, Clerc P, Mattei MG, Forgez P, Dumont X, Ferrara P, Caput D, Rostene W (Oct 1994). "Chromosomal localization of mouse and human neurotensin receptor genes". Mamm Genome 5 (5): 303–6. doi:10.1007/BF00389545. PMID 8075503. 
2. ^ ^{a b} "Entrez Gene: NTSR1 neurotensin receptor 1 (high affinity)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4923. 

External links

• "Neurotensin Receptors: NTS₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3004. 

Further reading

• Vincent JP (1996). "Neurotensin receptors: binding properties, transduction pathways, and structure.". Cell. Mol. Neurobiol. 15 (5): 501–12. doi:10.1007/BF02071313. PMID 8719037. 
• Vincent JP, Mazella J, Kitabgi P (1999). "Neurotensin and neurotensin receptors.". Trends Pharmacol. Sci. 20 (7): 302–9. doi:10.1016/S0165-6147(99)01357-7. PMID 10390649. 
• Vita N, Laurent P, Lefort S, et al. (1993). "Cloning and expression of a complementary DNA encoding a high affinity human neurotensin receptor.". FEBS Lett. 317 (1-2): 139–42. doi:10.1016/0014-5793(93)81509-X. PMID 8381365. 
• Le F, Groshan K, Zeng XP, Richelson E (1997). "Characterization of the genomic structure, promoter region, and a tetranucleotide repeat polymorphism of the human neurotensin receptor gene.". J. Biol. Chem. 272 (2): 1315–22. doi:10.1074/jbc.272.2.1315. PMID 8995438. 
• Boudin H, Pélaprat D, Rostène W, et al. (1998). "Correlative ultrastructural distribution of neurotensin receptor proteins and binding sites in the rat substantia nigra.". J. Neurosci. 18 (20): 8473–84. PMID 9763490. 
• Ye X, Mehlen P, Rabizadeh S, et al. (1999). "TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction.". J. Biol. Chem. 274 (42): 30202–8. doi:10.1074/jbc.274.42.30202. PMID 10514511. 
• Wang L, Friess H, Zhu Z, et al. (2000). "Neurotensin receptor-1 mRNA analysis in normal pancreas and pancreatic disease.". Clin. Cancer Res. 6 (2): 566–71. PMID 10690540. 
• Cusack B, Jansen K, McCormick DJ, et al. (2000). "A single amino acid of the human and rat neurotensin receptors (subtype 1) determining the pharmacological profile of a species-selective neurotensin agonist.". Biochem. Pharmacol. 60 (6): 793–801. doi:10.1016/S0006-2952(00)00409-3. PMID 10930533. 
• Oakley RH, Laporte SA, Holt JA, et al. (2001). "Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*.". J. Biol. Chem. 276 (22): 19452–60. doi:10.1074/jbc.M101450200. PMID 11279203. 
• Leplatois P, Josse A, Guillemot M, et al. (2001). "Neurotensin induces mating in Saccharomyces cerevisiae cells that express human neurotensin receptor type 1 in place of the endogenous pheromone receptor.". Eur. J. Biochem. 268 (18): 4860–7. doi:10.1046/j.0014-2956.2001.02407.x. PMID 11559354. 
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052. 
• Lundquist JT, Büllesbach EE, Golden PL, Dix TA (2002). "Topography of the neurotensin (NT)(8-9) binding site of human NT receptor-1 probed with NT(8-13) analogs.". J. Pept. Res. 59 (2): 55–61. PMID 11906607. 
• Somaï S, Gompel A, Rostène W, Forgez P (2002). "Neurotensin counteracts apoptosis in breast cancer cells.". Biochem. Biophys. Res. Commun. 295 (2): 482–8. doi:10.1016/S0006-291X(02)00703-9. PMID 12150975. 
• Martin S, Navarro V, Vincent JP, Mazella J (2002). "Neurotensin receptor-1 and -3 complex modulates the cellular signaling of neurotensin in the HT29 cell line.". Gastroenterology 123 (4): 1135–43. doi:10.1053/gast.2002.36000. PMID 12360476. 
• Toy-Miou-Leong M, Cortes CL, Beaudet A, et al. (2004). "Receptor trafficking via the perinuclear recycling compartment accompanied by cell division is necessary for permanent neurotensin cell sensitization and leads to chronic mitogen-activated protein kinase activation.". J. Biol. Chem. 279 (13): 12636–46. doi:10.1074/jbc.M303384200. PMID 14699144. 
• Magazin M, Poszepczynska-Guigné E, Bagot M, et al. (2004). "Sezary syndrome cells unlike normal circulating T lymphocytes fail to migrate following engagement of NT1 receptor.". J. Invest. Dermatol. 122 (1): 111–8. doi:10.1046/j.0022-202X.2003.22131.x. PMID 14962098. 
• Brun P, Mastrotto C, Beggiao E, et al. (2005). "Neuropeptide neurotensin stimulates intestinal wound healing following chronic intestinal inflammation.". Am. J. Physiol. Gastrointest. Liver Physiol. 288 (4): G621–9. doi:10.1152/ajpgi.00140.2004. PMID 15764810. 

