Calcitonin receptor

The calcitonin receptor is a G protein-coupled receptor which binds the peptide hormone calcitonin and is involved in maintenance of calcium homeostasis.cite journal | author = Purdue BW, Tilakaratne N, Sexton PM | title = Molecular pharmacology of the calcitonin receptor | journal = Recept. Channels | volume = 8 | issue = 3-4 | pages = 243–55 | year = 2002 | pmid = 12529940 | doi = | issn = ]

It works by activating the G-proteins G_s and G_q [ [http://senselab.med.yale.edu/NeuronDB/receptors2.asp#Neuropeptide%20Y%20receptors, senselab] ]

References

Further reading

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citations =
*cite journal | author=Pondel M |title=Calcitonin and calcitonin receptors: bone and beyond. |journal=International journal of experimental pathology |volume=81 |issue= 6 |pages= 405–22 |year= 2001 |pmid= 11298188 |doi=
*cite journal | author=Gorn AH, Lin HY, Yamin M, "et al." |title=Cloning, characterization, and expression of a human calcitonin receptor from an ovarian carcinoma cell line. |journal=J. Clin. Invest. |volume=90 |issue= 5 |pages= 1726–35 |year= 1992 |pmid= 1331173 |doi=
*cite journal | author=Albrandt K, Brady EM, Moore CX, "et al." |title=Molecular cloning and functional expression of a third isoform of the human calcitonin receptor and partial characterization of the calcitonin receptor gene. |journal=Endocrinology |volume=136 |issue= 12 |pages= 5377–84 |year= 1995 |pmid= 7588285 |doi=
*cite journal | author=Egerton M, Needham M, Evans S, "et al." |title=Identification of multiple human calcitonin receptor isoforms: heterologous expression and pharmacological characterization. |journal=J. Mol. Endocrinol. |volume=14 |issue= 2 |pages= 179–89 |year= 1995 |pmid= 7619207 |doi=
*cite journal | author=Nussenzveig DR, Mathew S, Gershengorn MC |title=Alternative splicing of a 48-nucleotide exon generates two isoforms of the human calcitonin receptor. |journal=Endocrinology |volume=136 |issue= 5 |pages= 2047–51 |year= 1995 |pmid= 7720653 |doi=
*cite journal | author=Nakamura M, Hashimoto T, Nakajima T, "et al." |title=A new type of human calcitonin receptor isoform generated by alternative splicing. |journal=Biochem. Biophys. Res. Commun. |volume=209 |issue= 2 |pages= 744–51 |year= 1995 |pmid= 7733946 |doi=
*cite journal | author=Pérez Jurado LA, Li X, Francke U |title=The human calcitonin receptor gene (CALCR) at 7q21.3 is outside the deletion associated with the Williams syndrome. |journal=Cytogenet. Cell Genet. |volume=70 |issue= 3-4 |pages= 246–9 |year= 1995 |pmid= 7789182 |doi=
*cite journal | author=Nussenzveig DR, Thaw CN, Gershengorn MC |title=Inhibition of inositol phosphate second messenger formation by intracellular loop one of a human calcitonin receptor. Expression and mutational analysis of synthetic receptor genes. |journal=J. Biol. Chem. |volume=269 |issue= 45 |pages= 28123–9 |year= 1994 |pmid= 7961748 |doi=
*cite journal | author=Kuestner RE, Elrod RD, Grant FJ, "et al." |title=Cloning and characterization of an abundant subtype of the human calcitonin receptor. |journal=Mol. Pharmacol. |volume=46 |issue= 2 |pages= 246–55 |year= 1994 |pmid= 8078488 |doi=
*cite journal | author=Frendo JL, Pichaud F, Mourroux RD, "et al." |title=An isoform of the human calcitonin receptor is expressed in TT cells and in medullary carcinoma of the thyroid. |journal=FEBS Lett. |volume=342 |issue= 2 |pages= 214–6 |year= 1994 |pmid= 8143880 |doi=
*cite journal | author=Masi L, Becherini L, Gennari L, "et al." |title=Allelic variants of human calcitonin receptor: distribution and association with bone mass in postmenopausal Italian women. |journal=Biochem. Biophys. Res. Commun. |volume=245 |issue= 2 |pages= 622–6 |year= 1998 |pmid= 9571205 |doi= 10.1006/bbrc.1998.8445
*cite journal | author=Taboulet J, Frenkian M, Frendo JL, "et al." |title=Calcitonin receptor polymorphism is associated with a decreased fracture risk in post-menopausal women. |journal=Hum. Mol. Genet. |volume=7 |issue= 13 |pages= 2129–33 |year= 1999 |pmid= 9817931 |doi=
*cite journal | author=Christopoulos G, Perry KJ, Morfis M, "et al." |title=Multiple amylin receptors arise from receptor activity-modifying protein interaction with the calcitonin receptor gene product. |journal=Mol. Pharmacol. |volume=56 |issue= 1 |pages= 235–42 |year= 1999 |pmid= 10385705 |doi=
*cite journal | author=Nishikawa T, Ishikawa H, Yamamoto S, Koshihara Y |title=A novel calcitonin receptor gene in human osteoclasts from normal bone marrow. |journal=FEBS Lett. |volume=458 |issue= 3 |pages= 409–14 |year= 2000 |pmid= 10570950 |doi=
*cite journal | author=Beaudreuil J, Taboulet J, Orcel P, "et al." |title=Calcitonin receptor mRNA in mononuclear leucocytes from postmenopausal women: decrease during osteoporosis and link to bone markers with specific isoform involvement. |journal=Bone |volume=27 |issue= 1 |pages= 161–8 |year= 2000 |pmid= 10865224 |doi=
*cite journal | author=Wada S, Yasuda S, Nagai T, "et al." |title=Regulation of calcitonin receptor by glucocorticoid in human osteoclast-like cells prepared in vitro using receptor activator of nuclear factor-kappaB ligand and macrophage colony-stimulating factor. |journal=Endocrinology |volume=142 |issue= 4 |pages= 1471–8 |year= 2001 |pmid= 11250927 |doi=
*cite journal | author=Ogden CA, deCathelineau A, Hoffmann PR, "et al." |title=C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells. |journal=J. Exp. Med. |volume=194 |issue= 6 |pages= 781–95 |year= 2001 |pmid= 11560994 |doi=
*cite journal | author=Nosaka Y, Tachi Y, Shimpuku H, "et al." |title=Association of calcitonin receptor gene polymorphism with early marginal bone loss around endosseous implants. |journal=The International journal of oral & maxillofacial implants |volume=17 |issue= 1 |pages= 38–43 |year= 2002 |pmid= 11858573 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899

External links

* [http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1358 IUPHAR GPCR Database - Calcitonin receptor family]
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