Neuropeptide B/W receptor

protein
Name = neuropeptides B/W receptor 1
caption =


width =
HGNCid = 4522
Symbol = NPBWR1
AltSymbols = GPR7
EntrezGene = 2831
OMIM = 600730
RefSeq = NM_005285
UniProt = P48145
PDB =
ECnumber =
Chromosome = 8
Arm = p22
Band = -q21.13
LocusSupplementaryData = protein
Name = neuropeptides B/W receptor 2
caption =


width =
HGNCid = 4530
Symbol = NPBWR2
AltSymbols = GPR8
EntrezGene = 2832
OMIM = 600731
RefSeq = NM_005286
UniProt = P48146
PDB =
ECnumber =
Chromosome = 20
Arm = q
Band = 13.3
LocusSupplementaryData =

The neuropeptide B/W receptors are members of the G-protein coupled receptor superfamily of integral membrane proteins which bind the neuropeptides B and W.cite journal | author = Tanaka H, Yoshida T, Miyamoto N, Motoike T, Kurosu H, Shibata K, Yamanaka A, Williams SC, Richardson JA, Tsujino N, Garry MG, Lerner MR, King DS, O'Dowd BF, Sakurai T, Yanagisawa M | title = Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 10 | pages = 6251–6 | year = 2003 | pmid = 12719537 | doi = 10.1073/pnas.0837789100 | issn = ] These receptors are predominately expressed in the CNS and have a number of functions including regulation of the secretion of cortisol.cite journal | author = Mazzocchi G, Rebuffat P, Ziolkowska A, Rossi GP, Malendowicz LK, Nussdorfer GG | title = G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades | journal = J. Clin. Endocrinol. Metab. | volume = 90 | issue = 6 | pages = 3466–71 | year = 2005 | pmid = 15797961 | doi = 10.1210/jc.2004-2132 | issn = ] cite journal | author = Singh G, Davenport AP | title = Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system | journal = Br. J. Pharmacol. | volume = 148 | issue = 8 | pages = 1033–41 | year = 2006 | pmid = 16847439 | doi = 10.1038/sj.bjp.0706825 | issn = ]

References

External links

* [http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1341 IUPHAR GPCR Database - Neuropeptide W/neuropeptide B receptors]
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