Metabolites and
signaling molecules

Eicosanoid	CysLT (1, 2) · LTB4 (1, 2) · FPRL1 · OXE · Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) · Prostacyclin · Thromboxane
Other	Bile acid · Cannabinoid (CB1, CB2, GPR (18, 55, 119)) · EBI2 · Estrogen · Free fatty acid (1, 2, 3, 4) · Lactate  · Lysophosphatidic acid (1, 2, 3, 4, 5, 6)  · Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) · Niacin (1, 2) · Oxoglutarate · PAF · Sphingosine-1-phosphate (1, 2, 3, 4, 5) · Succinate

Peptide

Neuropeptide	B/W (1, 2) · FF (1, 2) · S · Y (1, 2, 4, 5) · Neuromedin (B, U (1, 2)) · Neurotensin (1, 2)
Other	Anaphylatoxin (C3a, C5a) · Angiotensin (1, 2) · Apelin · Bombesin (BRS3, GRPR, NMBR) · Bradykinin (B1, B2) · Chemokine · Cholecystokinin (A, B) · Endothelin (A, B) · Formyl peptide (1, 2, 3) · FSH · Galanin (1, 2, 3) · GHB receptor · Gonadotropin-releasing hormone (1, 2) · Ghrelin · Kisspeptin · Luteinizing hormone/choriogonadotropin · MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) · Melanocortin (1, 2, 3, 4, 5) · MCHR (1, 2) · Motilin · Opioid (Delta, Kappa, Mu, Nociceptin & Zeta, but not Sigma) · Orexin (1, 2) · Oxytocin · Prokineticin (1, 2) · Prolactin-releasing peptide · Relaxin (1, 2, 3, 4) · Somatostatin (1, 2, 3, 4, 5) · Tachykinin (1, 2, 3) · Thyrotropin · Thyrotropin-releasing hormone · Urotensin-II · Vasopressin (1A, 1B, 2)

Miscellaneous

Orphan	GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Other	Adrenomedullin · Olfactory · Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) · Protease-activated (1, 2, 3, 4) · SREB (1, 2, 3)

Class B: Secretin like

Orphan	GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Other	Brain-specific angiogenesis inhibitor (1, 2, 3) · Cadherin (1, 2, 3) · Calcitonin · CALCRL · CD97 · Corticotropin-releasing hormone (1, 2) · EMR (1, 2, 3) · Glucagon (GR, GIPR, GLP1R, GLP2R) · Growth hormone releasing hormone · PACAPR1 · GPR · Latrophilin (1, 2, 3, ELTD1) · Methuselah-like proteins · Parathyroid hormone (1, 2) · Secretin · Vasoactive intestinal peptide (1, 2)

Class C: Metabotropic
glutamate / pheromone

Taste	TAS1R (1, 2, 3) · TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Other	Calcium-sensing receptor · GABA B (1, 2) · Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) · GPRC6A · GPR (156, 158, 179) · RAIG (1, 2, 3, 4)

Class F:
Frizzled / Smoothened

Frizzled	Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Smoothened	Smoothened

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)