GABBR1

Gamma-aminobutyric acid (GABA) B receptor, 1, also known as GABBR1, is a human gene.

PBB_Summary
section_title =
summary_text = Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates 4 transcript variants.cite web | title = Entrez Gene: GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2550| accessdate = ]

ee also

* GABAB receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Fraser DD, Mudrick-Donnon LA, MacVicar BA |title=Astrocytic GABA receptors. |journal=Glia |volume=11 |issue= 2 |pages= 83–93 |year= 1994 |pmid= 7927650 |doi= 10.1002/glia.440110203
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Kaupmann K, Huggel K, Heid J, "et al." |title=Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors. |journal=Nature |volume=386 |issue= 6622 |pages= 239–46 |year= 1997 |pmid= 9069281 |doi= 10.1038/386239a0
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Grifa A, Totaro A, Rommens JM, "et al." |title=GABA (gamma-amino-butyric acid) neurotransmission: identification and fine mapping of the human GABAB receptor gene. |journal=Biochem. Biophys. Res. Commun. |volume=250 |issue= 2 |pages= 240–5 |year= 1998 |pmid= 9753614 |doi= 10.1006/bbrc.1998.9296
*cite journal | author=Goei VL, Choi J, Ahn J, "et al." |title=Human gamma-aminobutyric acid B receptor gene: complementary DNA cloning, expression, chromosomal location, and genomic organization. |journal=Biol. Psychiatry |volume=44 |issue= 8 |pages= 659–66 |year= 1999 |pmid= 9798068 |doi=
*cite journal | author=Kaupmann K, Schuler V, Mosbacher J, "et al." |title=Human gamma-aminobutyric acid type B receptors are differentially expressed and regulate inwardly rectifying K+ channels. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 25 |pages= 14991–6 |year= 1999 |pmid= 9844003 |doi=
*cite journal | author=White JH, Wise A, Main MJ, "et al." |title=Heterodimerization is required for the formation of a functional GABA(B) receptor. |journal=Nature |volume=396 |issue= 6712 |pages= 679–82 |year= 1999 |pmid= 9872316 |doi= 10.1038/25354
*cite journal | author=Kuner R, Köhr G, Grünewald S, "et al." |title=Role of heteromer formation in GABAB receptor function. |journal=Science |volume=283 |issue= 5398 |pages= 74–7 |year= 1999 |pmid= 9872744 |doi=
*cite journal | author=Makoff A |title=Molecular cloning of human GABABR1 and its tissue distribution. |journal=Brain Res. Mol. Brain Res. |volume=64 |issue= 1 |pages= 137–40 |year= 1999 |pmid= 9889352 |doi=
*cite journal | author=Peters HC, Kämmer G, Volz A, "et al." |title=Mapping, genomic structure, and polymorphisms of the human GABABR1 receptor gene: evaluation of its involvement in idiopathic generalized epilepsy. |journal=Neurogenetics |volume=2 |issue= 1 |pages= 47–54 |year= 2000 |pmid= 9933300 |doi=
*cite journal | author=Ng GY, Clark J, Coulombe N, "et al." |title=Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activity. |journal=J. Biol. Chem. |volume=274 |issue= 12 |pages= 7607–10 |year= 1999 |pmid= 10075644 |doi=
*cite journal | author=Sander T, Peters C, Kämmer G, "et al." |title=Association analysis of exonic variants of the gene encoding the GABAB receptor and idiopathic generalized epilepsy. |journal=Am. J. Med. Genet. |volume=88 |issue= 4 |pages= 305–10 |year= 1999 |pmid= 10402495 |doi=
*cite journal | author=Wise A, Green A, Main MJ, "et al." |title=Calcium sensing properties of the GABA(B) receptor. |journal=Neuropharmacology |volume=38 |issue= 11 |pages= 1647–56 |year= 1999 |pmid= 10587080 |doi=
*cite journal | author=Sullivan R, Chateauneuf A, Coulombe N, "et al." |title=Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor. |journal=J. Pharmacol. Exp. Ther. |volume=293 |issue= 2 |pages= 460–7 |year= 2000 |pmid= 10773016 |doi=
*cite journal | author=Schwarz DA, Barry G, Eliasof SD, "et al." |title=Characterization of gamma-aminobutyric acid receptor GABAB(1e), a GABAB(1) splice variant encoding a truncated receptor. |journal=J. Biol. Chem. |volume=275 |issue= 41 |pages= 32174–81 |year= 2000 |pmid= 10906333 |doi= 10.1074/jbc.M005333200
*cite journal | author=White JH, McIllhinney RA, Wise A, "et al." |title=The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 25 |pages= 13967–72 |year= 2001 |pmid= 11087824 |doi= 10.1073/pnas.240452197
*cite journal | author=Couve A, Kittler JT, Uren JM, "et al." |title=Association of GABA(B) receptors and members of the 14-3-3 family of signaling proteins. |journal=Mol. Cell. Neurosci. |volume=17 |issue= 2 |pages= 317–28 |year= 2001 |pmid= 11178869 |doi= 10.1006/mcne.2000.0938
*cite journal | author=Muñoz A, Arellano JI, DeFelipe J |title=GABABR1 receptor protein expression in human mesial temporal cortex: changes in temporal lobe epilepsy. |journal=J. Comp. Neurol. |volume=449 |issue= 2 |pages= 166–79 |year= 2002 |pmid= 12115687 |doi= 10.1002/cne.10287

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes