[cite journal | author = Beuschlein F, Fassnacht M, Klink A, Allolio B, Reincke M | title = ACTH-receptor expression, regulation and role in adrenocortial tumor formation | journal = Eur. J. Endocrinol. | volume = 144 | issue = 3 | pages = 199–206 | year = 2001 | pmid = 11248736 | doi = 10.1530/eje.0.1440199 | issn = ] ]It is found in the zona fasciculata of the adrenal cortex and stimulates production of cortisol. (By contrast, aldosterone production from the zona glomerulosa is stimulated primarily by angiotensin II.)
ee also
* Melanocortin receptor
References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Cone RD, Mountjoy KG, Robbins LS, "et al." |title=Cloning and functional characterization of a family of receptors for the melanotropic peptides. |journal=Ann. N. Y. Acad. Sci. |volume=680 |issue= |pages= 342–63 |year= 1993 |pmid= 8390157 |doi=
*cite journal | author=Allolio B, Reincke M |title=Adrenocorticotropin receptor and adrenal disorders. |journal=Horm. Res. |volume=47 |issue= 4-6 |pages= 273–8 |year= 1997 |pmid= 9167964 |doi=
*cite journal | author=Tatro JB |title=Receptor biology of the melanocortins, a family of neuroimmunomodulatory peptides. |journal=Neuroimmunomodulation |volume=3 |issue= 5 |pages= 259–84 |year= 1997 |pmid= 9218248 |doi=
*cite journal | author=Mountjoy KG, Robbins LS, Mortrud MT, Cone RD |title=The cloning of a family of genes that encode the melanocortin receptors. |journal=Science |volume=257 |issue= 5074 |pages= 1248–51 |year= 1992 |pmid= 1325670 |doi=
*cite journal | author=Clark AJ, McLoughlin L, Grossman A |title=Familial glucocorticoid deficiency associated with point mutation in the adrenocorticotropin receptor. |journal=Lancet |volume=341 |issue= 8843 |pages= 461–2 |year= 1993 |pmid= 8094489 |doi=
*cite journal | author=Tsigos C, Arai K, Hung W, Chrousos GP |title=Hereditary isolated glucocorticoid deficiency is associated with abnormalities of the adrenocorticotropin receptor gene. |journal=J. Clin. Invest. |volume=92 |issue= 5 |pages= 2458–61 |year= 1993 |pmid= 8227361 |doi=
*cite journal | author=Gantz I, Tashiro T, Barcroft C, "et al." |title=Localization of the genes encoding the melanocortin-2 (adrenocorticotropic hormone) and melanocortin-3 receptors to chromosomes 18p11.2 and 20q13.2-q13.3 by fluorescence in situ hybridization. |journal=Genomics |volume=18 |issue= 1 |pages= 166–7 |year= 1994 |pmid= 8276410 |doi= 10.1006/geno.1993.1448
*cite journal | author=Gantz I, Konda Y, Tashiro T, "et al." |title=Molecular cloning of a novel melanocortin receptor. |journal=J. Biol. Chem. |volume=268 |issue= 11 |pages= 8246–50 |year= 1993 |pmid= 8463333 |doi=
*cite journal | author=Naville D, Barjhoux L, Jaillard C, "et al." |title=Demonstration by transfection studies that mutations in the adrenocorticotropin receptor gene are one cause of the hereditary syndrome of glucocorticoid deficiency. |journal=J. Clin. Endocrinol. Metab. |volume=81 |issue= 4 |pages= 1442–8 |year= 1996 |pmid= 8636348 |doi=
*cite journal | author=Naville D, Jaillard C, Barjhoux L, "et al." |title=Genomic structure and promoter characterization of the human ACTH receptor gene. |journal=Biochem. Biophys. Res. Commun. |volume=230 |issue= 1 |pages= 7–12 |year= 1997 |pmid= 9020063 |doi= 10.1006/bbrc.1996.5911
*cite journal | author=Yang YK, Ollmann MM, Wilson BD, "et al." |title=Effects of recombinant agouti-signaling protein on melanocortin action. |journal=Mol. Endocrinol. |volume=11 |issue= 3 |pages= 274–80 |year= 1997 |pmid= 9058374 |doi=
*cite journal | author=Naville D, Barjhoux L, Jaillard C, "et al." |title=Stable expression of normal and mutant human ACTH receptor: study of ACTH binding and coupling to adenylate cyclase. |journal=Mol. Cell. Endocrinol. |volume=129 |issue= 1 |pages= 83–90 |year= 1997 |pmid= 9175632 |doi=
*cite journal | author=Penhoat A, Naville D, Jaillard C, "et al." |title=Presence of multiple functional polyadenylation signals in the 3'-untranslated region of human corticotropin receptor cDNA. |journal=Biochim. Biophys. Acta |volume=1356 |issue= 3 |pages= 249–52 |year= 1997 |pmid= 9194567 |doi=
*cite journal | author=Ishii T, Ogata T, Sasaki G, "et al." |title=Novel mutations of the ACTH receptor gene in a female adult patient with adrenal unresponsiveness to ACTH. |journal=Clin. Endocrinol. (Oxf) |volume=53 |issue= 3 |pages= 389–92 |year= 2000 |pmid= 10971458 |doi=
*cite journal | author=Flück CE, Martens JW, Conte FA, Miller WL |title=Clinical, genetic, and functional characterization of adrenocorticotropin receptor mutations using a novel receptor assay. |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 9 |pages= 4318–23 |year= 2002 |pmid= 12213892 |doi=
*cite journal | author=Swords FM, Baig A, Malchoff DM, "et al." |title=Impaired desensitization of a mutant adrenocorticotropin receptor associated with apparent constitutive activity. |journal=Mol. Endocrinol. |volume=16 |issue= 12 |pages= 2746–53 |year= 2003 |pmid= 12456795 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
ee also
* melanocortinRoy et al. 2007 Differential regulation of the human ACTH receptor (MC2R) by human MRAP isoforms alpha and beta in isogenic HEK 293 cells. Mol Endocrinol 21:1656-1669
External links
* [http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2350 IUPHAR GPCR Database - Melanocortin MC2 receptor]
*
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